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Product Name: Ice Structuring Protein
Chemical Name: Polypeptide Ice Structuring Agent
Synonyms: Antifreeze Protein, ISP
Recommended Uses: Food ingredient, cryopreservation, biotechnology
Supplier: Contact regional distributor or manufacturer
Emergency Contact: Refer to local emergency number or poison control
CAS Number: Varies by protein source (typically 9007-20-9 for fish-derived ISP)
GHS Classification: Not classified as hazardous
Signal Word: None required
Hazard Statements: No significant hazards identified under normal conditions
Precautionary Statements: Prevent inhalation of dust, prevent contact with eyes
Other Hazards: May cause mild irritation in sensitive individuals; avoid excessive inhalation or ingestion of large amounts outside intended food use
Label Elements: No pictograms mandated for typical ISP as a food-grade material
Routes of Exposure: Oral (if not intended for food, or in large amounts), dermal, inhalation (dust form)
Substance: Purified protein derived from biological sources (fish, plants, yeast)
Ingredient: Ice Structuring Protein (Purity > 95%)
Impurities: Trace residual carbohydrates, salts from purification process
Allergens: Source-dependent; check product literature for fish, yeast, or plant origin
Other Components: Water (where in solution), minimal buffer agents (if supplied in liquid form)
Inhalation: Move exposed individual to fresh air. If respiratory discomfort develops, consult medical advice.
Skin Contact: Wash with soap and water. Remove contaminated clothing.
Eye Contact: Rinse thoroughly with water for several minutes. Seek medical attention if irritation persists.
Ingestion: Rinse mouth; for accidental ingestion of large amounts (non-food grade), seek medical assessment.
Note to Physicians: Symptomatic treatment based on exposure severity.
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: None known for this protein
Special Hazards: Product will burn if involved in a fire; protein decomposition may release nitrogen and sulfur compounds
Protective Equipment: Standard protection for chemical fires—self-contained breathing apparatus and protective gear
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, oxides of nitrogen, sulfur oxides
Special Procedures: Keep containers cooled with water spray if possible, prevent runoff from entering waterways
Personal Precautions: Wear dust mask, safety glasses, and gloves. Avoid breathing dust.
Protective Equipment: As above, with lab coat or disposable suit for significant spills.
Spill Cleanup Methods: Sweep up gently to avoid generating dust. Store in proper container for disposal or recovery.
Environmental Precautions: Prevent entry into drains or watercourses; although low ecological risk, minimize contamination.
Decontamination: Wash spill site with water and mild detergent after cleanup.
Handling: Work in well-ventilated area, minimize dust generation, avoid contact with eyes or broken skin.
Hygiene Recommendations: Wash hands before eating, drinking, or smoking. Remove contaminated clothing after use.
Storage Conditions: Store in sealed containers, keep dry and cool, avoid direct sunlight, maintain at suggested storage temperature (2-8°C for lyophilized powder, frozen for some solutions).
Incompatible Materials: Strong oxidizers and acids
Technical Measures: Use with adequate ventilation, employ dust extraction where necessary.
Exposure Limits: Not established for this protein in any jurisdiction
Engineering Controls: Local exhaust ventilation or laboratory fume hood recommended for large-scale or repeated handling
Personal Protective Equipment: Safety goggles, gloves (nitrile or latex), dust mask or respirator if working with significant dust
Environmental Protection: Avoid release of dust to air or effluent to environment
Appearance: White or off-white powder or crystalline lyophilized mass; clear or slightly opalescent solution if in liquid form
Odor: Odorless or very slight proteinaceous smell
pH: 5.5–8.0 (aqueous solution)
Melting Point/Range: Denaturation above 55–70°C (source-specific)
Boiling Point: Not applicable
Solubility: Soluble in water
Vapor Pressure: Not relevant
Specific Gravity: ~1.3 (where measurable)
Partition Coefficient: Not determined
Flash Point: Not flammable under standard conditions
Decomposition Temp: Above 70°C (protein degradation possible)
Chemical Stability: Stable under recommended handling and storage conditions
Possibility of Hazardous Reactions: No dangerous reactions expected with standard laboratory chemicals
Material Incompatibility: Strong acids, oxidizers
Conditions to Avoid: Heat, moisture (for powder), direct sunlight, freezing/thawing cycles for solution
Hazardous Decomposition Products: Combustion or decomposition may release carbon monoxide, carbon dioxide, nitrogen oxides
Acute Toxicity: No evidence of toxicity in standard models; no LD50 established for typical ISP
Chronic Effects: No chronic effects reported from dietary or laboratory use
Potential Health Effects: May cause minor irritation to skin, eyes, or respiratory tract if exposed to large quantities of dust
Carcinogenicity: No carcinogenicity reported for protein
Mutagenicity: Not expected based on protein structure and food-grade evaluation
Sensitization: Possible rare allergic reactions, especially for proteins derived from known allergen sources such as fish
Target Organs: No specific organ toxicity
Aquatic Toxicity: Not significantly toxic to aquatic life based on proteinaceous nature
Persistence and Degradability: Biodegradable; readily degraded by environmental microbes and enzymes
Bioaccumulation Potential: Not bioaccumulative; proteins are metabolized by most organisms
Mobility in Soil: High as dissolved or colloidal material in water; no specific soil toxicity
Further Ecological Information: Unlikely to cause adverse effects at typical release concentrations in environment
Waste Disposal Methods: Dispose of in accordance with local, state, and national regulations
Product Disposal: In small amounts, may be disposed of as non-hazardous laboratory waste; larger quantities into incineration or approved landfill
Container Disposal: Rinse containers before recycling or disposal
Special Precautions: None required for standard handling; avoid environmental release of significant volumes
UN Number: Not regulated as a dangerous good
Transport Hazard Class: Not classified
Packing Group: Not applicable
Labeling Requirements: None required for standard ISP shipments
Shipping Name: Ice Structuring Protein or Proteinaceous Food Additive
Special Transport Precautions: Avoid exposure to moisture and heat during transport; use chilled shipping for solutions or sensitive preparations
Inventory Status: Included in food additive inventories or biotechnological substance lists in many jurisdictions
TSCA (USA): No specific listing; proteins generally exempt for food and research use
EU REACH: Many ISPs considered food ingredients, not subject to substance registration
Specific Food Codex: Approved for food use in several regions (e.g., FAO/WHO Codex, EFSA, FDA Approval for certain uses)
Labeling Requirements: Source disclosure required for allergens (fish, plant, yeast)
Worker Protection Regulation: Follow standard biosafety protocols for protein handling
Other Regulatory Controls: Subject to local food safety, environmental, and occupational safety rules
