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Material Safety Data Sheet for D-Biotin

Identification

Product Name: D-Biotin
Synonyms: Vitamin H, Coenzyme R
CAS Number: 58-85-5
Recommended Use: Nutritional supplements, laboratory reagents
Supplier Details: Contact information for manufacturer or distributor
Emergency Contact: Local emergency response number or company emergency line

Hazard Identification

Classification: Not classified as hazardous under applicable regulations
Signal Word: None
Hazard Statements: May cause slight irritation to eyes, skin, or respiratory tract if inhaled in powder form
Precautionary Statements: Avoid generating dust; wash thoroughly after handling
Other Hazards: Not a combustible material, but dust accumulation may present a nuisance risk

Composition / Information on Ingredients

Chemical Name: D-Biotin
Common Name: Biotin
Chemical Formula: C10H16N2O3S
Molecular Weight: 244.31 g/mol
Ingredient Purity: >97% D-Biotin
Impurities or Stabilizing Additives: No significant impurities at concentrations of concern

First Aid Measures

Eye Contact: Rinse eyes with plenty of water, lift eyelids occasionally; seek medical advice if irritation persists
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing
Inhalation: Move person to fresh air; if symptoms develop, get medical attention
Ingestion: Rinse mouth with water; if large amount swallowed or if symptoms develop, seek medical help
Important Symptoms: Mild irritation to skin, eyes, or respiratory tract possible, especially with excessive exposure to powder

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide
Unsuitable Extinguishing Media: High-pressure water streams may scatter dust
Special Hazards: Fine particles can form combustible dust clouds in air; no unusual thermal decomposition products
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Advice for Firefighters: Evacuate area if dust suspended in air; cool containers with water spray

Accidental Release Measures

Personal Precautions: Use personal protective equipment; avoid breathing dust; ventilate area
Environmental Precautions: Prevent runoff into drains or natural water sources; do not flush large quantities
Methods for Cleanup: Sweep or vacuum up spillage; place in labeled, closed containers; decontaminate surfaces with water
Reference to Other Sections: See handling, exposure controls, and disposal for further details

Handling and Storage

Safe Handling: Use in well-ventilated spaces; avoid creating dust; do not eat, drink, or smoke while handling
Storage Conditions: Keep container tightly closed in dry, cool, and well-ventilated place; protect from light and moisture
Incompatible Materials: Strong oxidizers may initiate reactions
Hygiene Practices: Wash hands and face after handling, remove contaminated clothing and wash before reuse

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established occupational exposure limit; minimize exposure to airborne dust
Engineering Controls: Use local exhaust ventilation or other engineering controls to keep airborne levels below recommended limits
Respiratory Protection: Wear dust mask or respirator in absence of adequate ventilation
Hand Protection: Use gloves resistant to chemicals for direct contact
Eye Protection: Safety glasses or goggles
Skin and Body Protection: Laboratory coat, protective clothing to minimize skin exposure
Environmental Exposure Controls: Avoid uncontrolled release to the environment

Physical and Chemical Properties

Appearance: White or off-white crystalline powder
Odor: Odorless
Melting Point: 232–233 °C
Boiling Point: Not applicable (decomposes)
Solubility: Slightly soluble in water, more soluble in hot water
pH: Not available
Vapor Pressure: Negligible
Density: Approximately 1.12 g/cm³
Other Data: Stable under normal conditions, decomposes at high temperature

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Not reactive under normal use
Conditions to Avoid: Excessive heat, moisture, exposure to light
Incompatible Materials: Strong oxidizing agents
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, sulfur oxides under fire conditions
Polymerization: Will not occur

Toxicological Information

Acute Toxicity: Practically non-toxic; oral LD50 (rat) > 10,000 mg/kg
Skin Contact: Non-irritant in standard animal studies
Eye Contact: Mild, reversible irritation possible
Inhalation: Dust may cause mild respiratory discomfort
Long-Term Effects: No evidence of carcinogenicity, mutagenicity, or reproductive toxicity in studies
Routes of Exposure: Primarily ingestion, inhalation of dust, skin, and eye contact

Ecological Information

Ecotoxicity: No data indicating significant hazard for aquatic or terrestrial life
Persistence and Degradability: Biodegradable under suitable environmental conditions
Bioaccumulation Potential: Low; not expected to bioaccumulate
Mobility in Soil: Dissolves slowly in water; binds to soil moderately
Other Adverse Effects: Avoid release to water systems in large amounts to prevent potential nutrient loading

Disposal Considerations

Product Disposal: Dispose of in accordance with local, national, and regional regulations
Packaging Disposal: Recycle or dispose of containers after cleaning
Unused Product: Incinerate or landfill according to local rules for non-hazardous organic chemicals
Contaminated Materials: Treat as chemical waste, use appropriate labeling

Transport Information

UN Number: Not regulated for transport
UN Proper Shipping Name: Not regulated
Transport Hazard Class: None
Packing Group: Not applicable
Special Precautions: Protect from moisture and physical damage during transit

Regulatory Information

Labeling Requirements: Not required under most global chemical regulations due to low hazard profile
Inventory Listings: Listed in TSCA (US), EINECS (EU), other major inventories
Safety, Health, Environmental Regulations: Complies with established limits as a food and feed additive; workplace exposure limits typically not assigned
Chemical Safety Assessment: Not required given usage and classification