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Product Name: Flubendazole
Chemical Formula: C16H12FN3O3
CAS Number: 31430-15-6
Supplier Details: Manufacturer information available on packaging, contact details and emergency contact provided on original container.
Recommended Use: Anthelmintic compound used in veterinary applications.
Synonyms: Flubenol; methyl N-(6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl)carbamate
Restrictions on Use: Use strictly in accordance with industry and regulatory standards for veterinary pharmaceuticals.
Classification: Classified as hazardous under GHS for acute toxicity (oral, inhalation, dermal), specific target organ toxicity, and environmental hazards.
Pictogram: Exclamation mark, health hazard, aquatic environment.
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes eye and skin irritation, suspected of causing genetic defects, toxic to aquatic life with long lasting effects.
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, use personal protective equipment, avoid release to environment, collect spillage.
Active Substance: Flubendazole
Chemical Identifier: CAS: 31430-15-6
Concentration: 98–100%
Impurities: Trace quantities of related benzimidazole derivatives (less than 1%)
Formulation Additives: None in pure substance; excipients may be present in commercial formulations.
Inhalation: Move exposed person to fresh air, monitor for respiratory issues, seek medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing, wash affected skin thoroughly with soap and water, seek medical advice if irritation develops.
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, consult a physician if irritation persists.
Ingestion: Rinse mouth, do not induce vomiting, give water if conscious, seek medical attention without delay.
Note for Medical Professionals: Treat symptomatically; no specific antidote documented.
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide.
Specific Hazards: Product may emit toxic fumes including carbon oxides, nitrogen oxides, hydrogen fluoride during combustion.
Protective Equipment for Firefighters: Use self-contained breathing apparatus and full protective clothing.
Special Procedures: Prevent firewater run-off from contaminating groundwater and surface water systems.
Personal Precautions: Wear protective gear: gloves, goggles, dust mask. Avoid breathing dust, avoid direct contact with skin and eyes.
Environmental Precautions: Prevent spillage from entering waterways, drains, or sewers; hazardous to aquatic life.
Cleanup Methods: Collect spillage using dry means (shovel or broom), place in labeled containers, ventilate area, wash site with water after cleaning.
Disposal: Dispose of contaminated materials following legal regulations for hazardous waste.
Safe Handling: Work in well-ventilated spaces, avoid dust formation, do not eat, drink, or smoke during use, use only with recommended PPE.
Storage Conditions: Keep container tightly closed, store in a cool, dry, well-ventilated area, protect from heat, sunlight, and moisture.
Incompatible Materials: Strong acids, bases, oxidizers.
Packaging Material: Use original manufacturer-approved containers, keep containers upright.
Exposure Limits: No official occupational exposure limits assigned at most jurisdictions; minimize airborne concentrations.
Engineering Controls: Local exhaust ventilation, enclosed processes where possible.
Personal Protective Equipment: Gloves (nitrile recommended), chemical safety goggles, lab coat or chemical-resistant coverall, dust mask or NIOSH-approved respirator for significant airborne exposure.
Hygiene Measures: Wash hands and face after handling, remove contaminated clothing promptly, routine laundering of work clothing.
Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 205–210°C
Boiling Point: Not established (decomposes before boiling)
Solubility: Practically insoluble in water; soluble in DMSO, dimethylformamide, slightly soluble in acetone
pH: Not applicable (non-aqueous)
Vapor Pressure: Negligible at ambient temperatures
Partition Coefficient (Log Pow): Estimated 2.91
Stability: Stable under normal conditions, photosensitive
Decomposition Temperature: Above 210°C
Reactivity: No hazardous reactivity expected under normal conditions.
Chemical Stability: Stable in dry, dark storage conditions.
Possibility of Hazardous Reactions: No dangerous reactions known under intended use.
Conditions to Avoid: Strong light, elevated temperatures, moisture, incompatible substances.
Incompatible Materials: Strong oxidizers, acids, alkalis.
Hazardous Decomposition Products: Toxic fumes (carbon oxides, nitrogen oxides, hydrogen fluoride) on thermal decomposition.
Acute Oral Toxicity: Harmful if swallowed; LD50 (rat): ~1000–2000 mg/kg
Acute Dermal Toxicity: May cause irritation; no severe toxicity reported.
Inhalation Toxicity: Dust may cause respiratory irritation.
Skin Corrosion/Irritation: Possible mild irritation on contact.
Eye Damage/Irritation: Potential irritant, not corrosive.
Chronic Exposure: Potential mutagenic/teratogenic effects observed in animal studies.
Sensitization: No confirmed reports of sensitization in humans.
Other Effects: May depress hematopoietic system in high, chronic exposures.
Ecotoxicity: Highly toxic to aquatic organisms; long term adverse effects likely in aquatic environments, LC50 (fish): <1 mg/L.
Persistence and Degradability: Slowly biodegradable, stable in the environment.
Bioaccumulation Potential: Moderate; log Pow suggests potential for bioaccumulation in aquatic organisms.
Mobility in Soil: Low mobility due to poor solubility in water.
Other Adverse Effects: Not identified for terrestrial organisms, risk primarily for aquatic life.
Disposal Methods: Incinerate in approved facility or landfill at permitted sites according to local, state, and federal regulations.
Packaging Disposal: Rinse and triple-wash containers, puncture, dispose at controlled sites.
Avoid: Release to surface waters, open-air burning, sewer disposal.
UN Number: UN3077 (if shipped as environmentally hazardous substance, solid, n.o.s.)
UN Proper Shipping Name: Environmentally hazardous substance, solid, n.o.s. (contains Flubendazole)
Transport Hazard Class: Class 9 – Miscellaneous dangerous substances
Packing Group: III (minor danger)
Environmental Hazards: Marine pollutant
Special Precautions for User: Avoid spillage during loading/unloading, secure packaging, placard as hazardous if required.
Labelling per GHS: Hazard symbols, signal words, and precautionary statements apply; review local implementation.
Inventory Listing: Included in EU REACH, US TSCA, Australia AICS, and similar chemical inventories.
Restrictions: Veterinary use only; not registered for use in food animals in all jurisdictions.
Worker Safety: Covered by occupational health and chemical safety laws.
Environmental Regulations: Strict controls on aquatic release, waste disposal, and contamination risks.
