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Material Safety Data Sheet: L-Histidine

Identification

Product Name: L-Histidine
Synonyms: 2-Amino-3-(1H-imidazol-4-yl)propanoic acid
CAS Number: 71-00-1
EC Number: 200-745-3
Recommended Use: Amino acid supplement, pharmaceutical applications, research and biochemical studies
Manufacturer: Supplier contact and emergency number available on request through distribution channels
Molecular Formula: C6H9N3O2
Molecular Weight: 155.16 g/mol

Hazard Identification

Hazard Classification: Not classified as hazardous according to GHS standards
Signal Word: None required
Hazard Statements: May cause mild skin or eye irritation on contact with large quantities
Precautionary Statements: Wash hands after handling, avoid dust generation, store in original package
Potential Health Effects: Short exposure can result in mild discomfort in some people, ingestion considered low risk
Environmental Hazards: Not considered hazardous for the environment in small quantities

Composition / Information on Ingredients

Chemical Name: L-Histidine
Concentration: 98-100% pure
Impurities: Trace inorganic salts or heavy metals < 0.1%
Formula: C6H9N3O2
Type: Single component substance

First Aid Measures

Inhalation: Move person to fresh air, seek medical advice if symptoms continue
Skin Contact: Wash skin thoroughly with soap and water, remove contaminated clothing
Eye Contact: Rinse under gentle running water for at least 15 minutes, consult physician if irritation occurs
Ingestion: Rinse mouth, drink water, do not induce vomiting, seek attention if unwell
Most Important Symptoms: Irritation of skin or eye, possible mild respiratory effect for sensitive individuals

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Specific Hazards: Decomposition products may include nitrogen oxides, carbon oxides
Protective Equipment: Firefighters should wear self-contained breathing apparatus, chemical-resistant clothing
Unusual Fire Risks: Fine dust can form explosive mixtures with air in rare cases where dispersion is high
Advice for Firefighters: Move product away from fire if safe to do so, use standard fire control techniques

Accidental Release Measures

Personal Precautions: Wear gloves, dust mask or respirator, safety goggles
Environmental Precautions: Prevent large-scale entry into drains or water systems
Cleanup Methods: Sweep up material carefully to avoid dust generation, place in labeled container for disposal
Handling Spills: Avoid inhaling, ventilate area, wash surfaces after collection of product

Handling and Storage

Safe Handling: Use in well-ventilated area, minimize dust, avoid contact with eyes and skin
Storage Requirements: Store tightly closed in a cool, dry, well-ventilated area, separate from strong oxidizers and acids
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Special Precautions: Keep container tightly closed when not in use, label storage areas appropriately, monitor for container breakage

Exposure Controls and Personal Protection

Occupational Exposure Limits: No specific exposure limits established by OSHA or ACGIH
Engineering Controls: Use local exhaust for dusty environments, maintain general area ventilation
Personal Protective Equipment: Safety glasses, gloves, lab coat
Respiratory Protection: Use dust mask or N95 particulate respirator as needed
Hygiene Measures: Wash hands after handling, avoid eating or drinking while handling the powder

Physical and Chemical Properties

Appearance: White crystalline powder
Odor: Odorless
pH (1% solution): 7.0 - 8.5
Melting Point: Decomposes above 287 °C
Boiling Point: Not applicable (decomposes)
Solubility: Soluble in water, practically insoluble in ethanol
Bulk Density: Approximately 0.4-0.6 g/cm³
Vapor Pressure: Not applicable
Partition Coefficient (log Kow): -3.32
Flash Point: Not relevant (non-flammable in solid form)

Stability and Reactivity

Chemical Stability: Stable under recommended storage and use conditions
Possibility of Hazardous Reactions: No polymerization or hazardous reaction expected
Conditions to Avoid: High heat, moisture, avoid creating very fine dust
Incompatible Materials: Strong oxidizers and acids
Decomposition Products: Nitrogen oxides, carbon oxides at high temperatures

Toxicological Information

Acute Toxicity: Low toxicity via oral and dermal routes (LD50 oral rat >5000 mg/kg)
Skin Corrosion/Irritation: Not expected to irritate at low exposure, irritation possible if prolonged or in sensitive individuals
Serious Eye Damage/Irritation: May cause temporary irritation if dust contacts eye
Respiratory Sensitization: Dust inhalation may cause mild respiratory discomfort
Carcinogenicity: No evidence of carcinogenicity in humans or animals
Reproductive Toxicity: No adverse reproductive effects in studies
Long-Term Effects: Long use in nutrition and medicine without adverse health trends

Ecological Information

Ecotoxicity: Low potential for harm to aquatic or terrestrial organisms
Persistence and Degradability: Readily biodegradable in the environment
Bioaccumulative Potential: Does not bioaccumulate (low log Kow)
Mobility in Soil: High mobility expected in aqueous environments
Other Adverse Effects: Not known to disrupt natural systems, break down rapidly in wastewater and soil

Disposal Considerations

Safe Disposal: Dispose of in accordance with local and national regulations
Disposal Method: Incinerate in a chemical incinerator, landfill in properly designated site
Packaging Disposal: Triple-rinse empty containers, recycle or dispose of as appropriate
Special Instructions: Avoid disposal to surface water or sewer in bulk quantities

Transport Information

UN Number: Not regulated for transport
Shipping Name: L-Histidine
Transport Hazard Class: Not classified as dangerous
Packing Group: Not applicable
Marine Pollutant: No
Transport Labeling: Ordinary packaging, no specific UN markings
Special Precautions: Secure packaging to prevent damage, keep dry during transport

Regulatory Information

TSCA Status: Listed
REACH Status: Registered or exempted
SARA Title III: No reportable quantities
OSHA Classification: Non-hazardous
California Proposition 65: Not listed
WHMIS Classification (Canada): Not controlled
EU GHS: Not hazardous
Other National Inventories: Listed in Australia, Japan, Korea, China chemical inventories