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Material Safety Data Sheet (MSDS) for Disodium 5'-Guanylate

Identification

Product Name: Disodium 5'-Guanylate
Chemical Formula: C10H12N5Na2O8P
CAS Number: 5550-12-9
Synonyms: Disodium Guanylate, E627, Sodium Guanylate
Intended Use: Flavor enhancer in foods, ingredient for industrial use
Manufacturer: Information available on request
Contact Number: Information accessible from supplier's emergency response line
Address: As recorded on shipping documentation

Hazard Identification

GHS Classification: Not classified as hazardous under OSHA regulations
Signal Word: None
Pictograms: No pictogram assigned
Known Hazards: Eye irritation, mild skin irritation if exposed in large amounts, dust inhalation may irritate respiratory system
Routes of Entry: Inhalation, skin contact, ingestion
Target Organs: Eyes, respiratory tract, skin
Precautionary Statements: Avoid inhaling dust or vapor, minimize skin and eye contact, use only with adequate ventilation
Symptoms: Eye discomfort, sneezing, mild itching on skin, coughing when inhaled

Composition / Information on Ingredients

Chemical Name: Disodium 5'-Guanylate
Concentration: >98%
Impurities: Maximum 2% sodium chloride or trace organic salts
Molecular Weight: 407.18 g/mol
Component: Single substance
Additives: Not present
Hazardous Components: No known hazardous impurities in food-grade product
Exposure Limits: No established workplace exposure limit

First Aid Measures

Eye Contact: Rinse cautiously with water for at least 15 minutes, keep eyelids open, seek medical attention if pain or redness persists
Skin Contact: Wash skin thoroughly with soap and water, remove contaminated clothing, consult a physician for ongoing irritation
Inhalation: Move person to fresh air, encourage slow, deep breathing, consult medical personnel if cough or discomfort continues
Ingestion: Rinse mouth with water, do not induce vomiting, drink water to dilute substance, seek medical advice if feeling unwell
Notes for Medical Staff: Symptomatic treatment, monitor for allergic reaction

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, water spray, foam, carbon dioxide
Unsuitable Media: None identified
Hazardous Combustion Products: Irritating fumes may form, including nitrogen oxides and phosphorus oxides
Special Equipment: Firefighters use self-contained breathing apparatus, full protective gear
Specific Hazards: Dust explosion risk if fine particles suspended in air
Protective Actions: Remove personnel from area, prevent runoff from entering drains or water systems

Accidental Release Measures

Personal Precautions: Wear protective gloves and goggles, avoid breathing dust, ensure ventilation in confined areas
Environmental Precautions: Contain spill, prevent product from entering watercourses
Methods for Cleanup: Sweep up product without generating dust, place in labeled waste container, clean area with water
Emergency Procedures: Evacuate unnecessary personnel, alert response team

Handling and Storage

Safe Handling: Use personal protective equipment, avoid creating dust clouds, do not eat or drink during handling
Safe Storage: Store in tightly closed containers, protect from moisture and heat, keep in a dry, well-ventilated location
Incompatibilities: Strong oxidizers, reducing agents
Storage Temperature: Room temperature (15-25°C) recommended
Bulk Storage: Avoid direct contact with wood or metal storage bins

Exposure Controls and Personal Protection

Engineering Controls: Use local exhaust ventilation, process enclosure when large amounts handled
Respiratory Protection: NIOSH-approved dust mask for dusty conditions
Eye Protection: Safety goggles
Skin Protection: Chemical-resistant gloves, lab coat or apron
Hygiene Measures: Wash hands and face thoroughly after working, remove contaminated clothing before eating
Environmental Controls: Avoid release to surface water or drains

Physical and Chemical Properties

Appearance: White crystalline powder
Odor: Odorless
pH (1% solution): Approximately 7
Melting Point: Decomposes above 250°C
Boiling Point: Not applicable
Solubility in Water: Soluble (approximately 30 g/L at 20°C)
Specific Gravity: 2.0-2.3
Flash Point: Not flammable
Vapor Pressure: Not volatile
Partition Coefficient: Not applicable

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Reactivity: No dangerous reactions under normal use
Incompatible Materials: Strong acids, strong oxidizers
Decomposition Products: Releases oxides of carbon, nitrogen, and phosphorus when heated to decomposition
Hazardous Polymerization: Will not occur

Toxicological Information

Acute Toxicity: LD50 (oral, rat) >2000 mg/kg
Chronic Effects: No evidence of cumulative effects from low-level exposure
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Sensitization: No reports of skin or respiratory sensitization
Mutagenicity: Data indicate no mutagenic effect
Medical Conditions Aggravated: Asthma or other respiratory conditions if dust inhaled
Potential Health Effects: Excess intake may cause gastrointestinal discomfort in sensitive individuals

Ecological Information

Toxicity: Not toxic to aquatic life in low concentrations
Persistence and Degradability: Rapidly biodegradable
Bioaccumulation: Not expected
Mobility in Soil: High water solubility promotes mobility, but degrades quickly
Other Adverse Effects: Nutrient-rich spills may promote algal blooms in water bodies

Disposal Considerations

Waste Treatment Methods: Dispose of unused material in accordance with local regulations
Packaging Disposal: Rinse empty containers with water and offer for recycling or disposal
Hazardous Waste: Not classified as hazardous
Environmental Precautions: Do not discharge into sewers or waterways

Transport Information

UN Number: Not regulated
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Transport Label Required: None
Marine Pollutant: No
Special Precautions: Protect from moisture during transit, keep in original packaging

Regulatory Information

Inventory Status: Listed on US TSCA, EU EINECS, Japan ENCS, and other national inventories
Labeling Requirements: No specific hazard labeling required by GHS
Restrictions on Use: Approved as a food additive (E627) within regulated limits
SARA Title III: Not subject to reporting
California Proposition 65: Not listed
Other Information: Compliant with FDA and EFSA food additive standards, no REACH restrictions reported