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Material Safety Data Sheet for Ethyl-p-hydroxybenzoate

Identification

Product Name: Ethyl-p-hydroxybenzoate
Synonyms: Ethylparaben, 4-Hydroxybenzoic acid ethyl ester
Chemical Formula: C9H10O3
CAS Number: 120-47-8
Molecular Weight: 166.17 g/mol
Recommended use: Preservative in cosmetics and pharmaceuticals
Supplier Contact: Refer to manufacturer details on packaging
Emergency Contact: Local poison control centers, national emergency numbers

Hazard Identification

Classification: Not classified as hazardous by GHS criteria
Health Hazards: May cause mild skin and eye irritation, rare allergic reactions
Environmental Hazards: Not considered hazardous for the environment in small quantities, large spills can threaten aquatic life
Physical Hazards: Fine powder can cause dust, increasing risk of inhalation
Pictograms: No pictograms required by GHS
Signal Word: None required
Precautionary Statements: Avoid generating dust, use in well-ventilated areas, handle with care

Composition / Information on Ingredients

Chemical Name: Ethyl-p-hydroxybenzoate
Common Name: Ethylparaben
Purity: ≥99%
Impurities: Trace related esters (methylparaben, propylparaben possible in mixtures)
Additives: None expected

First Aid Measures

Inhalation: Remove person to fresh air, seek medical help if symptoms persist, monitor for respiratory irritation
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, seek medical advice for persistent redness
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes, hold eyelids open, seek medical attention if irritation continues
Ingestion: Rinse mouth, do not induce vomiting, seek medical attention if feeling unwell, provide water if conscious
Most Important Symptoms/Effects: Mild irritation, allergic skin reactions in rare cases

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Media: Strong water jets may spread powder form
Specific Hazards: Combustion releases smoke, carbon oxides
Protective Equipment: Firefighters wear self-contained breathing apparatus and protective clothing
Special Procedures: Remove containers from fire area, cool with water spray if safe, prevent runoff into drains

Accidental Release Measures

Personal Precautions: Wear gloves, protective eyewear, dust mask, avoid direct contact
Environmental Precautions: Prevent entry into drains, sewers, and waterways, contain spill
Cleanup Methods: Sweep up, avoid dust generation, collect into containers for disposal, wash spill area with water
Emergency Procedures: Evacuate unnecessary personnel, ventilate area, monitor for air quality

Handling and Storage

Safe Handling: Avoid dust formation, use local ventilation, wash hands after use, keep away from food and drinks
Storage Conditions: Store in sealed, labeled containers, keep in cool, dry, ventilated space, protect from moisture and strong light
Incompatible Materials: Strong oxidizers, strong acids, strong bases
Safe Transfer: Use non-sparking tools, ground/bond containers

Exposure Controls and Personal Protection

Engineering Controls: Local exhaust ventilation, closed systems for industrial use
Occupational Exposure Limits: No established OSHA, ACGIH, NIOSH limits
Respiratory Protection: Dust mask or respirator for dust-producing operations
Hand Protection: Chemical-resistant gloves, preferably nitrile or latex
Eye Protection: Safety goggles with side shields
Skin/Body Protection: Long-sleeved clothing, lab coat
Hygiene Measures: Wash after handling, remove contaminated clothing

Physical and Chemical Properties

Appearance: White crystalline powder
Odor: Faint, characteristic
pH: Slightly acidic to neutral (in 1% water solution)
Melting Point: 115-118°C
Boiling Point: Not applicable (decomposes)
Flash Point: 250°C (closed cup)
Explosive Properties: Not explosive
Solubility: Slightly soluble in water, freely soluble in alcohol and ether
Partition Coefficient (log Kow): About 2.5
Vapor Pressure: Negligible at room temperature
Density: 1.3 g/cm³

Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures
Thermal Decomposition: Produces carbon oxides at high temperatures
Possibility of Hazardous Reactions: None reported in standard use
Incompatible Materials: Strong oxidizing agents, strong acids and bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, minor organics

Toxicological Information

Acute Toxicity (Oral, Rat): LD50 > 2,000 mg/kg
Skin Irritation: Mild, not a significant irritant
Eye Irritation: Possible mild irritation
Carcinogenicity: No evidence in animal or human data
Mutagenicity: Negative in standard tests
Reproductive Toxicity: No known effects
Sensitization: Rare, isolated allergic responses
Chronic Effects: Not documented at anticipated exposures

Ecological Information

Toxicity to Aquatic Life: Low toxicity at usual environmental concentrations, can affect aquatic organisms in large releases
Bioaccumulation Potential: Low to moderate (log Kow 2.5)
Environmental Fate: Biodegradable, breaks down under environmental conditions, limited persistence
Mobility in Soil: Moderate, may leach with water

Disposal Considerations

Disposal Methods: Dispose as non-hazardous chemical waste unless local regulations require special treatment
Container Disposal: Triple-rinse and recycle or land-fill if permitted
Precautions: Do not release large quantities into waterways or open environments, avoid dust generation during disposal
Regulatory Waste Codes: Check local, regional, and national waste handling requirements

Transport Information

UN Number: Not classified as dangerous goods
Proper Shipping Name: Pariwise with product identifier
Transport Hazard Classes: Not regulated
Packing Group: Not assigned
Special Transport Precautions: Avoid shipping with incompatible materials, use dry condition packaging to prevent caking and material degradation

Regulatory Information

Labeling Requirements: In accordance with local regulations for pharmaceuticals and food additives
Risk Phrases: Not classified under major risk labeling schemes
SARA 313: Not listed
TSCA: Listed
REACH Status: Registered for listed uses in the EU
Inventory Listings: Included in main global chemical inventories (US TSCA, EINECS, DSL, AICS)
Restriction: Some countries set maximum limits for use in cosmetics and foods