Product Name: Indigotine
Other Names: Indigo Carmine, Acid Blue 74, FD&C Blue No. 2
Chemical Formula: C16H8N2Na2O8S2
CAS Number: 860-22-0
Recommended Use: Coloring agent in food, pharmaceuticals, cosmetics
Manufacturer: Supplier contact details printed on package label
Classification: Not classified as hazardous according to current GHS standards
Hazards: Dust may irritate eyes, skin, respiratory tract. Skin contact can result in mild irritation for sensitive individuals. Inhalation of powder may cause coughing or sneezing. Accidental ingestion in significant amounts may trigger nausea, stomach discomfort, or diarrhea.
Label Elements: No signal word required, no pictograms, precautionary statements focus on avoiding inhalation of dust and contact with eyes.
Symptoms: Eye redness, skin itchiness, mild respiratory discomfort with dust exposure
Other Risks: Not known to be carcinogenic, mutagenic, or reproductive toxigen
Main Ingredient: Indigotine (C16H8N2Na2O8S2)
Purity: Typically above 85%
Impurities: May contain trace sodium chloride, sodium sulfate, and unreacted starting materials (below reporting limits)
Physical Appearance: Blue powder or granules
Common Synonyms: Indigo carmine, Acid blue 74, Dinatrium-3,3'-dioxo-2,2'-biindoline-5,5'-disulfonate
Additives: None reported for pure form
Eye Contact: Flush eyes with running water for 10–15 minutes; remove contact lenses if present and seek medical advice if irritation persists
Skin Contact: Wash skin with mild soap and water; remove contaminated clothing; seek medical attention for continued irritation
Inhalation: Move to fresh air; rinse mouth and nose with water, consult a healthcare provider if symptoms continue such as coughing or difficulty breathing
Ingestion: Rinse mouth with water, drink water to dilute, do not induce vomiting, seek medical attention if unwell or large quantities consumed
Note to Physicians: Treat symptomatically; most effects expected to resolve with washout and supportive care
Suitable Extinguishing Media: Use dry chemical, carbon dioxide, water spray, or foam; do not use water jet for large fires
Specific Hazards: During burning, toxic fumes of nitrogen oxides and sulfur oxides may form
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear; avoid inhalation of combustion vapors
Additional Advice: Move containers from fire area if possible; avoid runoff of contaminated fire water into drains or natural waterways
Personal Precautions: Use appropriate protective equipment, prevent dust buildup, ensure adequate ventilation
Environmental Precautions: Prevent release into drains, soil, or water bodies; contain spill using barriers, sweep carefully to avoid dust
Cleanup Methods: Collect with shovel or vacuum; place in suitable, sealable containers for waste disposal; wipe area with damp cloth to remove residues
Spill Notification: Inform appropriate local authorities if significant spill threatens drainage or soil
Safe Handling: Avoid breathing powder or dust, avoid skin and eye contact, wear laboratory coats, gloves, safety goggles
Storage: Store in original, tightly closed container in cool, dry, and well-ventilated space, away from incompatible materials like strong oxidizers
Best Practices: Keep away from food, feed, and beverages. Do not reutilize empty packaging; label all containers clearly.
Engineering Controls: Use local exhaust ventilation to minimize airborne dust levels; maintain good industrial hygiene
Personal Protective Equipment: Eye protection (goggles), protective gloves, laboratory coat for skin and clothing protection; use dust mask if handling large quantities
Occupational Exposure Limits: No specific limits for Indigotine established by OSHA, NIOSH, or ACGIH
Special Hygiene Measures: Wash hands thoroughly after use, avoid eating, drinking, or smoking in areas where Indigotine is handled or stored
Form: Powder or granules
Color: Deep blue to blue-violet
Odor: Odorless
pH (aqueous solution): 7–9
Melting Point: Decomposes above 300°C
Solubility: Soluble in water; slightly soluble in ethanol
Density: About 0.7–1.2 g/cm³
Flash Point: Not flammable
Other Properties: Stable under recommended conditions; dust can become airborne easily
Chemical Stability: Stable under normal use and storage conditions
Reactivity: No dangerous reactions under expected usage
Conditions to Avoid: Excess heat, open flames, direct sunlight, moisture
Incompatible Materials: Strong oxidizing agents, strong acids
Hazardous Decomposition Products: Sulfur oxides, nitrogen oxides released if substance burns or decomposes at very high temperatures
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Acute Toxicity: Generally recognized as low toxicity; large doses may cause gastrointestinal upset
Skin/Eye Irritation: May cause mild irritation after contact. Reactions usually resolve with simple first aid
Respiratory Effects: Inhalation of dust may lead to nose and throat irritation
Chronic Exposure: No known significant long-term health effects linked to workplace exposures; not mutagenic, carcinogenic, or toxic for reproduction based on available research
Sensitization: Not considered a skin or respiratory sensitizer
Ecotoxicity: Large quantities may cause harmful effects to aquatic life, especially in confined or stagnant water environments
Persistence and Degradability: Moderately persistent in the environment; low rate of natural biodegradation
Potential for Bioaccumulation: Expected to be low due to water solubility and large molecular size
Mobility in Soil: Likely to remain in aqueous phase; moderate mobility expected
Precautionary Actions: Avoid large releases to soil or water bodies to prevent unnecessary environmental buildup
Waste Treatment Methods: Dispose in accordance with local, regional, and national regulations. Never dump into drains or watercourses.
Contaminated Packaging: Rinse containers thoroughly before recycling or disposal; do not reuse packaging for food or drinking water
Special Instructions: Seek advice from licensed waste disposal contractor for handling of bulk residues or contaminated absorbents
UN Number: Not classified as dangerous goods under most transport regulations
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not applicable
Packing Group: Not regulated
Environmental Hazards: Not classified as marine pollutant
Special Precautions: Ship in tightly sealed, labeled containers; ensure cargo is protected from moisture and dust
US FDA: Approved for use as food colorant FD&C Blue No. 2 (21 CFR 74.3602)
EU Regulation: Food additive E132, permitted in specified quantities
OSHA: Not listed as hazardous
SARA Title III: Not subject to reporting
TSCA: Listed
Other National Standards: Compliant with major regulatory frameworks for food, cosmetic, and pharmaceutical applications
Workplace Labels: Should clearly identify the substance by approved name and hazard information where applicable