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Product Name: L-Leucine
Chemical Formula: C6H13NO2
CAS Number: 61-90-5
Synonyms: 2-Amino-4-methylpentanoic acid
Product Use: Nutritional supplement, laboratory reagent, food additive, research applications
Supplier Details: Manufacturer and distributor information available on request by regulatory authorities or institutional safety personnel
Emergency Contact: Accessible via ChemWatch or Poison Control Center
Classification: Not classified as hazardous according to OSHA, GHS, or WHMIS standards
Physical Hazards: Dust can cause irritation in eyes, nose, and throat; combustible in fine particulate
Health Hazards: Potential mild irritation to skin and eyes, possible throat discomfort upon inhalation; rare allergic response
Environmental Hazards: No significant environmental hazard under normal conditions of use and disposal
Signal Word: None required by current global regulations
Hazard Symbols: Not applicable due to low acute toxicity
Chemical Name: L-Leucine
Concentration: Greater than 98% pure
Impurities: Handling batches below food or pharma grade can yield trace organic residues or salts
EINECS Number: 200-522-0
Additional Components: Product typically does not contain preservatives, excipients, or additives unless specified by supplier
Eye Contact: Rinse eyes immediately with plenty of water, lifting eyelids as necessary; seek medical attention if irritation persists
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing and launder before reuse
Inhalation: Move person into fresh air; administer artificial respiration if necessary; call a medical professional if symptoms continue
Ingestion: Rinse mouth with water; do not induce vomiting unless directed by medical personnel; seek medical attention if feeling unwell
Symptoms: Irritation, coughing, mild discomfort, rarely allergic rash
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide
Specific Hazards: Fine dust can form combustible mixtures with air; risk of dust explosion in enclosed spaces
Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective gear
Firefighting Instructions: Avoid inhaling smoke, fumes, and particulate matter generated by combustion; contain runoff to prevent environmental contamination
Byproducts: Thermal decomposition may generate carbon oxides, nitrogen oxides, or other hazardous vapors in an uncontrolled blaze
Personal Precautions: Evacuate area of unnecessary personnel; limit dust formation; ventilate area well
Protective Equipment: Use gloves, dust masks, goggles, and lab coats or protective suits
Spill Cleanup Methods: Sweep or shovel material into dry containers for disposal; use non-sparking tools; wash spill area with water after collection
Environmental Precautions: Prevent large quantities from entering waterways or drains
Waste Disposal: Dispose in accordance with local, regional, or national regulations; avoid dispersal of dust in the air during cleanup
Precautions for Safe Handling: Avoid generating airborne dust; always use appropriate PPE when transferring material; avoid eating, drinking, or smoking nearby
Storage Conditions: Store in a cool, dry, well-ventilated area away from sources of ignition; keep container tightly closed
Incompatible Materials: Store apart from strong oxidizers, acids, and bases; avoid contact with strong reducing agents
Shelf Life: Store under recommended conditions to maintain quality for 2–3 years
Special Storage Notes: Protect from moisture, heat, and direct sunlight; use original containers whenever practical
Exposure Limits: Not specified by OSHA, NIOSH, ACGIH for L-Leucine; minimize dust exposure to lowest practical level
Engineering Controls: Adequate local exhaust ventilation, especially while mixing, weighing, or transferring powder
Personal Protective Equipment (PPE): Safety goggles, gloves, lab coat, and NIOSH-certified particulate mask or dust respirator
Hygiene Measures: Wash hands thoroughly after use; remove and clean contaminated clothing before reuse
Monitoring: Consider regular air sampling in environments with frequent, large-scale handling of similar powders
Appearance: White crystalline powder
Odor: Odorless or faintly characteristic
pH: 5.5–7.0 (1% solution in water)
Melting Point: 293°C (decomposes before melting)
Boiling Point: Not applicable (decomposes)
Solubility: Slightly soluble in water, practically insoluble in ether and alcohol
Specific Gravity: Around 1.293
Vapor Pressure: Negligible
Partition Coefficient (log Kow): -1.96
Flash Point: Not applicable
Explosion Limits: Not determined, dust may present risk in confined air
Chemical Stability: Stable under standard temperatures and pressures
Conditions to Avoid: Excessive heat, humidity, open flames, electrostatic discharges
Incompatible Materials: Powerful oxidizing or reducing agents, strong acids or bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, and other hazardous fumes possible if burned
Polymerization: Will not occur under normal handling conditions
Acute Toxicity: Low, with no significant health effects identified in small doses; LD50 oral (rat) > 5000 mg/kg
Chronic Toxicity: No known long-term toxicity; not listed as carcinogen, mutagen, or reproductive toxin by NTP, IARC, or OSHA
Routes of Exposure: Ingestion, inhalation, skin, and eyes
Symptoms: Irritation to mucous membranes, mild skin redness, possible respiratory discomfort
Sensitization: Rare reports of allergic responses in susceptible individuals
Specific Target Organ Toxicity: Not identified
Medical Conditions Aggravated by Exposure: Pre-existing respiratory or skin conditions may become irritated by dust
Environmental Fate: Biodegradable in soil and water; does not persist or bioaccumulate
Toxicity to Aquatic Life: No significant toxicity to fish or aquatic invertebrates at relevant concentrations
Toxicity to Plants: Not harmful under typical use and accidental release scenarios
Mobility in Soil: High solubility promotes rapid dilution and breakdown
Other Effects: L-Leucine forms part of the natural nitrogen cycle and is rapidly utilized by micro-organisms
Regulatory Statements: No classification regarding environmental hazard under REACH or GHS
Waste Disposal Methods: Dispose of in accordance with institutional, local, regional, and national regulations; landfill or incinerate as non-hazardous waste
Container Disposal: Rinse empty packaging; recycle or dispose as per regulations governing chemical waste
Precautions: Avoid generating dust during disposal; use protective equipment
Unused Material: Donate to academic/research programs if uncontaminated and permitted or send to licensed chemical disposal facility
UN Number: Not regulated
Proper Shipping Name: L-Leucine
Hazard Class: None assigned
Packing Group: None required
Labeling Requirements: No hazardous labels; general chemical labeling recommended
Special Transport Precautions: Prevent container breakage and exposure to moisture in transit; ship in sealed packaging
Regulatory Status: Not subject to international transport regulations for dangerous goods (IATA, IMDG, ADR)
Inventory Listings: Included in TSCA, EINECS, DSL, ENCS, AICS
OSHA Status: Product not regulated as hazardous under OSHA's Hazard Communication Standard
SARA/Title III: Product contains no Section 302, 304, or 313 reportable ingredients
California Proposition 65: Contains no chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm
REACH/CLP: Substance meets exemption criteria for registration under Annex IV/V for low hazard
Other Regulations: No food, drug, or cosmetic use restrictions when handled by GMP-compliant processes
Workplace Safety: Adhere to institutional chemical hygiene plans and ensure employee training for safe powder handling
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
