© 2026 Alchemist Worldwide Ltd,
All Right Reserved
Product Name: Indometacin
Chemical Name: 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
CAS Number: 53-86-1
Molecular Formula: C19H16ClNO4
Supplier: [Company contact info]
Use: Pharmaceutical, Nonsteroidal Anti-Inflammatory Drug (NSAID)
Classification: Acute Toxicity (Oral), Category 4; Eye Irritation, Category 2A; Skin Irritation, Category 2; Specific Target Organ Toxicity (Repeated Exposure), Category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes serious eye irritation. Causes skin irritation. May cause damage to organs through prolonged or repeated exposure.
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust. Wash hands thoroughly after handling. Wear protective gloves and eye protection. Do not eat, drink, or smoke when using this product. If in eyes, rinse cautiously with water.
Chemical: Indometacin
Concentration: >98% (pure substance)
CAS Number: 53-86-1
Impurities: Trace related compounds and stabilizers less than 2%
Inhalation: Move person to fresh air. Seek medical attention if respiratory symptoms develop. Monitor breathing.
Skin Contact: Remove contaminated clothing. Wash skin immediately with soap and water. Seek medical advice if irritation persists.
Eye Contact: Rinse cautiously with water, lifting eyelids. Remove contact lenses if present and easy to do. Seek medical attention for persistent irritation.
Ingestion: Rinse mouth with water. Do not induce vomiting. Seek medical help; show label or SDS to medical personnel.
Most Important Symptoms/Effects: Gastrointestinal disturbances, central nervous system effects, eye and skin irritation.
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide.
Unsuitable Media: Direct water jet (spreads powder).
Specific Hazards: Emits harmful fumes under fire conditions, such as nitrogen oxides, carbon monoxide, and hydrogen chloride gas.
Protection for Firefighters: Use self-contained breathing apparatus and protective clothing.
Special Procedures: Avoid inhalation or skin contact with combustion products. Cool containers near fire with spray.
Personal Precautions: Evacuate area if needed. Use personal protective equipment including gloves, goggles, and mask. Avoid dust formation.
Environmental Precautions: Prevent powder from entering waterways, storm drains, or soil.
Methods for Cleanup: Sweep up using tools that minimize dust generation. Place in suitable, closed containers for disposal. Clean spill area thoroughly with water.
Reporting: Inform authorities if large amounts contaminate the environment.
Handling: Handle in a well-ventilated area. Avoid inhalation of dust. Prevent contact with skin, eyes, and clothing. Do not eat, drink, or smoke while handling.
Hygiene Measures: Wash hands before breaks and after handling.
Storage Conditions: Store in tightly closed original container, in a cool, dry place away from heat, direct sunlight, and incompatible substances (such as strong oxidizers).
Storage Class: Chemical storage, not with food or drink.
Occupational Exposure Limits: No specific exposure limit values established for indometacin. Use recognized limits for pharmaceutical dust: nuisance dust TLV 10 mg/m³ (total), 3 mg/m³ (respirable).
Engineering Controls: Local exhaust ventilation or general ventilation for handling bulk powder.
Personal Protection: Protective gloves, safety goggles, lab coat. Respirator in high-dust scenarios (P2/P3 filter recommended).
Environmental Controls: Avoid releases to environment. Use spill trays and secondary containment for bulk amounts.
Appearance: White to pale yellow crystalline powder
Odor: Odorless
pH (solution): Slightly acidic (pH 4.5–5.5 in water)
Melting Point: 158–162°C
Boiling Point: Not available (decomposes)
Flash Point: Not highly flammable
Solubility: Slightly soluble in water, soluble in acetone, ethanol, and methanol
Vapor Pressure: Negligible at room temperature
Relative Density: About 1.38 g/cm³
Partition Coefficient (log Pow): 4.27
Stability: Stable under recommended storage and handling conditions.
Reactivity: No dangerous reactions under normal use. Avoid strong oxidizers.
Conditions to Avoid: High humidity, heat, open flame.
Decomposition Products: Hazardous gases such as hydrogen chloride, nitrogen oxides, carbon oxides under fire or extreme heat.
Polymerization: Does not occur.
Acute Toxicity: Oral LD50 (rat) ~50 mg/kg. Harmful if swallowed in significant quantity.
Chronic Toxicity: Prolonged exposure causes gastrointestinal, liver, and kidney effects; possible blood formation disturbances.
Irritation: Causes eye and skin irritation in animal studies and in humans.
Sensitization: No strong evidence for skin sensitization in humans.
Carcinogenicity: Not classified as a human carcinogen based on available studies.
Mutagenicity: Negative in bacterial and mammalian test systems.
Reproductive Toxicity: Can affect fetus based on animal studies at high doses.
Ecotoxicity: Toxic to aquatic organisms. LC50 (fish) 5.9 mg/L (96 h). EC50 (daphnia) 0.36 mg/L (48 h).
Persistence and Degradability: Not readily biodegradable; expected to persist in aquatic systems.
Bioaccumulation Potential: May accumulate in aquatic organisms (log Pow >3).
Mobility in Soil: Limited mobility; binds moderately to soil particles.
Other Adverse Effects: Pharmaceuticals such as indometacin may impact wastewater microorganisms.
Waste Treatment Methods: Dispose of as pharmaceutical waste. Do not release into drains or the environment.
Disposal Containers: Use properly labeled, sealed containers.
Incineration: Dispose of through licensed chemical waste incinerator.
Contaminated Packaging: Dispose of containers as hazardous waste, using appropriate procedures.
UN Number: Not assigned for pharmaceutical substances in finished dosage form.
Proper Shipping Name: Indometacin
Transport Hazard Class: Not classified as dangerous for transport (ADR, RID, IATA, IMDG).
Packing Group: Not regulated
Special Precautions: Avoid release to environment. Ship in well-sealed containers protected from moisture and sunlight.
EU Regulation: Not listed as a hazardous substance under CLP (Regulation (EC) No 1272/2008)
US Regulation: Subject to OSHA Hazard Communication Standard. Listed in TSCA inventory for research uses.
Other National Regulations: Listed in pharmacopoeias. Subject to pharmaceutical control regulations.
Restrictions: Use and disposal regulated for pharmaceuticals. Handle according to Good Manufacturing Practice (GMP) where applicable.
