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The Journey of Dimethyl Sulfone (MSM): From Discovery to Modern Uses

Historical Development

People have known about sulfur’s power for healing since the days when Greek physicians wrote recipes by hand. In the 1970s, Dr. Robert Herschler and Dr. Stanley Jacob started working with MSM after noticing how animals grazed on certain grasses and ended up with better coats. Their lab at Oregon Health & Science University figured out the groundwork for using it in humans, and their studies paved the way for how MSM shows up in supplements and wellness products. Science keeps building on these early findings, but those first hot flasks and beakers helped millions of folks who now look to MSM for daily aches or creaky joints.

Product Overview

MSM, also known as methylsulfonylmethane or dimethyl sulfone, comes out of the world’s sulfur cycle—meaning it starts in ocean plankton before turning up as a white, odorless powder. You’ll see it on shelves mostly in capsule or crystal form. Companies pack it into creams for arthritis, pet food for mobility, and shampoos promising thicker hair. Health food stores make a big fuss about how “pure” their MSM is, trying to speak to wary customers who want supplements cleaner than what you’d get in a standard pill bottle.

Physical & Chemical Properties

This compound won’t turn heads in a chemistry lab, but a closer look reveals what makes MSM special. Its melting point sits at 109°C, so it holds together at room temperature. MSM dissolves well in water, making it easy to mix into drinks or blend with lotions. No strong taste or smell lingers, which helps people try it without complaints. In structure, MSM brings two methyl groups and one sulfonyl group, which most textbooks call (CH₃)₂SO₂. These bits help it glide through the body’s tissues, cross cell walls, and carry its sulfur payload where it’s needed—especially in cartilage or skin.

Technical Specifications & Labeling

Labels on MSM products should detail the percentage of active sulfur, origin of materials, and screening for contaminants like heavy metals. Reputable brands run their material through HPLC or GC-MS devices to confirm purity (the gold standard hits over 99.8%). International standards, such as FCC and USP listings, guide companies to ensure what’s in the tub matches what’s on the label. Any dyes or fillers need listing for folks with allergies. Good labeling shows where MSM comes from, if it follows vegan practices, and if it's been tested for bacteria or mold—details essential for trust.

Preparation Method

Companies make MSM from DMSO (dimethyl sulfoxide), which comes from wood pulp during paper production. Chemical engineers oxidize DMSO—by blowing air or another gentle oxidizing agent over it—under strict temperature and pressure to turn it into MSM while avoiding odd byproducts. Purifying MSM involves repeated crystallization, filtering out anything that’d upset sensitive users. My time in a chemical plant taught me that making food ingredients often looks like making pharmaceuticals: strict controls, clean equipment, and endless logs proving every step got checked.

Chemical Reactions & Modifications

In the lab, MSM acts as a reliable sulfur donor, which makes it useful for things beyond just dietary supplements. Some chemists swap out the methyl groups for more exotic partners, creating new sulfone-based compounds. MSM doesn’t break down easily—stable even after being heated or left on shelves for years. Some researchers test its limits by mixing it with other solvents, looking for ways to boost pain relief. MSM can also help deliver drugs deeper into tissues, which is why some skin creams use it alongside anti-inflammatories.

Synonyms & Product Names

Dimethyl sulfone, methylsulfonylmethane, and just MSM—these are all different ways to say the same thing. Some brands slap on catchy names like OptiMSM or Pure MSM, but the core ingredient remains the same. In international trade, codes like CAS 67-71-0 or EC 200-665-9 track the compound between factories and borders. Buyers in farm animal industries talk about “organic sulfur” supplements or feed additives, sometimes confusing customers who see it next to MSM intended for human use.

