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Material Safety Data Sheet (MSDS): L-Cysteine Hydrochloride Monohydrate

Identification

Product Name: L-Cysteine Hydrochloride Monohydrate
Synonyms: L-Cysteine HCl, L-Cysteine Hydrochloride, Monohydrate Form
Chemical Formula: C3H7NO2S·HCl·H2O
CAS Number: 7048-04-6
EC Number: 200-157-7
Recommended Use: Laboratory chemicals, food additive, pharmaceutical applications
Supplier Identification: Include company name, address, emergency contact number, and email for rapid response.

Hazard Identification

GHS Classification: Irritant to eyes and skin, potential respiratory sensitizer if inhaled as powder
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, may cause mild skin irritation, may cause respiratory irritation
Pictograms: Exclamation mark (acute toxicity, irritant)
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, use only in a well-ventilated environment, wear protective equipment
Potential Health Effects: Inhalation triggers cough and throat discomfort, contact with eyes leads to redness and pain, skin contact produces mild irritation in sensitive individuals, ingestion results in mild gastrointestinal symptoms such as nausea or stomachache
Environmental Impact: Not classified as hazardous for the environment under current GHS guidelines

Composition / Information on Ingredients

Chemical Name: L-Cysteine Hydrochloride Monohydrate
Common Name: L-Cysteine HCl Monohydrate
Content: >98% purity
Impurities: Chloride salts, minimal trace inorganic impurities
Molecular Weight: 175.64 g/mol
Relevant Identifiers: No additional hazardous ingredients reported

First Aid Measures

Inhalation: Remove to fresh air, provide support for breathing if symptoms persist, consult a healthcare professional for further assessment
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water and mild soap, seek attention if irritation or redness does not resolve
Eye Contact: Rinse cautiously with clean, lukewarm water for several minutes while holding eyelids apart, remove contact lenses if present and easy to do, seek further medical assistance if irritation continues
Ingestion: Rinse mouth with clean water, do not induce vomiting, supply water if individual is conscious, seek medical attention for prolonged symptoms
General Advice: Show this safety data sheet to the treating physician, ensure responders are aware of potential exposure and proper PPE use

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, foam, dry chemical or carbon dioxide for small-scale fires involving this material
Specific Hazards: Thermal decomposition releases toxic gases including hydrogen chloride, sulfur oxides, nitrogen oxides, and carbon monoxide
Protective Equipment: Firefighters require full protective clothing including self-contained breathing apparatus
Fire Fighting Precautions: Avoid inhaling fumes, cool storage containers with water spray in case of nearby fire, contain runoff to prevent environmental contamination, remove materials from danger zone if safe to do
Explosion Data: Material is not considered an explosion hazard

Accidental Release Measures

Personal Protective Equipment: Wear appropriate respiratory protection, gloves, goggles, and protective clothing
Spill Response: Avoid generation of airborne dust, ventilate affected area, sweep or shovel spilled material into suitable containers, clean surfaces completely with water after collection
Environmental Precautions: Do not release large quantities into drains or surface water systems; notify authorities if significant contamination occurs
Methods for Clean-Up: Contain and collect solid material for disposal, cool and moisten dust to reduce airborne particles, ensure waste removal complies with local disposal regulations

Handling and Storage

Handling Precautions: Avoid inhaling dust or contact with skin and eyes, handle under local exhaust ventilation, refrain from eating, drinking, or smoking where material is processed
Safe Storage Conditions: Store in tightly closed containers in a cool, dry, and well-ventilated area, avoid high humidity and direct sunlight, segregate from strong oxidizing agents and sources of ignition
Incompatibilities: Reactive with strong oxidizers, halogenating agents, and bases; keep separated to avoid hazardous reactions
Additional Measures: Label all containers clearly and keep them tightly sealed when not in use, ensure emergency washing stations are nearby

