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Product Name: Erythrosine
Other Names: FD&C Red No.3, Acid Red 51, E127
Chemical Formula: C20H6I4Na2O5
CAS Number: 16423-68-0
Recommended Use: Synthetic food dye, laboratory reagent
Manufacturers: Sourced from leading chemical suppliers involved in food-grade and research pigment distribution
Contact Information: Emergency phone number and technical support listed on product packaging
Hazard Classification: Classified under Eye Irritant Category 2A; possible skin and respiratory irritant
Signal Word: Warning
Hazard Statements: Causes eye irritation, may trigger allergic skin reaction after frequent or prolonged contact, dust inhalation can lead to respiratory tract irritation
Pictograms: Exclamation mark (irritant)
Precautionary Statements: Avoid breathing dust, wash skin thoroughly after handling, use in a well-ventilated area or outdoors
Other information: Chronic exposure in animal studies has shown thyroid effects, so keeping dust exposure low matters
Chemical Name: Disodium 2,4,5,7-tetraiodofluorescein
Purity: ≥85% Erythrosine
Other Components: Unreacted feedstock, inorganic salts (mainly sodium chloride and sodium sulfate in trace)
Impurities: Minimal, not expected to pose hazard under normal use
Inhalation: Move person to fresh air, keep at rest comfortably; seek medical help for breathing difficulty
Skin Contact: Immediately wash skin with soap and water, remove contaminated clothing, seek advice for irritation
Eye Contact: Rinse with plenty of water for at least ten minutes, lifting eyelids to fully flush, medical evaluation for persistent discomfort
Ingestion: Rinse mouth, drink water (if conscious), call physician if symptoms arise
Most Important Symptoms: Redness, tearing, respiratory discomfort; high levels may lead to headache or nausea
Advice for Medical Professionals: Supportive care, symptom monitoring, treat exposure as chemical irritant
Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical powder, or carbon dioxide; avoid direct water jets
Fire Hazards: Thermal decomposition produces toxic or irritating fumes of iodine compounds, carbon oxides, sodium compounds
Protective Equipment: Full protective suit and self-contained breathing apparatus required for fire situations
Specific Methods: Prevent run-off from entering drains or waterways; control dust formation
Personal Precautions: Wear eye protection, gloves, respirator if airborne dust present
Environmental Precautions: Prevent entry into sewers, surface and ground waters
Clean-up Methods: Sweep up, collect in containers for safe disposal; avoid raising dust
Decontamination: Wash area with soap and water after clean-up, ventilate space
Waste Handling: Do not mix with incompatible materials; dispose safely using local hazardous waste facilities
Precautions for Safe Handling: Handle using gloves and eye protection, avoid creating dust clouds, ensure local exhaust or general ventilation
Avoid Contact With: Eyes, skin, clothing; incompatible substances like strong oxidizers and reducing agents
Storage Conditions: Store in tightly closed, labeled containers in a cool, dry, well-ventilated area, separate from food and animal feed
Safe Transferring: Use dust extraction equipment, do not eat, drink, or smoke when working with dye powders
Occupational Exposure Limits: No established OSHA or ACGIH limits for Erythrosine; minimize dust to airborne nuisance levels (total inhalable dust typically kept below 10 mg/m³)
Engineering Controls: Provide local exhaust ventilation, eyewash stations, suitable safety showers
Personal Protective Equipment: Wear chemical safety goggles, dust mask or respirator, gloves (nitrile or PVC), lab coat or coveralls
Hygienic Measures: Wash hands after handling, keep work area clean, remove contaminated clothing promptly
Appearance: Dark red to reddish-brown crystalline powder
Odor: Odorless
pH (1% solution): 7.0–8.0
Melting Point: Not clearly defined (decomposes above 300°C)
Solubility: Freely soluble in water, slightly soluble in alcohol, insoluble in ether
Flash Point: Not flammable
Relative Density: Around 2.2–2.3 g/cm³
Partition Coefficient: Log Kow estimated at -2.2 (low potential for bioaccumulation)
Decomposition Temperature: Above 300°C with release of toxic fumes
Stability: Stable under recommended storage and normal handling conditions
Reactive Hazards: May react with strong reducing agents, avoid strong oxidizers and extreme heat
Conditions to Avoid: Exposure to high temperatures, sources of ignition, accidental mixing with incompatible substances
Decomposition Products: Iodine vapors, carbon oxides, sodium compounds, trace toxic gases possible
Acute Toxicity: Low toxicity by oral, dermal, and inhalation exposure in laboratory animals; LD50 oral (rat) > 2,000 mg/kg
Skin Corrosion/Irritation: May cause mild to moderate irritation upon prolonged or repeated exposure
Eye Damage/Irritation: Causes irritation with redness, watering, discomfort
Respiratory Effects: Dust may be irritating to mucous membranes and upper respiratory tract
Sensitization: Skin sensitization observed in rare cases
Carcinogenicity: Classified by IARC as not classifiable as to carcinogenicity to humans (Group 3); rodent studies showed increased incidence of thyroid tumors with chronic high doses
Other Chronic Effects: Long-term animal studies indicate thyroid hormone disturbances at high doses
Ecotoxicity: Low toxicity to aquatic organisms; not expected to bioaccumulate based on physicochemical properties
Persistence/Degradability: Degrades slowly in soil and water, but photodegradation occurs in sunlight
Mobility: Highly soluble in water, can travel through aquatic environments; avoid release to waterways
Bioaccumulation: Unlikely due to low octanol-water partition coefficient
Aquatic Effects: Large spills may cause discoloration of water and temporary disturbance to algae or bacteria populations
Disposal Methods: Dispose of in accordance with local, regional, and national regulations for colored chemicals or dyes
Incineration: Acceptable in approved, controlled facilities to prevent environmental exposure
Container Disposal: Rinse packaging thoroughly, offer for recycling or dispose as hazardous laboratory waste
Special Precautions: Do not discharge to natural water sources, municipal sewers, or general waste streams
UN Number: Not regulated as a hazardous material for transport by most global authorities
Transport Hazard Class: Not classified as dangerous goods
Packing Group: Not applicable
Proper Shipping Name: Erythrosine or Disodium erythrosin
Transport Precautions: Keep containers sealed and upright during shipment; avoid breakage and spillage
Regulation Status: Approved for use as a food additive in several countries with concentration limits; US FDA lists as food colorant E127, under CFR Title 21
Workplace Rules: Covered by chemical hygiene, hazard communication, and laboratory safety standards
REACH/CLP (EU): Registered substance with specific use and hazard restrictions
TSCA (US): Listed in Toxic Substances Control Act inventory
Other Listings: Check regional health, environmental, and transport authority guidelines for any additional handling instructions
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