Safety & Operational Standards

MSM rates high in safety among most nutritional chemicals. Studies show it’s tolerated at doses up to 4 grams per day for months at a time. Sometimes it gives mild stomach trouble, but serious problems remain rare. Food and supplement makers obey rules from agencies like the FDA or EFSA, tracking each batch and logging everything from storage temperature to batch purity. At the plant, workers avoid skin or inhalation exposure just to be safe, even though the material rarely causes allergic reactions. GMP practices—lock-and-key ingredient storage, gear for every technician, regular third-party audits—make the industry safer for both workers and consumers.

Application Area

MSM reaches into health supplements, therapy creams, pet nutrition, and even cosmetics. People swallow it for joint comfort, muscle soreness, or skin health. It pops up in lotions for arthritis or eczema, promising to soothe burning or cracked skin. Vets put MSM in horse feed and dog chews, hoping to extend working years for animals with heavy joints. Haircare and beauty brands claim MSM adds strength and shine, feeding the rise of wellness products that blend the chemical across categories. It’s become a go-to for the aging population and athletes alike, making it a mainstay in wellness aisles.

Research & Development

Recent years saw researchers dig deeper into MSM’s effects on inflammation and pain. Small human trials link it to reduced joint discomfort and faster recovery from exercise, but some studies still carry bias or small sample sizes. Labs investigate how MSM interacts with cell membranes, especially for skin or cartilage repair. Innovations focus on more absorbable forms, mixable powders, and bioavailable gels. Academics push for larger, placebo-controlled trials in arthritis or allergies, hoping to get beyond anecdotes into hard science. The supplement industry funds some of this work, but independent groups increasingly chase answers to claims made by booming markets.

Toxicity Research

Toxicologists found MSM to have a high safety threshold, with animal studies showing no harm even at sky-high doses. Reports of nausea or headache at larger doses appear, especially among sensitive users, but no lasting toxicity surfaces in published literature. Major reviews cover reproductive safety, allergy potential, and long-term use—highlighting just rare, mild side effects. That said, cheap or impure MSM, contaminated with leftover DMSO or solvents, could mean trouble; that’s why third-party certification matters to the end user. As seen in other supplement cases, poor monitoring—not the ingredient itself—usually triggers recalls or health scares.

Future Prospects

MSM’s future looks busy and a bit crowded, as companies try to slot it into more beauty, veterinary, and sports nutrition formulas. Product developers want new delivery systems—think slow-release capsules, topical sprays, or blends with curcumin or hyaluronic acid—hoping for stronger and swifter results. Wider studies might pinpoint exactly how MSM helps some people but not others, fueling the trend of “personalized” nutrition. If regulations tighten and consumers get smarter about quality, MSM could remain a staple for decades, driven by the demand for gentle, natural ways to manage pain, fight inflammation, and improve overall well-being.




What are the health benefits of taking Dimethyl Sulfone (MSM)?

What MSM Brings to the Table

Over the last decade, more people have started looking beyond standard painkillers and prescription bottles to support their joints and overall vitality. Dimethyl Sulfone, better known as MSM, gets plenty of attention in arthritis circles, health food stores, and fitness communities. It’s a sulfur compound that occurs naturally in some foods like broccoli, alfalfa, and garlic. Sulfur plays a crucial role in everyday living, helping build connective tissue, cartilage, and supporting healthy skin.

Support for Joints and Muscle Recovery

One thing that draws attention to MSM revolves around joint pain. Clinical trials published in journals like Osteoarthritis and Cartilage show that MSM can ease swelling and improve function in people with knee osteoarthritis. People who have tried everything from ice packs to ibuprofen sometimes finally get some relief, reporting fewer aches and easier movement after a few weeks with MSM. As someone who struggled with post-run soreness and stiff knees, I found that supplementing sulfur (through food and MSM) seemed to help get me back out the door sooner than the old days.

Athletes and active folks use MSM for muscle soreness and recovery. In one small double-blind study, runners who took MSM before a half marathon felt less muscle pain and returned to their routines faster. These real-world results matter because many of us want to train hard but not limp around for days after.

