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Product Name: Iodothyronine
Chemical Formula: C15H11I4NO4
Common Synonyms: Thyroid hormone, Triiodothyronine (T3), Thyroxine (T4)
CAS Number: 51-48-9 (T3), 6893-02-3 (T4)
Recommended Uses: Pharmaceutical applications, biochemical research, endocrinological studies
Manufacturer/Supplier: Medical and research chemical providers
Contact Information: Emergency phone number and address details are available from supplier documentation
Emergency Overview: Solid organic compound containing multiple iodine atoms, typically appears as a fine crystalline powder with no significant smell
Hazard Classification: Acute toxicity (oral, inhalation), skin and eye irritant
Signal Word: Warning
Hazard Statements: Harmful if swallowed or inhaled; causes moderate skin and eye irritation; possible effects on thyroid function following prolonged exposure
Pictograms: Exclamation mark for acute health effects
Precautionary Statements: Avoid contact with skin, eyes, and clothing; use only in well-ventilated area; do not eat, drink, or smoke during handling
Chemical Name: 3,5,3',5'-Tetraiodo-L-thyronine or its analogs
Percent by Weight: Over 97% pure (research and pharmaceutical grades)
Impurities: Trace amounts of related iodinated aromatic compounds may be present in technical or lab-grade preparations
Additives: No stabilizers or preservatives in standard raw samples
Hazardous Components: Elemental iodine, aromatic amines (in trace amounts), none above exposure limits
Inhalation: Move affected person to fresh air; keep at rest in a position comfortable for breathing; seek medical advice if symptoms develop such as coughing or throat irritation
Skin Contact: Rinse skin immediately with plenty of water for at least 15 minutes; remove contaminated clothing; seek attention if redness or irritation persists
Eye Contact: Flush eyes with water carefully for several minutes; ensure eyelids are open and remove contact lenses if present; seek medical help if irritation continues
Ingestion: Do not induce vomiting; rinse mouth thoroughly with water; seek medical assistance, show safety sheet if possible
Most Important Symptoms and Effects: Irritation of mucous membranes, potential thyroid hormone effects (palpitations, restlessness), hypersensitivity reactions in rare cases
Suitable Extinguishing Media: Use dry chemical, carbon dioxide, or water spray to control fire in area; foam may be used for larger fires
Specific Hazards Arising from the Substance: Emits toxic fumes of iodine, hydrogen iodide, nitrogen oxides, and carbon oxides when burned
Protective Equipment: Firefighters should wear protective gear including self-contained breathing apparatus and chemical-resistant suit
Special Procedures: Keep upwind of fire; do not allow runoff from firefighting to enter drains or watercourses
Fire/Explosion Risk: Iodothyronine is not flammable under standard conditions but heated decomposition can intensify existing fires due to toxic fume release
Personal Precautions: Wear proper personal protective equipment including gloves, goggles, and laboratory coat; ventilate area
Environmental Precautions: Prevent further spillage or leak; avoid discharge into drains, water systems, or soil
Methods for Clean Up: Sweep up using tools that minimize dust formation and transfer to a sealed appropriate chemical waste container; wash spill site thoroughly after material collection
Other Precautions: Be alert to any potential contamination of equipment and surfaces; dispose of all used materials under regulatory guidelines
Precautions for Safe Handling: Handle in a chemical fume hood or well-ventilated area; minimize dust and inhalation; avoid all unnecessary exposure; use hygienic practices including hand washing after handling
Conditions for Safe Storage: Store locked up in a cool, dry, and well-ventilated location away from incompatible substances such as strong oxidizers, acids, and alkalis; keep containers tightly closed and clearly labeled
Incompatibilities: Avoid contact with strong bases, strong acids, and reducing agents; store in the original container or suitable chemical-resistant jar
Storage Class: Hazardous chemical, non-flammable solid
Engineering Controls: Use local exhaust ventilation, process enclosures, or other engineering controls to keep airborne levels below recommended exposure limits
Respiratory Protection: Use a NIOSH-certified respirator when dust or chemical vapors are expected above threshold levels
Hand Protection: Wear chemical-resistant gloves such as nitrile, neoprene, or latex
Eye Protection: Use safety glasses or goggles designed for chemical splash protection
Skin Protection: Use a laboratory coat, closed shoes, and long sleeves; emergency showers should be accessible
