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Product Name: Florfenicol
Chemical Name: 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
Chemical Formula: C12H14Cl2FNO4S
Other Name: Florfenicolum
CAS Number: 73231-34-2
Recommended Use: Veterinary antimicrobial
Manufacturer: Chemical manufacturers and veterinary pharmaceutical companies
Emergency Contact: Local poison control or chemical emergency hotline numbers
GHS Classification: Skin sensitization Category 1, Eye irritation Category 2A, Reproductive toxicity Category 2
Signal Word: Warning
Hazard Statements: May be harmful if swallowed or inhaled. Causes serious eye irritation. May cause allergic skin reaction. Suspected of damaging fertility or the unborn child.
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust or vapors. Use only outdoors or in a well-ventilated area. Wear eye protection, gloves, and protective clothing. Avoid contact with skin and eyes. Wash hands thoroughly after handling.
Substance: Florfenicol
Chemical Name: Florfenicol
CAS Number: 73231-34-2
Concentration: 98-100%
Impurities: May contain trace amounts of organic solvents and degradation products
Inhalation: Move affected person to fresh air. Use artificial respiration if the person is not breathing. Seek medical attention for any breathing difficulties.
Skin Contact: Remove contaminated clothing. Wash skin thoroughly with soap and water. Seek medical advice if irritation develops or persists.
Eye Contact: Rinse eyes cautiously with water for at least fifteen minutes. Remove contact lenses if present and easy to do. Get medical help immediately.
Ingestion: Rinse mouth with water. Do not induce vomiting unless advised by a doctor. Seek immediate medical attention.
Most Important Symptoms: Allergic reactions, irritation, respiratory discomfort, potential reproductive effects
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray
Specific Hazards: May emit toxic fumes such as hydrochloric acid, sulfur oxides, nitrogen oxides upon combustion
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing
Advice for Firefighters: Prevent contaminated water from entering drains or watercourses. Approach fire from upwind to avoid hazardous vapors.
Personal Precautions: Keep unprotected people away. Provide adequate ventilation. Wear protective equipment including gloves, respiratory protection, and goggles.
Environmental Precautions: Avoid release to the environment. Do not allow product or residue to enter drains, sewers, or watercourses.
Methods for Clean-Up: Collect solid material using damp cloth or absorbent material. Place in closed, labeled container for proper disposal. Wash spill area thoroughly with water and detergent.
Precautions for Safe Handling: Handle in a well-ventilated place. Avoid dust formation and contact with skin or eyes. Do not eat, drink, or smoke when working with this material.
Conditions for Safe Storage: Store in tightly closed containers. Keep in a cool, dry, well-ventilated area away from incompatible substances such as strong acids and bases. Protect from light and moisture. Maintain temperature between 15 and 25°C.
Engineering Controls: Use local exhaust ventilation to control dust exposure. Ensure eye wash stations and safety showers are available near work area.
Personal Protective Equipment: Wear chemical-resistant gloves, protective clothing, and safety goggles. Use high-efficiency respirator if airborne dust or vapors are present.
Occupational Exposure Limits: No specific limits published; minimize exposure as a prudent measure.
Hygiene Measures: Wash hands, forearms, and face thoroughly after handling. Remove contaminated clothing and wash before reuse.
Appearance: White crystalline powder
Odor: Odorless
Melting Point: 153–155°C
Solubility in Water: Slightly soluble
pH: 4.5–5.5 (1% solution)
Boiling Point: Not applicable (decomposes)
Flash Point: Not available
Vapor Pressure: Negligible
Density: Approximately 1.53 g/cm³
Partition Coefficient (Log Pow): 0.48
Chemical Stability: Stable under normal storage and handling conditions
Conditions to Avoid: Excessive heat, moisture, exposure to strong light
Incompatible Materials: Strong acids, strong bases, strong oxidizing agents
Hazardous Decomposition Products: Hydrogen chloride, sulfur oxides, nitrogen oxides, carbon oxides
Possibility of Hazardous Reactions: Not likely under proper storage and handling
Acute Toxicity: Low acute toxicity by oral, dermal, and inhalation exposure
Skin Sensitization: May cause allergic skin reaction
Eye Effects: Causes serious eye irritation
Chronic Effects: Animal studies suggest reproductive toxicity and effects on fertility at high doses
Mutagenicity: Not identified as mutagenic in standard tests
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA
Target Organs: Liver, kidneys, reproductive organs based on high-dose animal studies
Aquatic Toxicity: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Moderately persistent in soil and water
Bioaccumulative Potential: Low bioaccumulation expected based on Log Pow
Mobility in Soil: Moderate, depends on soil type
Other Adverse Effects: Antibiotic residues may disrupt microbial communities in soil and water ecosystems
Waste Treatment Methods: Dispose of as hazardous waste according to local, regional, national, and international regulations.
Contaminated Packaging: Rinse containers thoroughly and dispose of in accordance with relevant regulations
Environmental Precautions: Do not discharge unused material or contaminated water to drains, sewers, or water bodies
UN Number: Not regulated as hazardous for transport under UN, DOT, IATA, or IMDG codes
Proper Shipping Name: Florfenicol
Transport Hazard Class: Not classified
Packing Group: Not applicable
Special Precautions: Avoid extreme temperatures. Ensure containers are undamaged, properly sealed, and labeled during transport.
Regulatory Status: Approved for veterinary use in many jurisdictions. Not registered for human pharmaceutical use.
Labeling Requirements: Subject to requirements for veterinary drugs and hazardous chemicals in jurisdiction of sale and use
OSHA Status: Not listed as a hazardous substance under OSHA Hazard Communication Standard
SARA/Title III: Not listed as extremely hazardous substance
Other Regulations: Subject to environmental release reporting, workplace safety measures, and veterinary prescription rules as set by relevant authority. Review national and regional legislation for additional requirements.