MSM and Inflammation

Chronic inflammation often sneaks up as the hidden culprit behind fatigue, stubborn weight, and chronic disease. MSM works by blocking some of the molecular signals that ramp up inflammation. Research published by the National Institutes of Health shows changes in markers like C-reactive protein (CRP), signaling that MSM may help dial down this inflammation. Alleviating inflammation doesn’t just help pain—lots of people report clearer skin, fewer allergy flare-ups, and lighter moods.

Allergy and Immune Support

For those who struggle every spring, MSM gets some high marks for calming allergies. A study in the Journal of Alternative and Complementary Medicine found that MSM reduced sneezing and stopped eyes from watering so much during allergy season. The immune system has a delicate balance, and sulfur supports both detox and immune defense. People with skin irritation and rosacea sometimes swear by MSM creams, and here, sulfur’s long history in dermatology gets a chance to shine.

Safety and How to Use It

MSM supplements show a strong safety profile, with few serious side effects reported in studies—even across doses much higher than typical daily use. A large section of the population misses dietary sulfur, especially anyone sticking to highly processed foods, so adding MSM can help fill that nutritional gap. Still, it pays to be thoughtful about how you use it. High-quality studies often use doses between 1,500–3,000 mg per day, split across meals. Starting small and watching for digestive upset works best. Talking it over with a doctor or dietitian keeps everything above board, especially for those with pre-existing conditions or other supplements.

Moving Forward With MSM

Demand for natural, evidence-backed remedies keeps growing. MSM stands out because it’s affordable, easy to find, and has enough science behind it to justify some optimism. More robust research would help nail down long-term benefits for conditions like arthritis and muscle pain, but anyone looking for a simple way to support their joints, immunity, and recovery finds plenty of reason to give MSM a look.

Are there any side effects associated with MSM supplementation?

Understanding MSM and Where Its Hype Comes From

MSM, or methylsulfonylmethane, has gained a spot in the supplement aisle next to big names like glucosamine and chondroitin. People chasing joint comfort, athletes hoping to shorten recovery, even folks wanting shinier hair — MSM catches their attention. It sounds natural. After all, sulfur is essential to our bodies, showing up in muscles, skin, and hair. With all those wellness claims, MSM can look like a fast pass to better days. Still, no pill is completely hassle-free, and shining a light on side effects helps us decide what’s right for our health.

Digestive Disturbances and Common Complaints

Stomach troubles land at the top of MSM’s downside. I once tried MSM for joint pain. My knees didn’t thank me much, but my gut sure noticed. Mild cramping, loose stools, even a bit of heartburn — these complaints pop up in clinical studies and consumer reports. The stomach has to process the extra sulfur, and some folks seem to react more than others. The good news: most tummy issues fade over time or with a lower dose. Still, anyone with a sensitive digestive tract may want to tread gently.

Allergic Reactions: Rare but Possible

HSkin rashes, itching, swelling — true allergic reactions are rare with MSM. Yet no supplement is totally off the hook. The stories do exist, especially for folks who already have sulfur allergies from other sources. I’ve met a few people who try MSM and end up with hives. The advice from doctors stays simple: start low, watch for changes, and give it up if things go sideways. MSM comes from natural sources, but once in a bottle or capsule, it’s still a concentrated chemical hitting your system.

Interactions with Medication

This one deserves attention. MSM affects the liver’s metabolism. If someone takes blood-thinners, diabetes medications, or has a full medicine cabinet, it’s best to talk with a healthcare provider. MSM can raise bleeding risk when paired with certain drugs. Researchers have caught changes in how the body handles other meds when people add MSM to their daily routine. Mixing supplements and prescriptions is never simple. A quick check-in with a doctor saves a lot of headaches — or worse, bleeding.