Hygiene Measures: Practice strict hygiene including routine handwashing before breaks and after use; ensure contaminated clothing is removed and washed before reuse
Exposure Limits: No specific OSHA or ACGIH exposure limits established; handle as potentially hazardous respiratory irritant
Appearance: White to off-white crystalline powder, odorless
Molecular Weight: 777.87 g/mol (T4), 650.97 g/mol (T3)
Melting Point: 235°C to 240°C (decomposes)
Solubility: Slightly soluble in water, soluble in ethanol, methanol, and alkaline solutions
Boiling Point: Decomposes before boiling
pH: Slightly acidic to neutral (4.5-7.0, in solution)
Partition Coefficient (Log Kow): 2.5 to 3.1 (estimated)
Vapor Pressure: Negligible at room temperature
Flash Point: Not applicable for solids
Auto-ignition Temperature: Not established
Evaporation Rate: Not relevant for non-volatile solids
Chemical Stability: Stable under recommended handling and storage conditions
Thermal Decomposition: Decomposes with heat to release iodine and nitrogenous gases
Reactivity: Reacts with strong reducing agents and acids, may form hazardous by-products
Incompatible Materials: Contact with concentrated acids, alkalis, and strong oxidants leads to rapid decomposition
Hazardous Polymerization: Will not occur under normal laboratory conditions
Other Information: Prolonged exposure to light and air may cause slow degradation
Acute Toxicity: Oral LD50 (rat): 425 mg/kg (T4); signs of toxicity in animals include increased heart rate, weight loss, nervousness
Routes of Exposure: Inhalation, skin, eye, and ingestion
Symptoms of Overexposure: Palpitations, anxiety, insomnia, hyperactivity, rapid weight loss, skin or eye irritation
Chronic Effects: Altered thyroid function, hormone imbalance, possible cardiovascular issues including arrhythmias in cases of severe exposure
Carcinogenicity: No available evidence to suggest carcinogenicity in humans
Mutagenicity: Not classified as mutagenic
Reproductive Toxicity: Maternal and fetal development issues possible at high doses based on animal models
Sensitization: May cause allergic reactions in sensitive individuals
Other Hazards: Rare cases of skin rashes, urticaria reported in occupational settings
Ecotoxicity: Toxic to aquatic organisms at moderate concentrations; thyroid hormone disruption observed in fish and amphibian models
Mobility: Low mobility in soil; binds to organic matter and sediment
Persistence and Degradability: Moderately persistent in the environment, subject to biotic and abiotic transformation
Bioaccumulation Potential: Moderate potential for bioaccumulation in aquatic species
Other Adverse Effects: No substantial data for effects on invertebrates or terrestrial wildlife beyond laboratory studies
Precautionary Disposal: Minimize release to environment; avoid direct discharge into water bodies
Waste Disposal Methods: Dispose of in accordance with federal, state, and local environmental control regulations by licensed hazardous waste contractor
Container Handling: Triple-rinse containers, puncture or crush, and dispose as hazardous laboratory waste
Incineration or Secure Landfill: Preferred methods for larger quantities; incinerate in chemical incinerator equipped with afterburner and scrubber
Do Not: Discharge waste material into drains or watercourses; do not dispose in regular municipal waste streams
Advice on Disposal: Align disposal protocol with latest environmental protection agency guidelines and specific site regulations
UN Number: Not specifically classified for transport under UN recommendations
Transport Hazard Class: None assigned under US DOT, IATA, or IMDG; treat as laboratory chemical
Packaging Requirements: Secure in leak-proof, clearly labeled, and chemically resistant containers
Special Transport Precautions: Keep separated from food and feedstuffs; ensure compatible substances are not co-packed
Transport in Bulk: Not applicable for scientific and clinical quantities
Label: Chemical reference material, handle as potentially hazardous
US Regulation: Not regulated as a specific hazardous material by OSHA under 29 CFR 1910; SARA Title III Section 313 does not list iodothyronines
EU Regulation: Not classified under Regulation (EC) No 1272/2008 (CLP); Pharmaceutically restricted substances per EU REACH registration for precursors
Canada: Not subject to WHMIS classification criteria; reportable under Controlled Products Regulations for lab chemicals
Other National Inventories: Listed as laboratory and pharmaceutical chemical in key chemical inventory lists (TSCA, DSL, EINECS/ELINCS)
Notes: Consult local and national regulations for restrictions on import, export, use, and disposal
