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Material Safety Data Sheet for Eicosapentaenoic Acid (EPA)

Identification

Product Name: Eicosapentaenoic Acid
Synonyms: EPA, 20:5 (n-3), 5,8,11,14,17-Eicosapentaenoic acid
Chemical Formula: C20H30O2
CAS No.: 10417-94-4
Recommended Use: Research, food supplements, pharmaceuticals
Supplier Details: Names and contact numbers for manufacturer or distributor, with emergency call numbers readily available

Hazard Identification

Classification: Not classified as hazardous under GHS criteria in pure form for most uses
Potential Health Effects: May cause mild irritation on skin or eyes, ingestion of large quantities can cause gastrointestinal upset
Signal Word: None
Hazard Statements: May cause minor irritation to eyes and skin, avoid inhaling dust or vapors
Pictograms: None applicable
Precautionary Statements: Wash hands thoroughly after handling, avoid contact with eyes, use proper ventilation

Composition / Information on Ingredients

Chemical: Eicosapentaenoic Acid
Concentration: 100% (pure substance; may also appear in oil mixtures with varied concentrations)
Other Identifiers: Major component in fish oil, can be sourced synthetically or from marine organisms
Impurities: Possible minimal presence of docosahexaenoic acid (DHA) or other omega-3 fatty acids in commercial preparations
Molecular Weight: 302.45 g/mol

First Aid Measures

Skin Contact: Remove contaminated clothing, wash affected area with plenty of water and soap, get medical attention if irritation persists
Eye Contact: Flush eyes with running water for several minutes, do not rub eyes; seek medical assistance if symptoms continue
Inhalation: Remove to fresh air, monitor breathing, seek medical care if symptoms like difficulty breathing develop
Ingestion: Rinse mouth with water, offer small amounts of water to drink, do not induce vomiting, consult a doctor if large quantities are ingested or symptoms occur
Advice for Medical Professionals: Treat symptomatically

Fire-Fighting Measures

Suitable Extinguishing Media: Foam, dry chemical, carbon dioxide, water spray (do not use a water jet directly)
Special Hazards: During combustion, releases carbon oxides and irritating fumes
Protective Equipment: Firefighters need self-contained breathing apparatus and protective clothing
Specific Fire Procedures: Cool containers with water, remove from fire area if safe to do so, keep unnecessary personnel away

Accidental Release Measures

Personal Precautions: Use protective gloves and goggles, ensure adequate ventilation, avoid creating dust
Environmental Precautions: Prevent entry to drains or watercourses, contain spill with sand, earth, or inert material
Methods for Cleanup: Absorb small spills with inert material, sweep up and collect in suitable, labeled containers for disposal, wash area with detergent and water

Handling and Storage

Safe Handling Advice: Wear proper protective gear, keep away from heat or open flames, use with adequate ventilation
Storage Requirements: Store in tightly closed containers in a cool, dry, and well-ventilated place, protect from light and moisture
Incompatibilities: Strong oxidants, bases, reducing agents
Special Shipping: Use food-grade or chemical-resistant containers, properly label packages for transport

Exposure Controls and Personal Protection

Exposure Limits: No official workplace exposure limits established
Engineering Controls: Local exhaust ventilation or fume hoods for bulk handling
Personal Protective Equipment: Gloves made of nitrile, safety goggles, lab coats, in case of insufficient ventilation use an appropriate respirator
Hygiene: Wash hands after handling, do not eat or drink in work areas, remove contaminated clothing before entering eating areas

Physical and Chemical Properties

Appearance: Pale yellow oily liquid (pure), colorless to light yellow in diluted solutions
Odor: Slightly fishy, characteristic of marine oils
Odor Threshold: Not established
pH: Not applicable
Melting Point: -54°C
Boiling Point: Not easily volatile, decomposes
Flash Point: Above 230°C (estimated, varies by purity)
Flammability: Combustible oily liquid
Solubility: Insoluble in water, soluble in ethanol, chloroform, ether
Partition Coefficient: log Kow >6
Vapor Pressure: Negligible at room temperature
Density: 0.92–0.94 g/cm³
Viscosity: Moderate, typical of fatty acids

Stability and Reactivity

Chemical Stability: Stable under normal storage and handling conditions, sensitive to air, light, and heat
Reactivity: May react with strong oxidizers, peroxides
Hazardous Decomposition: Carbon monoxide, carbon dioxide, irritating fumes
Polymerization: Will not occur under standard conditions
Other Information: Prolonged exposure to air leads to gradual oxidation, resulting in rancidity and degradation

Toxicological Information

Acute Toxicity: Low toxicity, oral LD50 (rat) > 2000 mg/kg
Skin and Eye Irritation: Mild irritation possible on prolonged contact
Sensitization: Not a known sensitizer
Carcinogenicity: Studies do not indicate carcinogenic or mutagenic effects
Other Effects: Overconsumption by ingestion can lead to gastrointestinal upset, nausea, or diarrhea
Long-Term Exposure: No evidence of chronic toxic effects in regular dietary or supplemental usage, as indicated in multiple clinical studies

Ecological Information

Ecotoxicity: Readily biodegradable, minimal environmental hazard in typical quantities
Bioaccumulation: Unlikely based on low water solubility, rapid metabolism in most organisms
Mobility in Soil: Binds strongly to soil, limited mobility
Aquatic Toxicity: Not toxic to aquatic life at environmentally relevant concentrations
Persistence: Degrades relatively quickly in the environment, especially in the presence of light and oxygen

Disposal Considerations

Waste Treatment Methods: Dispose of according to local, regional, national, and international regulations
Disposal of Containers: Rinse with appropriate solvent and send to recycling or proper waste facility
Special Instructions: Do not discharge into sewers or waterways, handle spillages as chemical waste, consult waste contractor if unsure

Transport Information

UN Number: Not regulated as dangerous goods for transport
Transport Hazard Class: Not classified as hazardous
Packing Group: Not assigned
Environmental Hazards: No specific hazards identified
Special Precautions: Protect from physical damage, direct sunlight, or extreme temperatures during transport

Regulatory Information

Safety, Health, and Environmental Regulations: Complies with REACH, TSCA, and most global chemical inventories
Labeling Requirements: No risk or safety phrases required under EU CLP Regulation for pure substance
Compliance: Meets standards for food use where purity requirements are followed
Other Specific Regulations: May be subject to additional rules and standards for nutraceutical or pharmaceutical use based on country and region