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MSDS: Cystine

Identification

Product Name: Cystine
Chemical Formula: C6H12N2O4S2
Synonyms: 3,3′-Dithiobis(2-aminopropanoic acid), DL-Cystine
Recommended Use: Amino acid supplement, laboratory reagent, pharmaceutical manufacturing
Manufacturer Details: Refer to supplier-specific information for address and emergency contacts
CAS Number: 56-89-3
UN Number: Not classified as hazardous for transport under most international regulations
EC Number: 200-296-3
Molecular Weight: 240.30 g/mol
Emergency Phone: Provided by specific manufacturer or supplier on shipping documents
Relevant Identified Uses: Used in biochemical research, medicine, and food analysis
Restriction on Use: Not for direct human consumption without adequate processing

Hazard Identification

Classification: Typically not classified as hazardous under GHS criteria
Physical Hazards: Non-combustible, but dust formation may cause minor dust explosions if dispersed in air
Health Hazards: May cause mild irritation to eyes, skin, and respiratory tract on prolonged repeated exposure
Environmental Hazards: Not classified but spills may have effects on aquatic organisms in high concentrations
Label Elements: No symbol or signal word under standard GHS; precautionary statements should be observed
Key Symptoms: Irritation, headache, coughing, sneezing upon inhalation or direct contact
Other Hazards: Dust can create slippery surfaces and breathing difficulty in enclosed spaces
Precautionary Statements: Avoid breathing dust, wash hands after handling, keep away from food and beverages

Composition / Information on Ingredients

Cystine: >98% by weight
Chemical Formula: C6H12N2O4S2
Impurities: Trace inorganic salts or moisture (typically <1%)
Additives: None, unless specified by supplier for stability or packaging
Source: Sourced by chemical synthesis or protein hydrolysis; identity confirmed by spectral analysis
Mixture: Pure substance, not a mixture
Stabilizers: Not present in standard lab-grade samples

First Aid Measures

Inhalation: Move person to fresh air, monitor breathing, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash exposed skin thoroughly with soap and water
Eye Contact: Rinse with plenty of water for several minutes, remove contacts if present, seek doctor if irritation continues
Ingestion: Rinse mouth with water, do not induce vomiting, consult a physician if significant quantities are swallowed
Most Important Symptoms: Redness, itching, mild cough, gastrointestinal discomfort if ingested large amounts
Notes for Physicians: Treat symptomatically, provide access to medical history if allergic reactions are possible
Protection for Responders: Use protective gloves and eyewear as standard practice when assisting others

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Media: Avoid direct water jet on product due to slippery residue
Specific Hazards: Product does not burn easily, decomposition may yield sulfur oxides or nitrogen oxides under fire
Firefighting Procedures: Approach incident from upwind to avoid exposure to fumes, use PPE including breathing apparatus
Combustion Products: Sulfur dioxide, nitrogen oxides, carbon oxides
Explosion Hazard: High dust concentrations in air could cause minor explosions under severe conditions
Special Protective Equipment: Wear fire-resistant clothing, gloves, and self-contained breathing apparatus
Firefighting Guidance: Prevent runoff from entering drains, remain alert to toxic smoke

Accidental Release Measures

Personal Precautions: Ventilate area, avoid dust formation, use dust mask and protective gloves
Environmental Precautions: Prevent entry into waterways, sewers, and soil; sweep up promptly
Methods for Cleaning Up: Collect spilled material with shovel or vacuum, place in containers for disposal
Additional Precautions: Wash area with water after bulk removal, monitor for slip risk due to residue
Procedural Steps: Evacuate unnecessary personnel, mark area as hazardous, limit spread by dry containment
Waste Disposal: Follow local regulations for non-hazardous organic chemical waste

Handling and Storage

Precautions for Safe Handling: Use in well-ventilated spaces, wear gloves and eye protection, avoid generating airborne dust
Advice on General Hygiene: Do not eat, drink, or smoke near product, wash hands before breaks and after finishing job
Conditions for Safe Storage: Store in closed, labeled containers in cool, dry, and well-ventilated area
Incompatible Substances for Storage: Avoid storing near oxidizing agents, strong acids, or bases
Package Integrity: Use moisture-proof, chemically resistant containers
Control of Emissions: Use proper exhaust filtration when transferring or processing powder
Storage Temperature: Store at room temperature or refrigerated as required by manufacturer
Specific Requirements: Protect from moisture and contamination, maintain separation from foodstuffs