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established regulatory exposure limits, minimize exposure based on general dust standards
Engineering Controls: Use exhaust ventilation or process enclosures to limit airborne concentrations
Personal Protective Equipment: Safety goggles or face shield, chemical-resistant gloves (nitrile or rubber), laboratory coat or protective suit, particulate respirator in case of dust formation
Hygiene Measures: Wash hands thoroughly after handling, change contaminated clothing immediately, avoid direct contact with skin or eyes

Physical and Chemical Properties

Appearance: White crystalline powder
Odor: Slightly sulfurous
pH: 1.5–2.5 in 2% water solution
Melting Point: 210–225°C (decomposition)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Highly soluble in water, practically insoluble in ethanol
Vapor Pressure: Negligible under standard conditions
Density: Approximately 1.3 g/cm³
Molecular Weight: 175.64 g/mol
Partition Coefficient: Not determined

Stability and Reactivity

Chemical Stability: Stable under recommended handling and storage, moisture accelerates degradation
Conditions to Avoid: Heat, open flames, exposure to strong oxidizing substances, prolonged contact with air
Incompatible Materials: Strong oxidizers, halogens, strong bases, reactive metals
Hazardous Decomposition Products: Hydrogen chloride, sulfur oxides, nitrogen oxides, carbon dioxide upon thermal breakdown
Polymerization: Not known to occur under normal use and storage

Toxicological Information

Acute Toxicity: Oral LD50 (rat): >5000 mg/kg, not expected to cause acute toxicity through ingestion
Skin Contact: Mildly irritating in studies on rabbits, low hazard potential
Eye Contact: Moderate irritant, causes pain and redness
Chronic Toxicity: Limited chronic toxicity data, not listed as carcinogenic, mutagenic, or teratogenic according to current sources
Inhalation: May cause irritation of the respiratory tract for exposed laboratory workers
Target Organs: Eyes, skin, respiratory system
Sensitization: No confirmed data on skin or respiratory sensitization
After Repeated Exposure: Not expected to cause cumulative organ damage at laboratory handling levels

Ecological Information

Environmental Fate: Expected to undergo slow biodegradation in soil and water, breakdown accelerated with appropriate microbial activity or industrial wastewater systems
Ecotoxicity: Marine and freshwater data limited, expected to be of low toxicity to aquatic organisms at standard usage levels
Bioaccumulation: Not expected to bioaccumulate due to hydrophilic nature
Mobility in Soil: High, given solubility in water, may leach into groundwater under large scale release
PBT/vPvB Assessment: Not considered persistent, bioaccumulative, or toxic

Disposal Considerations

Waste Generation: Collect solid or aqueous residues and place in properly labeled containers
Disposal Methods: Dispose as non-hazardous laboratory waste unless contaminated, use high-temperature incineration or secure landfill for larger amounts, adhere to local and national regulations
Contaminated Packaging: Triple rinse containers and puncture before proper disposal, follow regulations for chemical residue packaging
Preventative Practices: Reduce spills and releases through careful metering and management of working stocks

Transport Information

UN Number: Not classified as hazardous for transport by land, sea, or air under current ADR, IMDG, IATA guidelines
Proper Shipping Name: L-Cysteine Hydrochloride Monohydrate
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Labeling Requirements: No special hazard labels required, general chemical shipment labeling sufficient
Precautions: Secure tightly capped containers to prevent leaks or spills during transport, avoid stacking heavy loads to protect packaging integrity

Regulatory Information

International Inventory Status: Listed on TSCA (US), EINECS (EU), DSL (Canada), ENCS (Japan), AICS (Australia), and other major chemical regulatory inventories
Regulatory Classifications: Not subject to specific restrictions or reporting requirements under REACH, OSHA, SARA, CERCLA, or California Proposition 65
Workplace Classification: Not classified as hazardous substance or dangerous goods, basic chemical hygiene suffices
Label Elements: GHS-compliant product labeling, safety data sheet availability
Other Requirements: Conformity with workplace right-to-know laws and communication standards, training provided for staff working with chemical products, emergency procedures in place for handling spills and exposures