Long-Term Safety Still Needs Proof

Plenty of MSM studies look only at short-term use, sometimes just a few weeks. There’s not much out there about what happens after years of daily MSM or in higher doses. My own trust radar swings toward caution when researchers themselves point out their data gaps. Aging kidneys and livers process substances more slowly, so older adults especially need to double-check before layering on something new. Without long-term safety data, it makes sense to use MSM only as needed, avoiding the “more is better” temptation.

Quality Concerns and Purity Issues

The supplement world isn’t the Wild West, but it’s not the pharmacy either. Lab tests have spotted MSM products that contain contaminants or switch up the labeled dose. That’s why I stick to brands tested by independent labs, and urge friends to do the same. Buying cheap or shady supplements can introduce risks far beyond what’s on the label. The lesson stands: check for third-party certification and steer clear of too-good-to-be-true deals.

Smart Choices and Safer Use

Starting with a low dose and adding it to a meal makes MSM less likely to upset the gut. Sharing all supplements with a primary care provider lines up with best practices. People with sensitive bodies or many medical conditions should pause before experimenting. MSM isn’t snake oil, but it’s not a miracle, either. For many folks, an honest talk with the doctor and focusing on the basics — movement, rest, and nutrition — offers real returns without the risk of surprise side effects.

What is the recommended dosage for MSM?

Understanding MSM and Its Uses

Methylsulfonylmethane, or MSM for short, shows up in health store bottles everywhere you look. People pop these pills and scoop the white powder into water, hoping for relief from joint aches, inflammation, or just to support daily wellness. The shelves call out claims about flexibility, clearer skin, and thicker hair. It’s easy to see why folks get curious and want to know how much to take. Over the years, people have heard all sorts of doses—from a sprinkle in a smoothie to spoonfuls in a glass, often without much direction from trustworthy sources.

What Science Tells Us About MSM Dosage

MSM supplements have been studied for several reasons: osteoarthritis pain, allergies, and even skin care. The most common dosage in research circles sits between 1,500 milligrams and 6,000 milligrams daily. A clinical trial from 2006, published in “Osteoarthritis and Cartilage”, used 3,000 mg two times a day for joint pain, totaling 6,000 mg, with participants reporting improvement over three months. Many find 3,000 mg to 4,000 mg daily hits a sweet spot for trying MSM without running into too many gut troubles.

Safety always tops the list before trying new supplements. A study published in the “Journal of Toxicology” in 2007 tested up to 6,000 mg daily, with people tolerating it well over twelve weeks. Reported side effects include mild stomach discomfort or bloating, especially when jumping into higher amounts quickly.

Why Dosage Matters

Dosing isn’t just about matching a study or copying a friend’s ritual. Everyone brings a unique health story—liver and kidney function, family history, current medications. People sometimes forget about drug interactions. MSM can thin blood slightly, so pairing with blood thinners deserves a doctor’s opinion before starting. Folks with sensitive guts or a track record of allergies to sulfa drugs also want to check in before adding MSM to the daily lineup.

Supplement companies and influencers love tossing around numbers, but not every body absorbs or processes MSM the same way. My own experience, and the stories from friends in arthritis support groups, show that starting with a low dose—like 1,000 mg a day—and slowly moving up to 3,000 mg brings fewer stomach complaints. Listening to your stomach’s signals means more than following dosing promises on a label.

What Works in Real Life

Tablets, powders, and capsules—each form has its fans. Many mix MSM powder into juice because of its bitter aftertaste, and this seems to settle best on a full stomach. I started by using half the label’s listed amount to test my own tolerance. That personal trial period gave me enough feedback for comfort and real benefits without any bathroom sprints or queasy stomach problems. People who keep an eye out for possible side effects usually notice mild issues early if they listen to their bodies and stay honest about the changes they feel.