Exposure Controls and Personal Protection

Workplace Exposure Limits: No established occupational exposure limits for cystine, observe general dust limit (e.g., ACGIH TLV for particulates)
Engineering Controls: Use local exhaust ventilation, process enclosures, and efficient dust collection
Personal Protective Equipment: Respiratory: Dust mask or respirator during powder handling
Skin: Chemical resistant gloves
Eye: Safety glasses or goggles
Clothing: Lab coat or chemical-resistant apron
Hygiene Measures: Wash hands after handling, keep contaminated clothing separate, ensure eye wash stations available
Environmental Controls: Prevent uncontrolled release to environment by using containment procedures

Physical and Chemical Properties

Appearance: White to pale yellow crystalline powder
Odor: Nearly odorless
Melting Point: 240-250°C (decomposes)
Solubility: Slightly soluble in water, insoluble in organic solvents
Density: 1.68 g/cm³
pH (1% Solution): Approximately 5-6
Boiling Point: Decomposes before boiling point is reached
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Kow): -2.49
Evaporation Rate: Not applicable
Flammability: Non-flammable solid
Flash Point: Not applicable
Auto-ignition Temperature: Not auto-ignitable under normal conditions
Explosive Properties: Dust could form explosive mixtures with air at high concentrations
Oxidizing Properties: Not classified as an oxidizer

Stability and Reactivity

Chemical Stability: Stable under normal storage and handling conditions
Reactivity: Not reactive with most substances at ambient conditions
Conditions to Avoid: Exposure to moisture, high temperatures, open flames, and strong oxidizers
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition Products: Sulfur oxides, carbon oxides, nitrogen oxides on combustion or decomposition
Polymerization: Not known to occur
Sensitivity to Static Discharge: Fine dust may be sensitive under very dry conditions
Corrosivity: Not corrosive, but prolonged exposure may affect susceptible metals or surfaces due to sulfur content

Toxicological Information

Acute Toxicity: Low toxicity, high doses may cause headache, nausea, gastrointestinal upset
Skin Contact: Irritation or redness possible with repeated or prolonged contact
Eye Contact: Mild irritation, tearing, redness
Inhalation: Dust causes irritation to respiratory tract, coughing, sneezing
Ingestion: Vomiting, diarrhea at large intakes, low risk at typical levels used in labs
Chronic Effects: Not classified as carcinogenic, mutagenic, or toxic for reproduction in known studies
Allergic Sensitization: Rare risk, but possible in sensitive individuals
LD50 (Oral, Rat): More than 8000 mg/kg, considered non-toxic based on lab studies
Other Health Effects: Not expected to be systemically hazardous in occupational settings

Ecological Information

Ecotoxicity: Not expected to have significant harmful effect at low concentrations; excessive release could affect aquatic organisms
Persistence and Degradability: Readily biodegradable, breaks down in environment with typical conditions
Bioaccumulation Potential: Not expected to bioaccumulate in organisms due to chemical structure
Mobility in Soil: Low, binds well to organic matter and is degraded by microorganisms
Other Adverse Effects: No significant ozone depletion, photochemical smog, or other systemic environmental impacts documented
Aquatic Toxicity: No significant acute or chronic toxicity for most aquatic species reported

Disposal Considerations

Waste Treatment Methods: Collect solid waste, avoid dispersing dust, follow approved chemical disposal protocols
Disposal of Packaging: Rinse containers to remove residue, dispose of in accordance with national/local rules as non-hazardous chemical containers
Physical/Chemical Properties for Disposal: Stable for landfill, incineration may produce sulfur oxides
Special Precautions: Avoid releasing large amounts into environment or sewer systems
Disposal Guidance: Use licensed waste disposal contractor familiar with laboratory chemicals

Transport Information

UN Number: Not regulated as dangerous goods under UN, ADR, IMDG, or IATA rules
Proper Shipping Name: Cystine
Transport Hazard Class: Not classified
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Special Precautions for Transport: Use strong, sealed containers, protect from moisture during transport
Transport in Bulk: Not subject to bulk transport regulations
Additional Transport Information: Follow national regulations for labeling and cargo security

Regulatory Information

OSHA Status (US): Not regulated as a hazardous chemical
EPA TSCA Status: Listed on Chemical Substance Inventory
EU REACH Registration: Exempt as a naturally occurring substance, listed on EINECS inventory
Labeling Requirements: None mandated for cystine by GHS, observe good laboratory safety practice
Other International Regulations: Not controlled under UN, IATA, IMDG guidelines
DSL/NDSL (Canada): Listed
SARA Title III: Not subject to reporting under SARA, CERCLA or RCRA in United States
Workplace Use: Maintain Safety Data Sheet accessible to staff, provide training and PPE as per internal protocols
Other Regulations: National or state-specific requirements may exist for occupational exposure and waste handling