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Product Name: L-Proline
Chemical Formula: C5H9NO2
CAS Number: 147-85-3
EC Number: 205-702-2
Synonyms: (S)-Pyrrolidine-2-carboxylic acid, Proline
Recommended Use: Laboratory reagent, pharmaceutical applications, food additive, academic and research settings
Supplier: List current company and local distributor information, contact numbers for emergencies
Emergency Telephone: Refer to local and national emergency numbers
Classification: Not classified as hazardous under GHS criteria
Signal Word: No signal word required
Hazard Statements: Product does not present significant acute toxicity or health hazards in normal conditions of use
Precautionary Statements: Avoid prolonged or repeated exposure, prevent dust generation, adopt suitable workplace hygiene
Other Hazards: Dust can cause mechanical irritation to eyes, nose, or throat, and may aggravate existing respiratory conditions
Pictograms: No hazard pictograms mandated
NFPA Ratings: Health: 1, Flammability: 0, Instability: 0
Chemical Name: L-Proline
Concentration: Greater than 99% pure
CAS Number: 147-85-3
Impurities and Additives: Trace impurities related to manufacturing routes, typically less than 1%
Molecular Weight: 115.13 g/mol
Inhalation: Move affected person to fresh air, keep at rest, seek medical advice if symptoms persist
Skin Contact: Remove contaminated clothing, wash with plenty of water, seek medical attention if irritation develops
Eye Contact: Flush eyes thoroughly with water, remove contact lenses, continue to rinse for several minutes, consult medical professional if irritation or discomfort remains
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical help if discomfort occurs
Most Important Symptoms/Effects: Dust may cause respiratory or eye irritation; large amounts can upset the stomach
Medical Attention and Special Treatment: Treat symptoms as they appear, no specific antidote known
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical powder, or carbon dioxide
Unsuitable Media: Avoid high-volume water jet which may spread powder
Special Hazards: Combustion releases carbon oxides, nitrogen oxides, toxic fumes possible
Protective Equipment: Firefighters should wear suitable self-contained breathing apparatus, full protective gear
Advice for Firefighters: Approach fire from upwind side, prevent run-off from entering drains or watercourses, avoid inhaling combustion gases
Personal Precautions: Prevent dust formation, avoid inhaling dust, use personal protective equipment such as gloves and goggles
Environmental Precautions: Prevent entry into sewers, soil, or watercourses, minimize spillage
Methods for Cleanup: Sweep up with minimal dust generation, place in clean compatible container for controlled disposal, ventilate area, wash spill site after product pick-up
Other Information: Use non-sparking tools, decontaminate risk areas appropriately, alert environmental authorities if large quantities enter waterways
Handling Precautions: Avoid creating dust, work in well-ventilated areas, restrict food and drink from handling locations, employ routine hygiene practices such as washing hands
Protection Measures: Wear gloves, goggles, lab coat
Storage Conditions: Store under dry, temperature-controlled conditions, protected from moisture and incompatible substances such as strong oxidizers
Container Requirements: Use tightly closed, clearly labelled containers
Incompatibilities: Strong acids, strong bases, oxidizing agents
Safe Storage Advice: Store at room temperature, secure from unauthorized access
Engineering Controls: Use local exhaust ventilation or process enclosures to keep airborne levels below recommended limits
Exposure Limits: No occupational exposure limits established specifically for L-Proline; use workplace practices that minimize exposure
Personal Protective Equipment (PPE): Gloves (nitrile or latex), safety goggles or glasses with side shields, lab coat, dust mask or respirator in case of dusty conditions
Hygiene Measures: Avoid eating, drinking, or smoking during use, wash hands before breaks and after handling
Environmental Controls: Do not allow material to contaminate water systems, use containment where practical
Appearance: White to off-white crystalline powder
Odor: Essentially odorless
pH: Approximately 5.5-7.0 (1% aqueous solution)
Melting Point: 221 °C (decomposes above this temperature)
Boiling Point: Not applicable, decomposes before boiling
Solubility: Freely soluble in water, slightly soluble in ethanol
Vapor Pressure: Negligible at room temperature
Density: 1.35 g/cm³
Partition Coefficient (n-octanol/water): -2.54 (log Pow)
Flash Point: Not flammable under normal conditions
Auto-Ignition Temperature: No data available
Evaporation Rate: Not established, non-volatile
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Not expected to react violently under normal conditions
Hazardous Reactions: Contact with strong oxidizers may cause hazardous reactions
Conditions to Avoid: Moisture, heat, sources of ignition
Materials to Avoid: Strong acids, strong bases, oxidizing agents
Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides, irritating fumes
Acute Toxicity: Oral LD50 (rat): >5,000 mg/kg, indicating low acute toxicity
Skin Corrosion/Irritation: Not a skin irritant in animal studies
Serious Eye Damage/Irritation: May cause mild, transient mechanical irritation due to dust
Respiratory Effects: Inhalation of dust may cause irritation of lungs or airways
Sensitization: Not known to cause allergic skin or respiratory reactions
Chronic Effects: No evidence of long-term health effects in humans at reasonable levels of exposure
Carcinogenicity: Not considered carcinogenic by IARC, NTP, ACGIH, or OSHA
Mutagenicity: No evidence of genotoxicity
Reproductive Toxicity: No harm reported in animal or human data
Ecotoxicity: No significant toxicity to aquatic or terrestrial life at typical environmental concentrations
Persistence and Degradability: Readily biodegradable through natural materials breakdown
Bioaccumulation: Low potential, does not concentrate in living organisms
Mobility in Soil: High; dissolves readily in water and disperses
Other Adverse Effects: Negligible impact when used responsibly, significant releases may affect local water chemistry due to increased nitrogen load
Waste Treatment Methods: Dispose according to local, regional, and national regulations, preferably as non-hazardous organic waste
Disposal of Packaging: Triple rinse and recycle or dispose of containers safely, do not reuse empty packaging for other materials
Special Precautions: Prevent contamination of water bodies and soil through managed disposal
Incineration: Material may be incinerated in properly equipped facilities
Other Information: Consult local environmental authorities about best practices in area
UN Number: Not regulated as a dangerous good for transport under ADR, IMDG, IATA
Proper Shipping Name: L-Proline
Transport Hazard Class: Not classified as hazardous
Packing Group: Not assigned
Special Precautions: Ensure packaging prevents dust release, store away from foodstuffs and animal feed during transit
Environmental Hazards: No direct environmental hazard linked to transport
Transport in Bulk: Follow local transport guidelines, use sealed containers
TSCA Inventory: Listed
DSL/NDSL (Canada): Listed
REACH (EU): Exempt as naturally occurring amino acid, not subject to authorization or restriction
OSHA Status: Not classified as hazardous substance or mixture
WHMIS (Canada): Not a controlled product
Environmental Regulations: Product poses minimal risk if handled, used, and disposed of properly
Other Local/National Regulations: Check compliance with food, pharmaceutical, or academic regulations where applicable
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
