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Material Safety Data Sheet: Hemin

Identification

Product Name: Hemin
Chemical Formula: C34H32ClFeN4O4
Other Identifiers: Hydrochloride of Heme
CAS Number: 16009-13-5
Use: Laboratory reagent, research, some medicinal applications
Manufacturer/Supplier: Check supplier details on packaging
Emergency Information: Local emergency line or poison control center

Hazard Identification

GHS Classification: Acute toxicity (oral, dermal), Eye irritation, Hazardous to aquatic environment
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation. May cause respiratory tract irritation. Harmful if swallowed.
Pictograms: Exclamation mark, Environment
Precautionary Statements: Wear protective clothing, avoid inhaling dust, avoid release to environment.

Composition / Information on Ingredients

Chemical Name: Hemin
Chemical Family: Porphyrin iron complex
Concentration: 100% (pure substance)
Impurities: Trace solvent or chloride from synthesis, varies by batch but present at very low levels

First Aid Measures

Inhalation: Move person to fresh air, seek medical attention for persistent symptoms.
Skin Contact: Wash area with soap and water, take off contaminated clothing, seek help for ongoing irritation.
Eye Contact: Rinse under running water for at least 15 minutes, keep eyes open, get medical advice.
Ingestion: Do not induce vomiting, rinse mouth, seek immediate medical help.

Fire-Fighting Measures

Extinguishing Media: Dry chemical, CO2, foam, water spray
Hazards in Fire: Toxic fumes of iron oxides, nitrogen oxides, chlorine compounds
Protective Equipment: Full protective suit, self-contained breathing apparatus
Advice: Move away from fire area, avoid inhaling fumes, cool containers with water spray

Accidental Release Measures

Personal Protection: Use gloves, goggles, dust mask or respirator as needed
Environmental Precautions: Prevent runoff to waterways, keep away from drains
Spill Response: Sweep up gently, avoid raising dust, collect in sealable container, wash area with water

Handling and Storage

Handling: Avoid skin and eye contact, use in ventilated space, keep away from food and drink
Storage Conditions: Store tightly sealed in cool, dry, dark place; keep container clearly labeled
Incompatible Materials: Strong oxidizers, acids

Exposure Controls and Personal Protection

Engineering Controls: Work with local exhaust or ventilation, use fume hood if available
Personal Protective Equipment: Gloves (nitrile or latex), safety goggles, lab coat
Hygiene Measures: Wash hands after use, do not eat or smoke in work area

Physical and Chemical Properties

Appearance: Dark reddish-brown to black solid, metallic sheen
Odor: Odorless
Melting Point: Decomposes above 280°C
Solubility: Slightly soluble in water, dissolves in alkaline solutions
Specific Gravity: About 1.7
pH: Slightly acidic in solution
Vapor Pressure: Not applicable
Partition Coefficient: Not available

Stability and Reactivity

Chemical Stability: Stable under normal storage and handling conditions
Reactivity: Does not react violently with water or most common chemicals
Incompatible Substances: Strong acids, strong oxidizers
Decomposition: At high temperatures, forms iron oxides, nitrogen oxides, chlorine gas

Toxicological Information

Routes of Exposure: Inhalation, skin, ingestion
Acute Effects: May cause mild to moderate irritation of eyes, skin, respiratory tract
Chronic Effects: Possible effects on liver, kidneys based on animal studies; risk increases with prolonged exposure
Symptoms: Redness, cough, nausea, abdominal pain
LD50 (oral, rat): Estimated between 500-2000 mg/kg
Sensitization: No reliable human data available

Ecological Information

Environmental Impact: Can be toxic to aquatic organisms at higher concentrations
Mobility: Not highly mobile in soil
Degradability: Partially biodegradable
Bioaccumulation: Low potential, but iron can persist in environments
Aquatic Toxicity: Acute toxicity to certain invertebrates and fish

Disposal Considerations

Disposal Methods: Treat as hazardous waste according to local, regional, or national guidelines
Do not: Dispose into drains, watercourses, or regular garbage
Packaging Disposal: Dispose of containers as hazardous waste if contaminated

Transport Information

UN Number: Not regulated under most transport laws
Shipping Name: Hemin
Hazard Class: Not classified as hazardous for air, sea, or land shipment
Packing Group: Not assigned
Precautions: Keep container tightly closed, labeled, protect from physical damage and moisture

Regulatory Information

Labeling Requirements: Follows OSHA Hazard Communication Standard, GHS guidelines
TSCA Inventory: Listed
EU REACH Status: Registered or preregistered (check supplier)
Other Regulatory Listings: Check local, regional, national chemical inventories for current status and any restrictions
Workplace Safety: Follow workplace exposure guidelines as set by authorities