Moving Forward: Smart MSM Use

Doctors who understand dietary supplements remain a goldmine for safe and effective use. ConsumerLab, the National Institutes of Health, and Mayo Clinic run balanced updates for supplement guidance based on current research, not just anecdotal stories. While most healthy adults tolerate 1,500 mg to 3,000 mg just fine, checking labs and symptoms now and then stays smart. Proper storage and buying from trustworthy suppliers help avoid impurities that sometimes sneak into off-brand powders.

Education about MSM relies on learning from solid evidence, balancing that with honest self-observation, and keeping physicians involved. Approaching any new supplement with respect helps people avoid risks and get the most value for their health investment.

Can MSM be used for joint pain and arthritis?

Exploring the Role of MSM in Joint Health

Over the years, more people have started reaching for MSM (methylsulfonylmethane) as a supplement, especially those living with achy joints or dealing with arthritis. I remember seeing MSM powder stacked alongside glucosamine and chondroitin in the pharmacy, all promising some relief. For folks who struggle to stand up without a wince or who wake up with stiff fingers, the search for real help never feels optional. MSM might have a reputation as just another supplement, but it deserves a closer look—especially for those frustrated by slow progress or side effects from regular pain meds.

The Science Behind MSM and Joints

Our joints take a daily beating, whether it’s a job that keeps you on your feet or a sports injury that never healed quite right. MSM naturally occurs in some foods and forms part of the sulfur our bodies use for everything from building connective tissue to skin health. The real question many ask: is there strong evidence that MSM can make a measurable difference for people limping around with arthritis or daily soreness?

Several studies point to MSM showing moderate promise. A small trial published in Osteoarthritis and Cartilage followed people with knee osteoarthritis who took MSM capsules over 12 weeks. Participants reported less pain, improved mobility, and could function a bit better day-to-day. Other research backs up the idea, at least in mild forms of arthritis, that MSM may cut down on pain and inflammation that comes with joint problems.

Still, no supplement erases arthritis or reverses years of wear and tear. MSM seems to work mainly through reducing inflammatory signals (like cytokines) and providing sulfur for cartilage repair. The catch? Much of the research covers short time frames and uses small groups. Health agencies haven’t called MSM a miracle drug, but some doctors see it as a helpful part of an overall plan—especially since side effects tend to be mild for most people.

Personal Experience and the Broader Impact

My own experience with MSM echoes what friends and clients share: it’s not a painkiller, and it won’t replace physical therapy or medical advice. People feel the difference over weeks, not days. Some find they can walk further before their knees complain, or sleep a little better because their hands don’t throb all night. Others feel no change at all. It’s frustrating that relief isn’t guaranteed, but those glimpses of freedom from pain keep some coming back for more.

The supplement world sometimes gets a bad rap, and for good reason. There’s always a risk when buying products that aren’t strictly regulated. That’s why quality matters—third-party tested brands, honest labeling, and open discussions with a trusted healthcare provider help people make better choices. If a loved one asks about MSM, I suggest they start with reliable information and talk openly with their doctor before diving in.

Moving Forward with Joint Pain Solutions

For anyone feeling let down by mainstream pain relief options, MSM can be part of a toolkit, rather than a silver bullet. Combining MSM with exercise, a good diet, stress management, and consistent medical care usually works best. The journey toward comfort and mobility runs differently for everyone, but hearing from others who found small wins—like reaching for a mug or playing with grandkids without sharp pain—offers hope. Safe, personalized choices move people forward, even when progress feels slow.

Is MSM safe to take with other supplements or medications?

Sorting Through the Buzz About MSM

MSM—methylsulfonylmethane—shows up on vitamin shop shelves with promises of joint comfort, faster recovery, and hair, skin, and nail support. Plenty of people try it. You see marathon runners knock back capsules, busy moms add a scoop to morning shakes, and folks with creaky knees swear it makes a clear difference. The question pops up a lot: Is MSM safe if you already take other vitamins or medications?

