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Material Safety Data Sheet for Folic Acid

Identification

Product Name: Folic Acid
Chemical Name: Pteroylglutamic acid
Synonyms: Vitamin B9, Folate, FA
CAS Number: 59-30-3
Recommended Use: Nutritional supplement, food fortification, research reagent
Manufacturer: Contact manufacturer or supplier listed on the label
Emergency Contact: Local poison control center, nearby health and safety authority

Hazard Identification

Classification: Not classified as hazardous according to OSHA Hazard Communication Standard, slight dust irritation possible
Signal Word: None required
Hazard Statements: May cause mild eye and respiratory irritation in sensitive individuals
Pictograms: Not required
Precautionary Statements: Avoid breathing dust, minimize contact with eyes and skin
Routes of Exposure: Inhalation, eye and skin contact, ingestion

Composition / Information on Ingredients

Chemical Identity: Folic Acid
Purity: 95-100%
Physical Form: Yellow to orange crystalline powder
Impurities: May contain trace related substances depending on source

First Aid Measures

Inhalation: Move to fresh air, seek medical attention if symptoms persist
Eye Contact: Rinse carefully with plenty of water for several minutes, remove contacts if present and easy to do, seek advice if irritation continues
Skin Contact: Wash thoroughly with mild soap and water, remove contaminated clothing
Ingestion: Rinse mouth, give water to dilute if conscious, do not induce vomiting, seek medical attention if significant quantity consumed or symptoms develop
Most important symptoms: Mild respiratory, skin, or eye irritation

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide
Unsuitable Extinguishing Media: Strong water jet may spread dust
Specific Hazards: Emits toxic fumes of nitrogen oxides and carbon oxides when burned
Special Equipment for Firefighters: Wear self-contained breathing apparatus, protective clothing
Further Information: Avoid inhalation of combustion gases, control runoff to prevent environmental contamination

Accidental Release Measures

Personal Precautions: Avoid dust generation, use personal protection as outlined below
Environmental Precautions: Prevent entry into drains, waterways, or soil
Methods for Cleaning Up: Sweep or vacuum up material, place in a suitable container for disposal, avoid raising dust, ventilate area
Reference to Other Sections: Refer to exposure controls and personal protection section before cleanup

Handling and Storage

Handling: Minimize dust, handle with dry hands, avoid contact with eyes and skin, use adequate ventilation
Storage: Store in tightly closed container, keep in a dry, cool, and well-ventilated area away from incompatible substances such as strong oxidizing agents and acids, protect from light and moisture
Incompatibilities: Strong acids, strong oxidizers

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established exposure limit for folic acid
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to limit airborne dust
Personal Protective Equipment:

  • Respiratory Protection: NIOSH-approved dust respirator if dust levels exceed occupational exposure limits
  • Eye Protection: Safety goggles or face shield
  • Skin Protection: Gloves, lab coat
  • Hygiene Measures: Wash hands thoroughly after handling, do not eat or drink in work area

Physical and Chemical Properties

Appearance: Yellow to orange crystalline powder
Odor: Practically odorless
Odor Threshold: Not established
pH: Slightly acidic in solution
Melting Point: Decomposes above 250°C
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Not considered flammable
Vapor Pressure: Not available
Solubility: Slightly soluble in water, more soluble in alkaline solutions
Partition Coefficient (log Kow): Not available
Vapor Density: Not available
Relative Density: 1.68 g/cm3
Auto-ignition Temperature: Not available
Decomposition Temperature: Above 250°C
Viscosity: Not applicable

Stability and Reactivity

Chemical Stability: Stable under recommended handling and storage conditions
Hazardous Reactions: No known hazardous polymerization
Conditions to Avoid: Exposure to heat, moisture, light, incompatible materials
Incompatible Materials: Strong oxidizing agents, strong acids
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides upon combustion or decomposition

Toxicological Information

Acute Toxicity: Low toxicity; oral LD50 in rats >10,000 mg/kg
Skin Corrosion/Irritation: Not a skin irritant under normal handling, prolonged contact may cause mild irritation
Eye Damage/Irritation: Mild transient irritation
Respiratory Sensitization: Dust may cause mild irritation to upper respiratory tract
Skin Sensitization: Not regarded as a skin sensitizer
Carcinogenicity: Not listed as a carcinogen by NTP, IARC, OSHA
Reproductive Toxicity: High doses affect fetal development; vital nutrient for prenatal health at recommended intake
STOT – Single Exposure: Not expected at occupational exposure
STOT – Repeated Exposure: No long-term toxicity at nutritional doses
Aspiration Hazard: Not classified as an aspiration hazard

Ecological Information

Ecotoxicity: Not regarded as hazardous to aquatic or terrestrial environments at expected concentrations
Persistence and Degradability: Rapidly biodegradable under natural environmental conditions
Bioaccumulative Potential: Not expected to bioaccumulate
Mobility in Soil: Water soluble forms may leach into subsoil, low environmental persistence
Other Adverse Effects: None known at typical discharge levels

Disposal Considerations

Product Disposal: Dispose of in accordance with local, regional, and national regulations; small quantities may be washed away with plenty of water; large quantities require licensed chemical waste disposal
Contaminated Packaging: Empty containers should be rinsed thoroughly and offered for recycling or disposal following regulations
Special Precautions: Do not release large amounts to environment; prevent entry into waterways

Transport Information

UN Number: Not assigned
UN Proper Shipping Name: Not regulated for transport
Transport Hazard Class(es): None
Packing Group: None
Environmental Hazards: Not classified as marine pollutant
Special Precautions for User: Protect packaging from moisture and mechanical damage during transport

Regulatory Information

US Federal Regulations: Not listed under CERCLA, SARA, or TSCA for specific regulation; general workplace safety rules apply
OSHA Status: Not hazardous as defined by OSHA standards
California Proposition 65: Not listed
EU Regulations: Not defined as hazardous according to Regulation (EC) No 1272/2008 (CLP)
Other International Inventories: Present on DSL, EINECS, AICS
Label Elements: No specific hazard labeling required for folic acid