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Glucose Oxidase Material Safety Data Sheet (MSDS)

Identification

Product Name: Glucose Oxidase
Synonyms: β-D-glucose:oxygen 1-oxidoreductase
CAS Number: 9001-37-0
Recommended Uses: Laboratory reagent, food analysis, biotechnology applications, industrial enzymatic processing
Supplier Information: Manufacturer’s address, contact number, email
Emergency Phone: Emergency response hotline, available 24 hours
Molecular Formula: Enzyme, proteinaceous origin
Enzyme Classification: EC 1.1.3.4

Hazard Identification

GHS Classification: Not classified as hazardous under GHS standards
GHS Label Elements: No signal word or hazard pictogram required
Potential Hazards: Inhalation of enzyme dust may cause respiratory sensitization; may aggravate asthma upon repeated exposure; no skin or eye irritation reported for typical concentrations
Environmental Hazards: Not considered a significant environmental hazard at typical concentrations
NFPA Ratings: Health: 1, Flammability: 0, Reactivity: 0

Composition / Information on Ingredients

Chemical Name: Glucose Oxidase
Concentration: Activity dependent, usually supplied as lyophilized powder or aqueous solution
Enzyme Source: Aspergillus niger or Penicillium species
Additives: Stabilizers, preservatives (may include sodium chloride or buffer salts)
Impurities: Trace proteins, carbohydrates, fermentation byproducts

First Aid Measures

General Advice: Remove to fresh air, seek medical attention if symptoms persist
Inhalation: Move person to fresh air, provide oxygen if breathing is difficult, seek medical attention for persistent discomfort
Skin Contact: Rinse immediately with plenty of water and soap, remove contaminated clothing, medical attention if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, get medical attention for persistent irritation
Ingestion: Rinse mouth thoroughly, consult a physician or poison control for advice, no specific antidote
Important Symptoms: Allergic reactions in sensitized individuals, mild respiratory symptoms possible

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Specific Hazards from Fire: Combustion releases carbon oxides, nitrogen oxides, and possible traces of sulfur oxides
Protective Equipment: Firefighters should use self-contained breathing apparatus and protective clothing
Unusual Fire Hazards: Dust generation may present combustible dust explosion risk in poorly ventilated spaces
Advice for Firefighters: Avoid inhalation of combustion products, evacuate personnel to safe area

Accidental Release Measures

Personal Precautions: Use recommended personal protective equipment, avoid breathing dust
Environmental Precautions: Do not allow product to enter drains or watercourses; prevent spread of material using absorbent barriers
Cleanup Methods: Sweep or vacuum spill without generating dust, collect in suitable containers for disposal, ventilate the area
Disposal: Dispose of collected material in accordance with local environmental regulations
Incident Reporting: Notify responsible authorities if large quantities enter water or soil

Handling and Storage

Safe Handling: Minimize dust formation, avoid inhalation and contact with skin, wash hands after handling
Engineering Controls: Work in well-ventilated areas, use local exhaust ventilation if handling powder forms
Storage Conditions: Store tightly closed at 2–8°C, protect from excessive heat, humidity, and direct sunlight; store away from incompatible substances such as acids and oxidizers
Storage Life: Stable under recommended conditions, refer to manufacturer’s expiry date
Special Packaging Requirements: Airtight containers, secondary containment for bulk storage

Exposure Controls and Personal Protection

Exposure Limits: No published occupational exposure limits for Glucose Oxidase
Engineering Measures: Enclosed processes or local exhaust ventilation to control airborne concentrations
Personal Protective Equipment: Laboratory coat, chemical-resistant gloves (nitrile or latex), eye protection (safety glasses or goggles), face masks if dust is generated
Respiratory Protection: Approved particulate respirator (N95 or higher) if dust exposure possible
Hygiene Measures: Wash hands before breaks and at end of workday, avoid eating or drinking in processing areas

Physical and Chemical Properties

Appearance: Fine yellow to light brown powder or clear to pale yellow solution
Odor: Odorless or faint characteristic protein odor
pH: 4.0–7.0 for solutions, varies by buffer
Boiling Point: Not applicable (thermally degrades)
Melting Point: Not applicable for enzyme preparations
Solubility: Soluble in water, insoluble in organic solvents
Vapor Pressure: Not applicable (non-volatile)
Density: Typically 1.2–1.4 g/cm³ as powder
Flash Point: Not flammable in standard laboratory conditions
Partition Coefficient (n-octanol/water): Not determined (protein)
Decomposition Temperature: Degrades above 60°C

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: No hazardous reactions expected under normal use
Conditions to Avoid: High temperatures, strong acids and bases, strong oxidizers and reducing agents
Hazardous Decomposition Products: Thermal decomposition may yield carbon oxides, ammonia, and traces of nitrogen oxides
Polymerization: Does not occur
Incompatibility: Reacts with strong oxidizing compounds, strong acids

Toxicological Information

Acute Toxicity: Not acutely toxic by oral, dermal, or inhalation exposure in standard laboratory tests
Inhalation: Possible allergenic or asthmatic responses in susceptible individuals
Skin Contact: Low irritant potential; allergic contact dermatitis has been reported in enzyme-exposed workers
Eye Contact: May cause mild, reversible irritation
Chronic Exposure: Repeated inhalation may cause sensitization leading to occupational asthma
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA
Mutagenicity / Teratogenicity: Negative in in vitro and animal studies
Additional Notes: Enzyme allergy risk is well documented in industrial handling

Ecological Information

Ecotoxicity: No evidence of acute or chronic toxicity to aquatic organisms at concentrations used in industrial applications
Persistence and Degradability: Readily biodegradable; breaks down to amino acids and peptides in the environment
Bioaccumulative Potential: Not expected to bioaccumulate
Mobility in Soil: Low mobility due to binding to organic matter
Other Adverse Effects: Product not anticipated to cause long-term adverse environmental effects

Disposal Considerations

Disposal Methods: Dispose in accordance with local, regional, and national regulations; treat as non-hazardous industrial waste under most jurisdictions
Incineration: Suitable for enzyme-containing wastes where permissible
Recycling: Not applicable
Contaminated Packaging: Rinse, decontaminate, and dispose of packaging using approved procedures
Special Precautions: Avoid release in large quantities to sewage or watercourses

Transport Information

UN Number: Not regulated
Proper Shipping Name: Not subject to transport regulations
Transport Hazard Class: Non-hazardous
Packing Group: Not assigned
Special Transport Precautions: Prevent spillage during transfer; protect against physical damage to containers
Environmental Hazards: Not classified as marine pollutant or environmentally hazardous

Regulatory Information

Global Chemical Inventory Status: Listed in TSCA, EINECS, DSL, AICS, ENCS, other major inventories
GHS Classification: Not hazardous
Occupational Safety: No specific OSHA or ACGIH exposure limits; protection recommended where dust exposure likely
SARA Title III: Not listed as hazardous substance
Additional Regulations: Meets requirements for use in food, pharmaceutical, and laboratory settings under national and international laws
Labeling: Product labeling should include product name, hazard information, handling instructions, and emergency contacts