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Product Name: Hyaluronic Acid
Chemical Name: Sodium Hyaluronate
Synonyms: Hyaluronan, Hyaluronate
Recommended Uses: Dermal filler, ophthalmic agent, joint health supplement, cosmetics, wound care
Company Identification: Manufacturer and distributor details found on product label
Contact Information: Supplier emergency phone number and address as listed on packaging
CAS Number: 9067-32-7
UN Number: Not regulated as a hazardous material under UN criteria
GHS Classification: Not classified as hazardous under GHS
Signal Word: None required
Hazard Statements: Product may induce mild irritation on direct contact with sensitive skin or eyes
Precautionary Statements: Avoid contact with eyes, prolonged inhalation of dust may irritate respiratory tract
Symptoms of Exposure: Itching, mild redness, slight watering of eyes, cough from dust exposure
Pictograms: Not required
Other Hazards: Dust may pose slip hazard and cause mild nuisance
Chemical Structure: Polysaccharide chain of repeating disaccharide units
Typical Purity: Greater than 95% sodium hyaluronate
Impurities: Trace quantities of proteins, other glycosaminoglycans
Percentage by Weight: Hyaluronic acid >95%, moisture content varies 5-15%
Eye Contact: Rinse immediately with clean water for several minutes, remove contact lenses, seek medical attention for persistent irritation
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing
Inhalation: Move to fresh air, seek medical advice if persistent cough or irritation develops
Ingestion: Rinse mouth, drink plenty of water to dilute, consult a physician if large quantities are swallowed or discomfort occurs
Advice for Physicians: Symptomatic treatment as required, product is biologically compatible, allergic reactions are rare but possible
Suitable Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide
Unsuitable Extinguishing Media: Direct jet of water can scatter powder, increasing clean-up
Special Hazards: Dust may form explosive mixtures with air
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, possible low molecular weight organics
Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective gear
Special Precautions: Contain water used for fighting fire, avoid entry to drains and watercourses
Personal Precautions: Wear suitable protective clothing, dust mask, and gloves
Environmental Precautions: Prevent entry into soil, drains, and watercourses
Methods for Clean-up: Sweep or vacuum up material, avoid creating dust, collect in a closed container for disposal
Decontamination Procedures: Wash area with copious amounts of water after clean-up to avoid residual slip hazard
Emergency Procedures: Evacuate area if significant dust generated or spill is large
Handling: Minimize dust generation and accumulation, avoid inhalation and contact with eyes, use local exhaust ventilation
Storage: Store in tightly closed containers in a cool, dry, well-ventilated place away from heat sources and incompatible materials
Incompatible Materials: Strong oxidizers, strong acids, bases
Special Storage Precautions: Protect from moisture, sunlight, and excessive temperature changes
Other Considerations: Keep out of reach of children, use within recommended shelf life date
Occupational Exposure Limits: Not established for hyaluronic acid; general dust limits may apply (OSHA PEL: 15 mg/m3 total dust; 5 mg/m3 respirable dust)
Engineering Controls: Local exhaust ventilation to control airborne particulates
Personal Protective Equipment: Safety glasses, gloves, lab coat or apron; dust mask or respirator where airborne concentrations are high
Hygiene Measures: Wash hands thoroughly after handling, do not eat, drink, or smoke during use
Environmental Controls: Avoid release to environment, comply with emissions regulations
Appearance: White to off-white powder or fibrous substance
Odor: Odorless
pH (1% solution): 6.0–8.0
Boiling Point: Not applicable
Melting Point: Decomposes before melting
Solubility: Soluble in water, forms viscoelastic solutions
Density: 0.5–0.8 g/cm3 (bulk density)
Viscosity: High for aqueous solutions
Flash Point: Not applicable
Auto-ignition Temperature: Not determined
Explosion Limits: Dust can explode if suspended in air in sufficient concentrations and ignited
Partition Coefficient: Not applicable
Chemical Stability: Stable under recommended storage conditions
Conditions to Avoid: Exposure to heat, moisture, direct sunlight, open flames, and strong oxidizing agents
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition Products: Thermal decomposition produces carbon monoxide, carbon dioxide, nitrogen oxides
Polymerization: Does not undergo hazardous polymerization
Acute Toxicity: Oral LD50 (rat): >2,000 mg/kg; low acute toxicity expected
Skin Irritation: Not a primary skin irritant, mild irritation possible with repeated exposure
Eye Irritation: Mild, transient irritation possible
Inhalation: Excessive dust may cause upper respiratory tract irritation
Sensitization: Sensitizing reactions are rare
Chronic Effects: No chronic toxicity or carcinogenicity reported, product is part of normal connective tissue
Mutagenicity: Negative data in standard in vitro and in vivo tests
Reproductive Toxicity: No evidence of reproductive effects
Ecotoxicity: Not expected to be hazardous to the environment under normal conditions of use
Aquatic Toxicity: Not identified as harmful to aquatic organisms based on available data
Persistence and Degradability: Readily biodegradable, natural polysaccharide
Bioaccumulation Potential: Low, product metabolizes and breaks down in the environment
Mobility in Soil: High water solubility, mobile in the aqueous phase but will degrade
Other Adverse Effects: None known
Waste Disposal Methods: Dispose of product and packaging in accordance with local, regional, and national regulations
Product Disposal: May be landfilled or incinerated, avoid release to watercourses
Container Disposal: Empty containers may be disposed or recycled after thorough cleaning
Special Precautions: Avoid dust generation during disposal, ensure proper PPE is worn
UN Number: Not regulated
Proper Shipping Name: Hyaluronic Acid
Transport Hazard Class: Not classified
Packing Group: Not applicable
Marine Pollutant: No
Transport in Bulk: Follow local regulations
Special Transport Precautions: Protect from moisture and heat during transport
Relevant Regulations: Not classified as hazardous, does not appear on major chemical control lists
US Federal Regulations: Not listed as hazardous under OSHA, TSCA inventory listed
EU Regulations: Not classified as hazardous, REACH compliant
Other Regulatory Status: Meet requirements for use in cosmetics, injectable medical devices, and foods where permitted
Labeling Requirements: Product must be correctly labeled according to relevant jurisdiction
Workplace Codes: General chemical hygiene practices apply
