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Material Safety Data Sheet (MSDS) for Glutamine Transaminase

Identification

Product Name: Glutamine Transaminase
Synonyms: Glutaminase transaminase, Transaminating enzyme
CAS Number: 9014-19-9
Recommended Use: Laboratory research, biochemical assays, enzymatic syntheses
Manufacturer: [Company Name], [Address], [Contact Info]
Emergency Contact: [Emergency Phone Number]

Hazard Identification

Classification: Not classified as hazardous under GHS criteria for pure enzyme
Physical Hazards: Fine powder may cause dust explosion in high concentrations
Health Hazards: May cause mild irritation to respiratory system, eyes, and skin on prolonged exposure
Environmental Hazards: Low threat to aquatic life in laboratory quantities, but not suitable for direct disposal into environment
Label Elements: No symbol required, precautionary statements for laboratory use
Route of Exposure: Inhalation, skin contact, eye contact

Composition / Information on Ingredients

Chemical Name: Glutamine Transaminase
Purity: >90% as enzyme concentrate
Component: Protein enzyme from recombinant or animal source
Form: Lyophilized powder or buffered solution
Additives: May contain stabilizers such as sodium chloride or buffer salts (commonly phosphate buffers), trace preservatives

First Aid Measures

Inhalation: Move affected person into fresh air, support breathing if necessary, seek medical attention for persistent discomfort
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, monitor for irritation
Eye Contact: Rinse with copious amounts of water for at least fifteen minutes, keep eyelids open, consult ophthalmologist if irritation persists
Ingestion: Rinse mouth, do not induce vomiting, seek medical help especially if large amount swallowed
Note to Physician: Treat symptomatically, allergic reactions are rare but sensitization is possible with repeated exposure

Fire-Fighting Measures

Suitable Extinguishing Media: Water mist, carbon dioxide, dry chemical powder, foam
Unsuitable Extinguishing Media: Direct jet of water can disperse the powder
Special Hazards: Fine dust can ignite in high concentrations, decomposition can produce nitrogen oxides and carbon oxides
Protective Equipment: Wear self-contained breathing apparatus and protective clothing
Firefighting Instructions: Approach from upwind, prevent runoff to water sources, cool containers with water spray to avoid rupture

Accidental Release Measures

Personal Precautions: Avoid creating dust clouds, ventilate area, avoid direct breathing and skin contact
Protective Equipment: Laboratory gloves, eye protection, N95 or equivalent dust mask
Containment: Sweep up gently using damp methods or a vacuum with HEPA filter, avoid dry sweeping
Clean-up Method: Place material in designated waste container for proper disposal, wipe surface with detergent solution to remove residues

Handling and Storage

Handling: Keep containers closed when not in use, work with powder under local exhaust ventilation, avoid inhaling dust, wash hands after use
Storage Conditions: Store at recommended temperature, typically -20°C for long-term or 2-8°C for short-term, keep out of direct sunlight and away from incompatible chemicals
Incompatibilities: Strong oxidizers, acids, bases may denature enzyme
Special Instructions: Do not store with food, drink, or animal feed, label secondary containers, ensure containers are properly sealed to prevent moisture entry

Exposure Controls and Personal Protection

Engineering Controls: Work in well-ventilated areas, use fume hood for open handling of powder
Eye Protection: Safety goggles with side shields
Skin Protection: Lab coats, disposable gloves resistant to chemicals
Respiratory Protection: Certified particulate respirator or dust mask when handling powder form
Hygiene Measures: Wash hands and face after handling, do not eat or drink in work area, remove and wash contaminated clothing

Physical and Chemical Properties

Appearance: White to off-white lyophilized powder or clear, colorless liquid
Odor: Odorless
pH: Neutral to slightly basic for solution
Solubility: Soluble in water and buffered solutions
Boiling Point: Not applicable for enzyme powders
Melting Point: Decomposes before melting
Flash Point: Not flammable in solution form, powder can combust as organic dust
Density: 1.2 – 1.4 g/cm³ for powder
Other Data: Enzyme activity lost above 50°C

Stability and Reactivity

Stability: Stable under recommended storage and handling conditions
Reactivity: Minimal reactivity under standard laboratory conditions
Hazardous Reactions: None documented under ordinary storage and use
Incompatibles: Avoid strong oxidizers, acids, bases, heavy metal salts
Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide upon thermal decomposition
Polymerization: Not known to undergo hazardous polymerization

Toxicological Information

Acute Effects: Inhalation may trigger respiratory or nasal irritation, rare allergies, mild sneeze or cough
Skin Contact: Minor irritation with repeated or prolonged exposure
Eye Contact: Mild irritation, watery eyes, redness
Ingestion: Low toxicity; large ingestion may cause nausea, no specific enzyme-related toxicity evidence in humans
Chronic Effects: Rare sensitization possible among laboratory workers, no chronic toxicity identified
Carcinogenicity: No components classified as carcinogenic by IARC, NTP, OSHA
Mutagenicity / Reproductive Toxicity: Not known to be mutagenic or teratogenic

Ecological Information

Environmental Fate: Biodegradable, breaks down in sewage and natural waters
Toxicity: Expected to have no acute or chronic toxicity in aquatic environments at laboratory levels
Persistence: Not persistent, decomposes in biological systems
Bioaccumulation: Not expected to bioaccumulate
Other Effects: Large spills may boost ammonium or nitrate content in water, best avoided in large-scale releases

Disposal Considerations

Disposal of Product: Rinse small amounts into laboratory drain with copious water if regulations permit; otherwise collect for disposal as chemical waste
Disposal of Contaminated Packaging: Dispose of used containers in line with local, state, and national regulations, rinse before discarding
Special Considerations: Do not mix with incompatible chemicals, do not allow to enter natural waterways in significant concentrations

Transport Information

UN Number: Not regulated as hazardous material for transport
UN Proper Shipping Name: Not restricted
Transport Hazard Class: Non-hazardous
Packing Group: Not assigned
Transportation Notes: Ship in temperature-controlled conditions if required, avoid breakage, use secondary containment when shipping powder

Regulatory Information

Labeling: No hazard labeling required under GHS for laboratory amounts
Inventory Status: Registered under TSCA, REACH exemptions for research use
OSHA Status: Not considered hazardous under OSHA Hazard Communication Standard
SARA Status: Not a Section 313 listed substance
Other Regulations: Subject to standard rules for laboratory chemicals, local wastewater guidelines may apply for disposal