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Material Safety Data Sheet: DL-Calcium Pantothenate

Identification

Product Name: DL-Calcium Pantothenate
Chemical Name: Calcium 3-[(2,4-dihydroxy-3,3-dimethylbutanoyl)amino]propanoate
Synonyms: Calcium D-Pantothenate, Vitamin B5 Calcium Salt
CAS Number: 137-08-6
Recommended Use: Nutritional supplement, pharmaceutical intermediate
Manufacturer: [Manufacturer Name and Contact Information]
Emergency Contact: [Emergency Telephone Number]

Hazard Identification

Classification: Not hazardous under GHS classification
Hazard Statements: Not classified as hazardous; may cause mild irritation to eyes, skin, and respiratory system if exposed to large amounts
Signal Word: None required
Pictograms: None mandated
Precautionary Statements: Avoid breathing dust; wash hands thoroughly after handling; use protective gear to avoid direct contact

Composition / Information on Ingredients

Chemical Identity: DL-Calcium Pantothenate
Concentration: 99% or above
Impurities: Trace moisture; low-level contaminants from manufacturing process
Molecular Formula: C18H32CaN2O10
Molecular Weight: 476.5 g/mol

First Aid Measures

Inhalation: Move person to fresh air; provide oxygen if breathing becomes difficult; seek medical attention if symptoms persist
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing; consult a doctor if irritation develops
Eye Contact: Rinse immediately with clean water for at least 15 minutes, holding eyelids open; seek medical help if redness or discomfort does not subside
Ingestion: Rinse mouth with water; do not induce vomiting; offer water to drink; call a physician if symptoms appear

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide
Specific Hazards: May form carbon oxides, calcium oxides, and nitrogen oxides on thermal decomposition
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective suit
Special Procedures: Cool exposed containers with water spray to reduce pressure build-up; avoid inhalation of combustion products

Accidental Release Measures

Personal Precautions: Wear appropriate personal protection including gloves, goggles, and a dust mask; ventilate area
Environmental Precautions: Prevent further leakage or spillage if safe to do so; avoid discharge into drains or surface water
Cleanup Methods: Carefully scoop or sweep up without generating dust; place in suitable containers for proper disposal; flush residual area with water while avoiding runoff into the environment

Handling and Storage

Handling: Minimize dust generation; use in a well-ventilated area; avoid inhalation and contact with skin or eyes; ensure proper training for those handling large amounts
Storage: Store in tightly closed containers in a cool, dry, well-ventilated place; keep away from moisture, strong acids, and incompatible materials; avoid temperature extremes to protect stability

Exposure Controls and Personal Protection

Occupational Exposure Limits: No specific limits set for DL-Calcium Pantothenate
Engineering Controls: Use local exhaust ventilation or fume hood to minimize exposure
Personal Protective Equipment: Wear protective gloves (nitrile recommended), safety goggles, and a lab coat; use a dust respirator if dust becomes airborne; practice good hygiene by washing hands after handling
Environmental Controls: Ensure proper containment to avoid releases to the workplace or environment

Physical and Chemical Properties

Appearance: White, odorless, crystalline powder
Melting Point: Begins to decompose above 190°C
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Freely soluble in water; practically insoluble in ethanol and ether
pH (10% solution): Ranges between 6.8 and 8.0
Odor: No significant odor
Density: Approximately 1.25 g/cm³

Stability and Reactivity

Chemical Stability: Stable under normal conditions; sensitive to humidity and high temperature
Conditions to Avoid: Excessive heat, exposure to moisture, open flame
Incompatible Materials: Strong acids, strong bases, oxidizers
Hazardous Decomposition Products: May emit toxic fumes of carbon monoxide, carbon dioxide, calcium oxides, and nitrogen oxides if heated to decomposition

Toxicological Information

Acute Toxicity: Low toxicity; LD50 (oral, rat) > 8000 mg/kg
Skin Irritation: May cause mild irritation after prolonged contact
Eye Irritation: May cause slight temporary discomfort
Long-term Effects: No confirmed chronic effects at occupational exposure levels; not classified as carcinogenic or mutagenic
Sensitization: Not expected to cause sensitization
Inhalation: Dust inhalation can cause mild irritation to respiratory tract

Ecological Information

Ecotoxicity: Not expected to be harmful to aquatic or terrestrial life at typical environmental concentrations
Persistence and Degradability: Readily biodegradable and unlikely to accumulate in the environment
Bioaccumulation Potential: Low due to high solubility and metabolism by living organisms
Mobility in Soil: Expected to be highly mobile in water; may leach through soil if released
Other Adverse Effects: Data suggests negligible impact on the ecosystem under normal handling and use

Disposal Considerations

Waste Treatment Methods: Dispose according to local, regional, and national regulations
Product Disposal: Sweep up and place in an appropriate closed container for disposal; do not discharge to sewer
Contaminated Packaging: Rinse containers before recycling or disposal; manage rinsate as chemical waste
Precautions: Prevent material from entering waterways and drains

Transport Information

UN Number: Not regulated
UN Proper Shipping Name: Not classified as hazardous for transport
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions: Protect from excessive moisture during transportation; keep container sealed

Regulatory Information

International Inventories: Listed on TSCA (USA), EINECS (EU), DSL (Canada), AICS (Australia)
Labeling Requirements: Not subject to labeling under current GHS standards
OSHA Status: Not considered hazardous under OSHA HCS
SARA Title III: Not listed as a hazardous substance
Other Regulations: Complies with relevant local, federal, and international standards for workplace safety and chemical management