Product Name: Glycerine
Synonyms: Glycerol, 1,2,3-Propanetriol
Chemical Formula: C3H8O3
CAS Number: 56-81-5
Uses: Pharmaceuticals, food industry, cosmetics, personal care, industrial solvents, antifreeze, tobacco products, chemical intermediates
Manufacturer: Refer to supplier label
Emergency Contact: Refer to local emergency information
Classification: Not classed as hazardous according to GHS
Physical Hazards: Non-flammable in liquid state, but burns if heated strongly
Health Hazards: May cause mild eye irritation, repeated inhalation of mists may irritate respiratory tract, ingestion of large amounts may cause headache, dizziness, nausea, excessive thirst
Environmental Hazards: Generally low toxicity for aquatic life
Signal Word: None required under GHS
Hazard Statements: None under GHS classification
Precautionary Statements: Avoid breathing mist, wash hands after handling, avoid contact with eyes
Chemical Name: Glycerol
Concentration: 98–100%
Impurities: Water (up to 2%), trace organic substances
EC Number: 200-289-5
Hazardous Components: Not applicable – contains no hazardous impurities above relevant cutoffs
Inhalation: Move exposed person to fresh air, seek medical attention if symptoms persist
Skin Contact: Rinse skin with water, seek medical help if irritation develops
Eye Contact: Rinse eyes slowly and gently with plenty of water for several minutes, seek medical attention if irritation or pain continue
Ingestion: Rinse mouth with water, drink water to dilute, do not induce vomiting, get medical advice if large amounts consumed or symptoms develop
Symptoms: May include nausea, headache, dryness of mouth and throat, respiratory discomfort if mist inhaled
Recommendations for Physicians: Treat symptomatically
Suitable Extinguishing Media: Use carbon dioxide, dry powder, foam, or water spray
Unsuitable Extinguishing Media: Avoid direct water jets due to potential for spreading
Combustion Products: Emits smoke, acrolein, carbon monoxide, carbon dioxide if strongly heated
Fire and Explosion Hazards: Container may rupture under intense heat or fire
Protective Equipment for Firefighters: Wear full protective gear including self-contained breathing apparatus to avoid inhaling hazardous fumes
Firefighting Instructions: Cool closed containers by spraying with water to prevent pressure buildup, contain run-off to prevent environmental contamination
Personal Precautions: Avoid contact with spilled material, wear appropriate protective clothing including gloves and eye protection, ensure proper ventilation
Environmental Precautions: Contain spills to prevent contamination of waterways or soil
Cleanup Procedures: For small spills, absorb with sand, earth, or another inert material, collect and place in suitable container for disposal, clean surface thoroughly with water to prevent slip hazard
Large Spillages: Dike area and pump up as much glycerine as possible, dispose in accordance with local, national, and international regulations
Handling: Handle in a well-ventilated area, keep containers closed to avoid contamination and mist formation, avoid prolonged or repeated skin contact
Storage: Store in tightly closed containers in a cool, dry, well-ventilated area away from incompatible materials like strong oxidizers or acids, keep outside direct sunlight and away from sources of heat and ignition
Specific End Use(s): Follow use recommendations and precautions mentioned on supplier's product documentation or product label
Packaging Materials: Use containers made from stainless steel, glass, or polyethylene for long-term storage
Occupational Exposure Limits: ACGIH TLV: 10 mg/m3 (total mist), OSHA PEL: 15 mg/m3 (total dust/mist); 5 mg/m3 (respirable fraction)
Engineering Controls: Use with adequate general or local exhaust ventilation, especially for mist-producing processes
Respiratory Protection: Not normally required, but use a NIOSH-approved mask if misting occurs or ventilation is inadequate
Eye Protection: Safety glasses with side shields or chemical goggles
Hand Protection: Impervious gloves made from materials such as nitrile, PVC, or neoprene
Skin Protection: Use protective clothing to prevent repeated or prolonged skin contact
