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Substance Name: Epigallocatechin Gallate
Synonyms: EGCG, (–)-Epigallocatechin-3-gallate
Chemical Formula: C22H18O11
Molecular Weight: 458.37 g/mol
CAS Number: 989-51-5
Recommended Use: Antioxidant ingredient in supplements, food additives, cosmetic formulations, research applications
Manufacturer/Supplier: Information available from product provider
Emergency Contact: Refer to national poison center or emergency local services
Classification: Not classified as hazardous under GHS criteria
Label Elements: No pictogram, signal word not required
Route of Entry: Inhalation, ingestion, skin and eye contact
Potential Health Effects: May cause mild irritation to eyes, skin, or respiratory tract; ingestion of large amounts can cause stomach upset, headache, or rare hypersensitivity
Environmental Hazards: No proven acute aquatic toxicity, but persistent large-scale release may disturb local biota
Chemical Identity: Epigallocatechin Gallate
Purity: >98% as supplied by typical bulk manufacturers
Impurities: Traces of other catechins or natural tannins possible
Additives: None, unless specified on product label
Inhalation: Move to fresh air; medical help if symptoms persist
Skin Contact: Wash area thoroughly with soap and water, remove contaminated clothing
Eye Contact: Rinse carefully under running water for at least 15 minutes; seek medical attention if irritation continues
Ingestion: Rinse mouth, drink water, do not induce vomiting; get medical advice if feeling unwell
Advice for Emergency Responders: No special protective gear required for small exposures; standard workplace hygiene applies
Flammability: EGCG powder can burn if involved in a fire, fine dust may form explosive mixtures in air
Suitable Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide
Unsuitable Media: Avoid high-pressure water streams that may spread dust
Hazards from Combustion: Carbon oxides and minor organic volatiles possible
Special Protective Actions: Wear standard firefighting gear including self-contained breathing apparatus if dense smoke
Explosion Sensitivity: Avoid accumulation of airborne dust—keep work area clean and well ventilated
Personal Precautions: Avoid breathing dust, use protective gloves and eyewear
Spill Cleanup: Sweep up carefully to avoid dusting, collect in labeled container for disposal
Environmental Precautions: Prevent large quantities from reaching drains, surface water, or soil
Methods for Containment: Dampen powder slightly to reduce dust if necessary, ventilate area
Reference to Other Sections: Refer to disposal and exposure controls for further guidance
Safe Handling: Minimize dust generation, wash hands after use, avoid contacting eyes and mouth
Storage Conditions: Keep tightly sealed, dry, cool, and away from direct sunlight; store in original container
Incompatibilities: Strong oxidizers, moisture, direct UV exposure
Specific Uses: Research, food, and pharma stages as supplied; check purity for sensitive processes
Occupational Exposure Limits: No specific exposure limits set for EGCG
Engineering Controls: Local exhaust ventilation or use of fume hoods
Personal Protective Equipment: Wear protective gloves, laboratory coat, safety glasses or goggles; mask recommended for handling large quantities
Respiratory Protection: Use NIOSH-approved dust mask if dusting occurs
Environmental Controls: Prevent release to open environment; keep worksite clean
Appearance: Fine greenish or yellowish powder
Odor: Nearly odorless, faint tea-like smell
pH: 3.5 – 5.0 in aqueous solution (1% w/v)
Melting Point: Decomposes >220°C (no true melt)
Solubility: Moderately soluble in water, soluble in methanol and ethanol
Boiling Point: Not applicable
Vapor Pressure: Not applicable
Density: Approx. 1.5 g/cm³
Partition Coefficient: Log Kow -0.2 to 0.5 depending on assay
Other Data: Hygroscopic, sensitive to light and oxidation
Chemical Stability: Stable under recommended storage; degrades with heat, moisture, and strong sunlight
Reactivity: Reactive with strong oxidizers, acids, and alkalis
Possible Hazardous Reactions: None expected in normal use
Decomposition Products: Carbon monoxide, carbon dioxide, traces of phenolics when burned
Conditions to Avoid: Excess moisture, open flame, extreme temperature
Acute Toxicity: LD50 (oral, rat) > 2000 mg/kg, considered low toxicity at usual levels
Skin Contact: Not classed as irritant for intact skin; repeated exposure may cause dryness
Eye Contact: Mild, reversible irritation possible due to powder effect
Inhalation: May irritate upper respiratory tract if dusty
Ingestion: Large doses can cause GI upset, liver enzyme elevation reported rarely with excessive supplement use
Chronic Toxicity: No recognized longer-term effects from standard exposure in occupational settings
Mutation/Carcinogenicity: Not classified as carcinogen, no mutagenicity at tested concentrations
Other Toxic Effects: Allergic responses rare; monitor individuals with plant polyphenol sensitivities
Ecotoxicity: Limited toxicity data, low hazard expected for aquatic and terrestrial life at normal concentrations
Persistence and Degradability: Biodegradable compound, breaks down in soil and water under typical conditions
Bioaccumulation: Does not build up in biological systems appreciably
Mobility in Soil: Moderately mobile due to water solubility, not persistent
Other Adverse Effects: Large-scale releases could affect microbial balance in water or soil systems
Waste Treatment Methods: Dispose through regular chemical waste streams in accordance with local regulations
Contaminated Packaging: Clean before recycling or dispose as chemical waste
Environmental Precautions: Do not flush large amounts to drains; avoid uncontrolled environmental release
UN Number: Not regulated as a hazardous material for transport
Proper Shipping Name: Epigallocatechin Gallate
Hazard Class: Not classified
Packing Group: Not applicable
Marine Pollutant: No
Special Precautions: Avoid moisture and rough handling during transport
TSCA Status: Listed in the TSCA inventory for the United States
REACH Compliance: Pre-registered in the EU; always consult supplier documentation
California Prop 65: Not listed
Other National Inventories: Present in many national or regional inventories for food and cosmetic ingredients
Labelling Requirements: No special hazard labeling required under GHS criteria; consult local workplace safety regulations for specifics
