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Product Name: Icosapent Ethyl (E-EPA)
Synonyms: Ethyl (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-icosapentaenoic acid ester
CAS Number: 86227-47-6
Molecular Formula: C22H34O2
Intended Use: Pharmaceutical intermediate, active pharmaceutical ingredient
Manufacturer: [information as per supplier]
Contact Telephone: [provided by supplier]
Emergency Telephone: [manufacturer/emergency contact]
Classification: Not classified as hazardous under GHS for typical handling
Hazards: May cause mild irritation to eyes and skin upon direct contact
Signal Word: None required
Hazard Statements: Exposure may result in slight discomfort, such as redness or dryness of the skin
Precautionary Statements: Use standard precautions, avoid direct eye or prolonged skin contact, not expected to present inhalation hazards during normal operations
Pictograms: None required
Chemical Name: Icosapent Ethyl
Common Name: E-EPA
Concentration: >98% purity
CAS Number: 86227-47-6
Impurities/Additives: Trace amounts of related fatty acid esters and corresponding free acids
Eye Contact: Flush immediately with plenty of water for at least 15 minutes, seek medical attention if irritation persists
Skin Contact: Remove contaminated clothing, wash affected area with soap and water, consult a doctor if irritation continues
Inhalation: Move away from exposure, into fresh air, get medical advice if any symptoms develop
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by medical personnel, seek medical assistance
Most Important Symptoms: Temporary eye or skin irritation
Immediate Medical Attention Required: No special recommendations beyond symptomatic care
Suitable Extinguishing Media: Foam, dry chemical, CO2, water spray
Unsuitable Media: Do not use direct water jet that may spread burning material
Hazardous Combustion Products: Carbon dioxide, carbon monoxide, possible traces of organic vapors
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective clothing
Special Hazards: May form slippery surfaces if spilled, slight risk of combustion in intense fire
Personal Precautions: Wear appropriate protective gloves and safety goggles, avoid skin and eye contact
Environmental Precautions: Prevent product from entering drains, surface water, or soil
Spill Cleanup Methods: Absorb spilled liquid using inert material, sweep up and place in a suitable closed container for disposal, ventilate area
Additional Advice: Wash contaminated surfaces with mild detergent and water
Handling: Keep away from sources of ignition, handle in a well-ventilated area, wear standard laboratory protection
Storage: Store in a cool, dry, and well-ventilated area, tightly closed container away from sunlight and strong oxidizers
Incompatible Materials: Strong oxidizing agents, strong acids or bases
Other Precautions: Avoid freezing and searing temperatures that could degrade the product
Exposure Limits: No established occupational exposure limits
Engineering Controls: Ensure adequate ventilation, local exhaust recommended where available
Personal Protective Equipment: Chemical-resistant gloves, lab coat, safety goggles
Hygiene Measures: Wash hands after handling, remove contaminated clothing before eating or drinking
Environmental Exposure Controls: Minimize release to environment by proper handling and containment
Appearance: Pale yellow to clear oily liquid
Odor: Faint, characteristic, mild odor
Odor Threshold: Not established
pH: Not applicable (non-aqueous)
Melting Point/Freezing Point: Below 0°C
Boiling Point/Range: Above 250°C
Flash Point: >200°C
Evaporation Rate: Negligible under normal conditions
Flammability (solid/gas): Not applicable
Vapor Pressure: Very low at ambient temperature
Vapor Density: Not determined
Density/Specific Gravity: 0.89 – 0.92 g/cm³
Solubility: Practically insoluble in water, soluble in organic solvents (ethanol, hexane)
Partition Coefficient (n-octanol/water): High (logP >7)
Auto-ignition Temperature: Not established
Decomposition Temperature: Not determined
Viscosity: Oily, moderate viscosity
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Not known to be reactive under normal usage
Conditions to Avoid: Strong heat, direct sunlight, incompatible chemicals
Incompatible Materials: Strong oxidizers, acids, alkalis
Hazardous Decomposition Products: Possible evolution of carbon monoxide and carbon dioxide on combustion
Polymerization: Will not occur under standard procedures
Acute Toxicity: Based on available data, product has low acute oral and dermal toxicity
Skin Corrosion/Irritation: May cause slight skin irritation after prolonged contact
Serious Eye Damage/Irritation: Mild eye irritant possible
Respiratory/Skin Sensitization: Not expected to be a sensitizer based on similar materials
Germ Cell Mutagenicity: No evidence of mutagenicity found in standard tests
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, OSHA
Reproductive Toxicity: No adverse reproductive effects observed in animal studies
Target Organ Toxicity: No target organ effects observed
Other Harmful Effects: Not identified at normal exposure levels
Ecotoxicity: Product shows low toxicity to aquatic life in acute studies, but large spills may cause environmental harm due to oxygen depletion
Persistence and Degradability: Readily biodegradable under aerobic conditions
Bioaccumulative Potential: Likely to bioaccumulate due to high partition coefficient
Mobility in Soil: Limited mobility due to low water solubility
Other Adverse Effects: Not expected to produce significant environmental impacts under intended use, caution advised to minimize release
Waste Disposal Methods: Dispose of in accordance with local, state, and federal regulations, avoid discharge to sewers or natural waters
Contaminated Packaging: Rinse empty containers with suitable solvent, dispose of as chemical waste
Special Precautions for Landfill/Incineration: Incineration preferred for final disposal if permitted by authorities
UN Number: Not regulated
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not regulated for ground, air, or sea transport
Packing Group: Not assigned
Marine Pollutant: Not a marine pollutant under IMDG
Special Precautions: Protect from extreme heat and freezing, secure containers during transport to prevent leaks
TSCA Status: Listed or meets U.S. EPA exemption criteria
European Inventory (EINECS/ELINCS): Listed
REACH Registration: Registered or exempted
SARA 313/302/304: Not subject to reporting
California Proposition 65: Not listed
Other National Chemical Lists: Included on Australia, Canada, Japan, Korea, Philippines, and China inventories
Labelling Requirements: Not required under OSHA Hazard Communication Standard for non-hazardous chemical
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
