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MSDS for L-Phenylalanine

Identification

Product Name: L-Phenylalanine
Chemical Formula: C9H11NO2
CAS Number: 63-91-2
Synonyms: 2-Amino-3-phenylpropanoic acid
Recommended Use: Used in food additives, pharmaceuticals, nutritional supplements, laboratory research
Supplier Details: Manufacturer’s address, emergency phone number, and contact information provided with each shipment, traceable for audits and workplace safety requirements

Hazard Identification

Potential Health Effects: Dust inhalation can irritate respiratory tract, possible mild skin or eye irritation, ingestion in large quantities may affect susceptible individuals
Hazard Class: Not classified as hazardous under GHS guidelines
Signal Word: None required under normal handling
Pictograms: Not applicable
Precautionary Statements: Avoid breathing dust, wear suitable gloves, prevent contact with eyes
Emergency Overview: White crystalline solid, no significant odor, non-flammable, stable under recommended storage conditions

Composition / Information on Ingredients

Chemical Identity: L-Phenylalanine
Concentration: Greater than 99% purity
Impurities: Trace byproducts below exposure thresholds, controlled in manufacturing process
Molecular Weight: 165.19 g/mol

First Aid Measures

Inhalation: Move person to fresh air, monitor for any persistent cough or throat discomfort, seek medical advice if symptoms develop
Skin Contact: Remove contaminated clothing, flush affected area with plenty of water, wash gently with soap and water, medical attention only if irritation occurs
Eye Contact: Rinse immediately with clean water for at least 15 minutes, hold eyelids open, seek medical advice if irritation persists
Ingestion: Rinse mouth with water, seek medical attention if a large amount is swallowed or adverse symptoms appear, avoid induction of vomiting unless instructed by medical personnel

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, foam, carbon dioxide, or dry chemical extinguishers can manage small fires
Hazards from Combustion: Produces carbon monoxide, carbon dioxide, nitrogen oxides under fire conditions
Special Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective gear to avoid inhalation of products of combustion
Precautions: Avoid entering confined fire spaces without proper equipment, water runoff may require containment to reduce environmental impact

Accidental Release Measures

Personal Precautions: Wear appropriate respiratory protection if dusty, avoid contact with skin and eyes, utilize suitable work gloves
Environmental Precautions: Prevent spillage from entering drains, soil, or water sources, use absorbent material for cleanup
Clean-up Methods: Collect spilled material using shovel or broom, transfer to labeled container, moisten to suppress dusting, ventilate affected area after clean-up

Handling and Storage

Handling: Handle with local exhaust or dust extraction in place, avoid generating airborne dust, use non-sparking tools, prohibit eating, drinking, and smoking in work area, practice regular hand washing
Storage Conditions: Store in dry, tightly sealed containers away from sources of intense heat and incompatible materials like strong acids or oxidizers, temperature-controlled rooms below 25°C or 77°F offer optimal stability
Incompatibles: Strong oxidizers and acids may trigger hazardous reactions, verify chemical storage guidelines before co-locating

Exposure Controls and Personal Protection

Occupational Exposure Limit: No established limits under OSHA, ACGIH or NIOSH, but nuisance dust limits may apply
Ventilation: Use local exhaust to limit airborne concentrations, supplement with general room ventilation
Respiratory Protection: If dusty conditions arise, wear approved particulate respirators
Skin Protection: Use chemical-resistant gloves such as nitrile or neoprene, change gloves regularly based on exposure
Eye Protection: Safety goggles recommended where risk of dust contact exists
Other Protective Equipment: Lab coats or aprons minimize contact with personal clothing

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Virtually odorless
Solubility: Moderately soluble in water (24.5 g/L at 25°C), sparingly soluble in alcohol
Melting Point: 270°C (decomposes)
Boiling Point: Decomposes before boiling
pH (5% solution): 5.4-6.0
Vapor Pressure: Negligible
Specific Gravity: 1.293 g/cm³
Particle Size: Varies in commercial lots, typically 100-200 mesh for supplements and food additives

Stability and Reactivity

Chemical Stability: Stable under normal temperature and recommended storage conditions
Reactivity: Avoid contact with strong acids, bases, and oxidizing agents
Hazardous Reactions: Material is not self-reactive or polymerizable under normal handling
Decomposition Products: Thermal decomposition can create carbon oxides, ammonia, nitrogen oxides

Toxicological Information

Acute Toxicity: Oral LD50 (rat): >5000 mg/kg, considered low toxicity, no significant risk reported at recommended dietary levels
Skin Contact: Can cause mild transient irritation in sensitive individuals with prolonged contact
Eye Contact: May cause minor irritation, avoid rubbing eyes after exposure
Chronic Effects: Long-term occupational exposure data are limited, consuming high doses without medical oversight could raise risk of metabolic disorder in individuals with phenylketonuria (PKU)
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, or OSHA
Mutagenicity: No evidence found in standard testing

Ecological Information

Aquatic Toxicity: Low toxicity to aquatic organisms, degrades slowly in water, significant build-ups unlikely with normal use
Mobility: Limited mobility in soil due to weak solubility; unlikely to impact groundwater at normal usage rates
Persistence and Degradability: Biodegradable, breaks down under influence of soil microorganisms
Bioaccumulation: Not expected to accumulate in fish or wildlife, considered environmentally benign in small releases

Disposal Considerations

Waste Treatment Methods: Dispose of surplus or contaminated material through licensed waste disposal contractor, do not discharge to municipal sewers, surface water or soil
Container Disposal: Rinse thoroughly, remove or deface labels, recycle or dispose according to local regulations
Precautions: Handle clean-up residues with same care as original product, maintain documentation of disposal for compliance

Transport Information

UN Number: Not classified as hazardous for shipping
Transport Hazard Classes: Not regulated under ADR, IMDG, IATA or US DOT
Packing Group: Not applicable
Special Transport Precautions: Protect from moisture and physical damage, ensure containers are properly sealed, keep away from incompatible chemicals during shipment

Regulatory Information

TSCA Status: Listed on the US Toxic Substances Control Act Inventory
DSL/NDSL Status (Canada): Included on the Canadian Domestic Substances List
EU REACH Registration: Exempt as an ingredient in food and pharma uses, substance generally not subject to restrictions
Other Regulations: No SARA Title III hazards, not listed under CERCLA, not controlled under state right-to-know laws
Labeling Requirements: No hazard required under GHS, but workplace labels should summarize handling guidance and first aid to maintain informed safety practices