Hygiene Measures: Wash hands and exposed skin after handling, remove contaminated clothing and clean before reuse
Appearance: Clear, colorless, viscous liquid
Odor: Odorless or mild sweet smell
Odor Threshold: Not established
pH: Approximately 5.5–8.0 (10% solution in water)
Melting Point: 17.8°C (64°F)
Boiling Point: 290°C (554°F)
Flash Point: 177°C (351°F, closed cup)
Evaporation Rate: Negligible
Flammability: Not readily flammable under ambient conditions
Vapor Pressure: < 0.1 mm Hg at 20°C
Vapor Density: 3.1 (Air = 1)
Relative Density: 1.26 at 25°C
Solubility in Water: Fully miscible
Partition Coefficient (n-octanol/water): -1.76
Auto-ignition Temperature: 370°C (698°F)
Decomposition Temperature: 290°C
Viscosity: Approximately 1,410 mPa·s (20°C)
Reactivity: Glycerine is stable under normal conditions, reacts with strong oxidizing agents, may form potentially hazardous peroxides with reactants like hydrogen peroxide
Chemical Stability: Stable under recommended handling and storage conditions
Possibility of Hazardous Reactions: Reaction with strong oxidizers such as potassium permanganate, chromium trioxide, nitric acid may cause fires or explosions
Conditions to Avoid: Excessive heat, contact with incompatible chemicals
Incompatible Materials: Strong acids, strong bases, oxidizing agents, some plastics
Hazardous Decomposition Products: Acrolein, carbon monoxide, carbon dioxide
Routes of Exposure: Inhalation (as mist), ingestion, skin and eye contact
Acute Toxicity: LD50 (oral, rat): 12,600 mg/kg; Not toxic by skin contact
Chronic Toxicity: No known human carcinogenicity, no evidence for chronic toxic effects at occupational levels
Inhalation: Prolonged exposure to high airborne concentrations may cause headache, dizziness, and mild upper respiratory tract irritation
Ingestion: High doses may cause headache, nausea, diarrhea, thirst
Skin and Eye Contact: Prolonged or repeated contact may cause dryness or slight irritation
Delayed Effects: None documented at relevant exposure levels
Sensitization: Does not cause sensitization
Carcinogenicity: Not listed by IARC, NTP, OSHA, or ACGIH
Other Information: Not considered mutagenic or teratogenic
Ecotoxicity: Low toxicity to aquatic organisms (LC50 (fish, 96 hr): >10,000 mg/L); very low risk in land and water environments when used appropriately
Persistence and Degradability: Glycerine quickly biodegrades in soil and water, both aerobically and anaerobically
Bioaccumulation Potential: Does not accumulate in organisms; log Kow -1.76
Mobility in Soil: High mobility due to full water solubility
Other Adverse Effects: No known significant effects or hazards
Waste Treatment Methods: Glycerine waste should be handled in accordance with all applicable local, regional, and national guidelines
Disposal of Product: Small quantities can be washed away with large amounts of water, preferably to a wastewater treatment system capable of biological degradation; large volumes should be recycled or disposed of through a licensed waste management facility
Disposal of Packaging: Containers should be emptied and can be recycled where local facilities permit, otherwise should be disposed of as non-hazardous waste
Precautions: Avoid entry to sewers or environment in concentrated form
UN Number: Not regulated for transport under UN Model Regulations
Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: Not hazardous
Packing Group: Not applicable
Environmental Hazards: Not classified as marine pollutant
Special Precautions: Keep containers tightly closed, protect from physical damage and extreme temperatures
Regulatory References: Road, rail, air, and sea transport not regulated for glycerine
Global Inventory Status: Listed on US TSCA, Canada DSL, EU EINECS, Australia AICS, China IECSC, Japan ENCS, Korea KECI, Philippines PICCS
SARA Title III: Not subject to reporting for Sections 302, 304, 311, 312, or 313
OSHA: Not classified as hazardous
EU Classification: Not hazardous under Regulation (EC) No. 1272/2008 (CLP/GHS)
REACH Registration: Fully registered
FDA Approval: Acceptable as food additive and pharmaceutical excipient (verify product grade and intended use with supplier)
Other Regulations: No significant regulatory restrictions when used for intended industrial, food, or pharmaceutical applications