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Material Safety Data Sheet for L-Glutamine

Identification

Product name: L-Glutamine
Chemical formula: C5H10N2O3
Synonyms: 2-Amino-4-carbamoylbutanoic acid
CAS number: 56-85-9
Recommended use: Nutritional supplement, cell culture ingredient, laboratory reagent
Manufacturer details: Provided by supplier
Emergency contact: Refer to local health and safety authorities

Hazard Identification

Classification: Not classified as hazardous under GHS standards
Physical hazards: No fire or explosion risk under normal conditions
Health hazards: Limited irritant potential for skin, eyes, and respiratory system
Environmental hazards: Not expected to cause adverse effects under standard use
Signal word: None required
Pictograms: None required
Other hazards: Dust may irritate nose or throat during handling

Composition / Information on Ingredients

Chemical name: L-Glutamine
PURITY: >98%
CAS number: 56-85-9
EC number: 200-292-1
Molecular weight: 146.14 g/mol
Impurities: Trace, generally below regulatory concern
Stabilizing additives: None

First Aid Measures

Inhalation: Move individual to fresh air; seek medical advice if symptoms develop
Skin contact: Wash skin well with soap and water; remove contaminated clothing
Eye contact: Rinse eyes with water for ten minutes or longer; obtain medical attention if irritation persists
Ingestion: Rinse mouth; give water; seek help if feeling unwell
Most important symptoms: Mild irritation possible; no serious acute hazards known
Advice for emergency responders: Use personal protective equipment suitable for situation

Fire-Fighting Measures

Suitable extinguishing media: Water spray, carbon dioxide, dry chemical, foam
Unsuitable media: Direct water jet for large fires
Hazards from combustion: May generate oxides of carbon and nitrogen under fire
Protective equipment: Use self-contained breathing apparatus
Other considerations: Keep containers cool; avoid breathing dust or fumes

Accidental Release Measures

Personal precautions: Wear gloves, goggles, dust mask
Spill response: Sweep or vacuum up material; avoid creating dust
Ventilation: Ensure good airflow in area
Environmental precautions: Prevent entry into waterways and drains
Cleanup methods: Collect in appropriate container for disposal; wash area with water
Other notes: Follow local procedures and report significant releases

Handling and Storage

Handling precautions: Always avoid inhaling dust, contact with eyes or skin
Hygiene measures: Wash hands after handling; avoid eating, drinking, or smoking in work area
Storage requirements: Store at room temperature, in tightly sealed container; keep dry
Incompatible materials: Keep away from strong acids, strong bases, and oxidizers
Other recommendations: Use with local exhaust and minimize dust formation

Exposure Controls and Personal Protection

Exposure limits: No occupational exposure limits established
Engineering controls: Use adequate ventilation
Respiratory protection: Use dust mask or respirator if dust forms
Eye protection: Use chemical safety goggles
Skin protection: Wear suitable gloves (nitrile or latex) and lab coat
Environmental controls: Avoid dispersal to environment
Other protection: Emergency eyewash facility should be accessible

Physical and Chemical Properties

Appearance: White crystalline powder
Odor: Odorless
Melting point: 185–187°C (decomposes)
Solubility: Soluble in water
pH (solution): About 4.5–6.0 (5% in water)
Boiling point: Not applicable
Flash point: Not applicable
Vapor pressure: Negligible
Density: approx. 1.46 g/cm³
Partition coefficient: Not available
Viscosity: Not applicable
Decomposition temperature: Above 185°C
Explosive properties: No risk under normal conditions
Oxidizing properties: Not an oxidizer

Stability and Reactivity

Chemical stability: Stable under usual handling and storage conditions
Reactivity: No dangerous reactivity noted
Conditions to avoid: Excessive moisture, heat, strong oxidizers
Incompatible substances: Acids, bases, oxidizing agents
Hazardous decomposition: May release CO, CO2, nitrogen oxides upon heating
Polymerization: Will not occur

Toxicological Information

Acute toxicity: Oral LD50 (rat) >8,000 mg/kg, showing low toxicity
Inhalation risk: Low under normal conditions; keep dust levels minimized
Skin/eye irritation: Slight, temporary irritation possible
Sensitization: No evidence
Chronic effects: Not known to cause chronic health issues
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Teratogenicity: No teratogenic or mutagenic data indicating risk
Other information: No reports of reproductive toxicity or organ damage

Ecological Information

Ecotoxicity: No adverse effects expected on aquatic organisms at normal concentrations
Persistence and degradability: Readily biodegradable in environment
Bioaccumulation: Unlikely (low log Kow, high water solubility)
Mobility in soil: High mobility due to water solubility
Other adverse effects: Not expected to disrupt biological wastewater treatment

Disposal Considerations

Waste disposal method: Treat as non-hazardous; dispose according to local regulations
RCRA status: Not a hazardous waste under 40 CFR 261
Container disposal: Rinse, recycle, or dispose per local norms
Special precautions: Prevent material from entering drains or waterways

Transport Information

UN number: Not regulated
UN proper shipping name: Not regulated
Transport hazard class: No restriction
Packing group: Not assigned
Special precautions: Protect containers from physical damage and moisture
Other data: No transport-related hazards or labeling requirements

Regulatory Information

US TSCA: Listed
EU REACH: Pre-registered
Canada DSL: Listed
OSHA hazard class: Not regulated
WHMIS classification: Not controlled
Other regulations: No specific labeling required under major international chemical safety laws
Additional notes: Not subject to restrictions for import, export, or use as food additive in many jurisdictions