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Material Safety Data Sheet (MSDS) for Gamma Aminobutyric Acid (GABA)

Identification

Product Name: Gamma Aminobutyric Acid
Synonyms: 4-aminobutyric acid, GABA
Chemical Formula: C4H9NO2
CAS Number: 56-12-2
Recommended Use: Laboratory chemicals, research
Supplier Information: Chemical supplier address and emergency contact phone
Restrictions on Use: Non-food additive, not for personal use without supervision
Molecular Weight: 103.12 g/mol
Product Identifier: GABA Powder, Pharmaceutical/Laboratory Grade

Hazard Identification

GHS Classification: Not considered hazardous by GHS criteria
Label Elements: No symbol required for non-hazardous designation
Signal Word: None required
Hazard Statements: Not a hazardous substance or mixture under OSHA (29 CFR 1910.1200)
Precautionary Statements: Prevent contamination, avoid unnecessary exposure, keep container tightly closed, use proper protection
Potential Health Effects: May cause mild irritation if inhaled, ingested, or if contact with eyes/skin occurs; no known acute toxicity
Environmental Impact: No significant environmental hazards known under normal laboratory use
NFPA Ratings: Health: 0, Flammability: 0, Instability: 0

Composition / Information on Ingredients

Chemical Name: Gamma Aminobutyric Acid
Synonyms: 4-aminobutyric acid
CAS Number: 56-12-2
Concentration: 98-100% by weight
Impurities/Additives: None of regulatory concern
EC Number: 200-258-6
Classification: Not hazardous according to EU/US regulations

First Aid Measures

Inhalation: Move person to fresh air, monitor for respiratory issues; seek medical attention if symptoms persist
Skin Contact: Remove any contaminated clothing, wash affected skin with soap and water for a minimum of 15 minutes, seek medical advice if irritation persists
Eye Contact: Rinse thoroughly with water for at least 15 minutes, lift eyelids to ensure complete flushing; consult a physician if irritation or redness remains
Ingestion: Rinse mouth, drink water to dilute, never induce vomiting except under medical supervision, obtain medical attention if adverse effects occur
General Advice: Show this sheet to responders or medical personnel; ensure symptomatic and supportive care
Note for Physicians: Treat symptomatically, consider non-toxicological exposure

Fire-Fighting Measures

Suitable Extinguishing Media: Water, dry chemical powder, foam, CO2
Unsuitable Extinguishing Media: None identified; avoid excessive water runoff
Hazardous Combustion Products: Emits nitrogen oxides, carbon oxides under fire conditions
Firefighting Precautions: Wear self-contained breathing apparatus, chemical-resistant protective clothing
Special Hazards: Fine dust may form explosive mixture with air; standard facility precautions needed
Protective Actions: Move containers from fire area if safe; cool containers with water spray; control runoff to prevent contamination

Accidental Release Measures

Personal Precautions: Use appropriate PPE (gloves, goggles, mask), avoid dust formation, ventilate area
Evacuation Procedures: Isolate area, restrict unnecessary personnel access until cleaned
Environmental Precautions: Prevent entry to drains, sewers, or water sources, avoid large quantities releasing to surface waters
Spill Cleanup: Carefully collect powder mechanically or using an approved HEPA vacuum, place in a labeled disposal container, thoroughly wash spill area with water
Methods for Containment: Damp down to minimize dust; sweep or scoop into closed containers
Decontamination: Wash tools and exposed surfaces with soap and water

Handling and Storage

Handling: Use only with adequate ventilation, avoid generation of dust, wash hands after handling, prevent ingestion and inhalation, avoid skin and eye contact; wear lab coat, goggles, gloves
Storage Conditions: Store in tightly sealed original container, keep in a dry, cool, well-ventilated environment, away from incompatible substances (strong oxidizers)
Storage Incompatibilities: Avoid direct sunlight, high humidity, and substances that could cause decomposition
Container Requirements: Use containers made of compatible material, label properly, keep away from food and drink