Mixing Supplements: What We Know

I've seen the supplement aisle grow full of promises. MSM gets a lot of support, especially for folks looking to reduce minor aches. The natural instinct says, "It's just sulfur—my body needs sulfur, right?" Yes, sulfur matters. But it's never just about a single nutrient. You stack supplements, and suddenly interactions turn into a concern.

For most people, MSM doesn't raise alarm bells when used alone or in low doses. The biggest studies around joint health, like those published in Osteoarthritis and Cartilage, found people tolerated MSM up to 6 grams daily for several months without dangerous side effects. Common reactions—mild stomach upset or headaches—aren’t unique to MSM, since plenty of strong-tasting compounds upset the gut.

Down to the Details: Supplements and Medications

The picture changes if someone takes prescription medications. MSM's major claim—it helps with inflammation—raises questions about its influence on the immune system and liver, where both drugs and supplements often get processed. A handful of animal studies suggest MSM doesn't interfere much with enzymes in the liver that handle most drugs. No blockbuster warnings about MSM making common meds, like ibuprofen or blood pressure pills, less effective. Still, scientists haven't studied every possible mix.

Stacking MSM with other anti-inflammatory supplements like turmeric, glucosamine, or fish oil shows up in research, usually without big trouble. Some users report more energy or less pain, but watch for blood-thinning effects. MSM's impact isn't usually as strong as aspirin or warfarin, but doubling up with other blood-thinners without medical input opens the door to excess bruising or bleeding, especially in people over 65.

Why Trust In Health Advice Matters

There’s a lot of noisy marketing behind MSM and supplement culture. Brands want you to double up on the latest “joint health stack.” You owe it to your own health to dig deeper. Don’t just trust online forums or product labels. Groups like the National Institutes of Health keep tabs on supplement safety, and their reports build on scientific studies—not just one-off experiences.

Doctors and pharmacists study drug-supplement interactions for a reason. They ask about everything on your supplement list. I’ve watched friends leave out MSM when discussing meds, thinking it doesn’t count, only to learn their doctor spotted a risk related to another supplement. Sharing your full list of what you take—brand, dose, frequency—lets your care team spot patterns that aren’t clear on a product insert.

Steps Toward Safer Supplement Use

A careful person checks MSM’s role with existing supplements or medicines before routine use. Read up on credible sources like MedlinePlus or Mayo Clinic. Remember, companies don’t need to prove long-term safety before offering new formulas. Watch for new symptoms, and if something feels off after starting MSM alongside other pills, flag it to your doctor.

The market moves fast, but taking a pause before adding another powder or pill gives your body a better chance to adapt and alerts you sooner to an interaction that slips past even the most detailed label.

