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Material Safety Data Sheet: Cysteamine Hydrochloride

Identification

Product Name: Cysteamine Hydrochloride
Synonyms: 2-Aminoethanethiol hydrochloride, β-Mercaptoethylamine hydrochloride
CAS Number: 156-57-0
Recommended Uses: Active pharmaceutical ingredient, research chemical, intermediate in chemical synthesis
Manufacturer Details: Refer to product supplier’s information for complete contact and emergency phone number
Emergency Overview: White crystalline powder, notable odor similar to rotten eggs, used in laboratory and industrial processes

Hazard Identification

GHS Classification: Acute Toxicity (Oral and Dermal), Eye Irritation, Skin Sensitization
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may cause respiratory irritation, may cause allergic skin reaction
Pictograms: Exclamation mark (irritant), health hazard symbols
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, wear protective gloves, eye and face protection, use only in well-ventilated areas

Composition / Information on Ingredients

Chemical Name: Cysteamine Hydrochloride
Chemical Formula: C2H7NS.HCl
Molecular Weight: 113.62 g/mol
Concentration: 100% as supplied, unless diluted or mixed
Impurities: Low level process-related impurities might occur in technical grades; refer to CoA for details

First Aid Measures

Eye Contact: Immediately flush with plenty of water for fifteen minutes, lift eyelids occasionally, seek medical attention urgently
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, contact a healthcare provider if irritation develops
Inhalation: Move exposed person to fresh air, monitor for respiratory distress, seek emergency help if symptoms persist
Ingestion: Rinse mouth thoroughly, do not induce vomiting, get immediate medical help and show label if possible
Notes for Physician: Treat symptomatically and supportively, monitor for respiratory and allergic reactions

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide as appropriate
Unsuitable Extinguishing Media: Direct stream of water may scatter material
Specific Hazards: Decomposition releases toxic and corrosive gases such as hydrogen chloride, sulfur oxides, nitrogen oxides
Protective Equipment for Firefighters: Full protective gear and self-contained breathing apparatus required
Advice: Approach from upwind, prevent runoff from entering water supplies and sewers

Accidental Release Measures

Personal Precautions: Use personal protective equipment including gloves, goggles, and appropriate clothing, keep unprotected persons away
Environmental Precautions: Prevent further leakage or spillage, avoid discharge to drains, surface and ground water
Methods for Clean-up: Sweep up without raising dust, place in a suitable container for disposal, ventilate area, wash spill site after material pick-up
Decontamination: Use water and detergents, do not use bleach or oxidizers directly on the spill

Handling and Storage

Advice on Safe Handling: Avoid contact with skin, eyes, and clothing, avoid inhaling dust or fumes, work in well-ventilated area, use local exhaust
Hygiene Measures: Wash hands after handling, do not eat, drink or smoke in the work area, launder contaminated clothing before reuse
Storage Requirements: Keep container tightly closed, store in dry, cool, well-ventilated area, keep away from oxidizers, acids, and heat sources
Incompatibilities: Strong oxidizing agents, strong acids, alkali metals, peroxides

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established OSHA or ACGIH limits, handle as hazardous material
Engineering Controls: Use fume hood, provide local exhaust ventilation to minimize exposure
Personal Protective Equipment: Chemical-resistant gloves, safety goggles, lab coat or chemical apron, suitable respirator if dust forms
Environmental Controls: Minimize release to air and water, ensure proper ventilation and spill containment

Physical and Chemical Properties

Physical State: Solid
Appearance: White to off-white crystalline powder
Odor: Strong, unpleasant, mercaptan-like
Melting Point: 61–67°C
Boiling Point: Not applicable (decomposes)
Solubility: Highly soluble in water, slightly soluble in ethanol
pH (solution): 4 to 5 (in 10% aqueous solution)
Vapor Pressure: Negligible at room temperature
Partition Coefficient: Not readily available
Other Properties: Stable under recommended storage conditions, emits strong odor if exposed to heat or moisture

Stability and Reactivity

Chemical Stability: Stable under normal storage and handling, sensitive to moisture
Conditions to Avoid: Exposure to flames, heat, strong oxidizers, prolonged exposure to air
Incompatible Materials: Oxidizing agents, acids, metals, reducing agents
Hazardous Decomposition Products: Hydrogen chloride, sulfur oxides, ammonia, nitrogen oxides, volatile organic compounds

Toxicological Information

Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Acute Effects: Gastrointestinal symptoms if swallowed, irritation and redness of eyes and skin, possible allergic reaction
Chronic Effects: Prolonged exposure may cause dermatitis, asthma-like symptoms, or other sensitization
Toxicity Data: Oral LD50 (rat): ~650 mg/kg; skin absorption and inhalation toxicity less defined
Other Information: Not listed as carcinogenic by IARC, NTP, OSHA, or ACGIH, but can aggravate existing allergies or asthma

Ecological Information

Ecotoxicity: Data limited; avoid uncontrolled release, potential risks to aquatic species based on chemical structure
Persistence and Degradability: Expected to degrade in environment but actual breakdown rates may vary
Bioaccumulative Potential: Not expected to bioaccumulate significantly
Mobility in Soil: Soluble, can migrate in water systems if not contained
Other Adverse Effects: Minimize entry into lakes, rivers, waterways; consult local guidelines for action if large release occurs

Disposal Considerations

Product Disposal: Incinerate under controlled conditions or follow local, regional, and national regulations; never pour down the drain
Contaminated Packaging: Dispose of as hazardous waste after decontamination, do not reuse containers
Special Instructions: Seek advice of licensed chemical waste disposal contractor, follow site-specific safety protocols at all times

Transport Information

UN Number: Not classified as a dangerous good for transport
Proper Shipping Name: Cysteamine Hydrochloride
Transport Hazard Class: Non-hazardous according to current international rules. Check country-specific regulations
Packing Group: Not applicable
Special Precautions: Minimize risk of spills, secure packaging during transport, inform carriers of chemical nature if quantities are large

Regulatory Information

TSCA Status: Listed
REACH Registration: Check import volume, consult European Chemical Authority for status
SARA 313: Not subject to reporting
California Proposition 65: Not listed
Other Regulations: Review current national and local safety and environmental regulations before manufacturing, using, or disposing, maintain accessible records of purchases and end-use