Exposure Controls and Personal Protection

Occupational Exposure Limits: No specific regulatory limits set for GABA
Engineering Controls: Use local exhaust or general dilution ventilation to manage dust
Personal Protective Equipment (PPE): Protective gloves (nitrile, latex), safety goggles, lab coat; for respiratory protection, use NIOSH-approved dust mask or respirator if handling large quantities
Hygiene Measures: Wash hands before breaks and after finishing work, avoid eating or drinking in the lab, remove and clean contaminated clothing before reuse
Environmental Controls: Avoid releases to environment, ensure proper air filtering in workspace

Physical and Chemical Properties

Appearance: White crystalline powder
Odor: Odorless or slight characteristic odor
Odor Threshold: Not available
pH: 7.3 (10g/L H2O, 20°C)
Melting Point/Range: 203 – 205°C
Boiling Point: Decomposes
Flash Point: Not applicable
Evaporation Rate: Not applicable
Upper/Lower Flammability Limits: Not established
Vapor Pressure: Negligible at room temperature
Vapor Density: Not available
Relative Density: 1.192 g/cm3 (20°C)
Solubility: Soluble in water (130 g/L at 25°C), insoluble in ethanol, ether, benzene
Partition Coefficient: log Pow = -3.2
Auto-Ignition Temperature: No data
Decomposition Temperature: >203°C
Viscosity: Not applicable

Stability and Reactivity

Chemical Stability: Stable under recommended handling and storage conditions
Reactivity: Does not react dangerously with water or most laboratory reagents
Possibility of Hazardous Reactions: Not likely under normal use
Conditions to Avoid: Moisture, high temperature, direct sunlight
Incompatible Materials: Strong oxidizers, strong acids
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide

Toxicological Information

Acute Toxicity: Low toxicity based on available data; oral LD50 (rat): >5050 mg/kg
Skin Corrosion/Irritation: Not a primary irritant
Eye Damage/Irritation: Dust may irritate eyes, no documented severe injury
Respiratory Sensitization: Not classified as a respiratory sensitizer
Skin Sensitization: No evidence found for skin sensitization
Germ Cell Mutagenicity: Not mutagenic in standard tests
Carcinogenicity: Not listed as carcinogen by IARC, NTP, ACGIH, OSHA
Reproductive Toxicity: No effects observed in standard animal studies
Repeated Dose Toxicity: No target organ toxicity observed
Potential Health Effects: Mild irritation for those with high sensitivity, otherwise considered safe at typical exposure levels

Ecological Information

Toxicity to Aquatic Life: No ecotoxicological data indicating significant hazard
Persistence and Degradability: Readily biodegradable under typical environmental conditions
Bioaccumulation: Low potential for bioaccumulation (log Pow = -3.2)
Mobility in Soil: High water solubility, likely to partition into water phase, limited adsorption to soil
Other Adverse Effects: No known effects on ozone layer or global warming; not a known marine pollutant
Precautions: Avoid uncontrolled release into environment, manage lab waste responsibly

Disposal Considerations

Waste Treatment Methods: Small amounts can go in laboratory chemical waste, in accordance with local regulations
Product Disposal: Dissolve in water and dispose via sanitary sewer if permitted, otherwise use licensed waste disposal contractors
Contaminated Packaging: Triple rinse containers, offer for recycling or disposal as permitted, make sure residues do not contaminate
Special Precautions: Do not dispose with household waste, avoid release to surface water

Transport Information

UN Number: Not assigned, not a regulated chemical by transport agencies
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not classified
Packing Group: Not applicable
Marine Pollutant: No
Special Precautions: Ensure packaging prevents dust release, normal shipment protocols for non-hazardous research chemicals
Transport Labels: None required

Regulatory Information

OSHA: Compliant, not a hazardous substance under OSHA Hazard Communication Standard
TSCA: Listed
REACH Registration: Exempt as naturally occurring
SARA 302/304/313: Not listed
California Proposition 65: Not subject to warning requirements
WHMIS (Canada): Not controlled
Other Standards: Not listed as a dangerous substance on global regulatory frameworks
Labeling Requirements: Standard laboratory chemical labeling only