Dimethyl Sulfone MSM
Names
Preferred IUPAC name Methylsulfonylmethane
Other names Methylsulfonylmethane
Methyl sulfone
Sulfonylbismethane
MSM
DMSO2
Pronunciation /daɪˈmiːθəl ˈsʌlfoʊn ɛm ɛs ɛm/
Preferred IUPAC name methylsulfonylmethane
Other names Methylsulfonylmethane
MSM
Sulfonylbismethane
DMSO2
Dimethyl sulphonyl
Methyl sulfone
Pronunciation /daɪˈmiːθəl ˈsʌlfoʊn ɛm ɛs ɛm/
Identifiers
CAS Number 67-71-0
3D model (JSmol) `3Dmol.js('Molecule', 'C S(=O)(=O) C')`
Beilstein Reference 1469140
ChEBI CHEBI:27568
ChEMBL CHEMBL1230986
ChemSpider 83440
DrugBank DB01923
ECHA InfoCard echa.europa.eu/substance-information/-/substanceinfo/100.008.042
EC Number 231-784-4
Gmelin Reference 8335
KEGG C06741
MeSH D10.570.549.500.700
PubChem CID 7518
RTECS number PV6210000
UNII J2Z13VCM0V
UN number UN1845
CompTox Dashboard (EPA) DTXSID4020249
CAS Number 67-71-0
3D model (JSmol) `MSM` (Dimethyl sulfone), in JSmol/3D model format as a string: ``` CS(=O)(=O)C ``` This is the **SMILES** string, which is used by JSmol as input to generate the 3D structure.
Beilstein Reference 1131989
ChEBI CHEBI:27647
ChEMBL CHEMBL1236
ChemSpider 8656
DrugBank DB03255
ECHA InfoCard ECHA InfoCard 100.007.438
EC Number 220-256-6
Gmelin Reference 90352
KEGG C02337
MeSH D013063
PubChem CID 7518
RTECS number PV6210000
UNII J2IY779W9G
UN number UN number: "UN2811
Properties
Chemical formula C2H6O2S
Molar mass 94.13 g/mol
Appearance White crystalline powder
Odor Odorless
Density 1.31 g/cm³
Solubility in water soluble
log P -1.2
Vapor pressure 0.67 hPa (at 25 °C)
Acidity (pKa) ~31
Basicity (pKb) Basicity (pKb): 15.5
Magnetic susceptibility (χ) -9.80·10⁻⁶ cm³/mol
Refractive index (nD) 1.432
Viscosity 10 - 20 cP
Dipole moment 3.61 D
Chemical formula C2H6O2S
Molar mass 94.13 g/mol
Appearance White crystalline powder
Odor Odorless
Density 1.31 g/cm3
Solubility in water 34 g/100 mL (20 °C)
log P -1.2
Vapor pressure 0.67 hPa (20 °C)
Acidity (pKa) ~31
Basicity (pKb) Product does not possess basicity (pKb); Dimethyl Sulfone (MSM) is neutral.
Magnetic susceptibility (χ) -12.2×10⁻⁶ cm³/mol
Refractive index (nD) 1.402
Viscosity 25–40 cP
Dipole moment 3.61 D
Thermochemistry
Std molar entropy (S⦵298) 99.5 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -564.6 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -1404.7 kJ/mol
Std molar entropy (S⦵298) 151.0 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -564.6 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -1428 kJ/mol
Pharmacology
ATC code A15AA05
ATC code M02AX10
Hazards
GHS labelling GHS02, GHS07
Pictograms GHS07
Signal word Warning
Hazard statements Not a hazardous substance or mixture according to the Globally Harmonized System (GHS).
NFPA 704 (fire diamond) 1-0-0
Flash point 130 °C
Autoignition temperature 250 °C (482 °F)
Lethal dose or concentration LD50 Oral (Rat): > 17,000 mg/kg
LD50 (median dose) Oral LD50 (rat): >17,000 mg/kg
NIOSH PV6212500
PEL (Permissible) Not established
REL (Recommended) 50 mg/kg bw
Main hazards May cause respiratory irritation. Causes serious eye irritation. May cause skin irritation.
GHS labelling Not a hazardous substance or mixture according to the Globally Harmonized System (GHS)
Pictograms GHS07
Signal word Warning
Hazard statements No hazard statement.
Precautionary statements Keep container tightly closed. Store in a cool, dry, and well-ventilated place. Avoid contact with eyes, skin, and clothing. Wash thoroughly after handling. Do not ingest or inhale. Use personal protective equipment as required.
Flash point 131 °C
Autoignition temperature 250 °C
Lethal dose or concentration LD50 Oral Rat: > 20,000 mg/kg
LD50 (median dose) LD50 (oral, rat) >17,000 mg/kg
NIOSH WYJ07050
PEL (Permissible) Not established
REL (Recommended) 10 mg/m³
Related compounds
Related compounds Dimethyl sulfoxide (DMSO)
Methanesulfonic acid
Methylsulfonylmethane (MSM)
Sulfur
Methionine
Cysteine
Related compounds Methanesulfonic acid
Sulfolane
Methylsulfonylmethane (MSM)
Dimethyl sulfoxide (DMSO)
Dimethyl sulfate