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Product Name: Cyanocobalamin
Synonyms: Vitamin B12, 5,6-Dimethylbenzimidazolyl cyanocobamide, CNCbl
CAS Number: 68-19-9
Molecular Formula: C63H88CoN14O14P
Recommended Use: Dietary supplement, pharmaceutical ingredient, laboratory reagent
Supplier: Pharmaceutical manufacturers, chemical suppliers
Contact Information: Refer to supplier-specific documentation for emergency numbers and addresses
Emergency Overview: Reddish crystalline powder or solid with no significant odor; not intended for direct contact beyond recommended industrial uses
Classification: Not classified as hazardous based on Globally Harmonized System (GHS) criteria
Potential Health Effects: May cause skin, eye, and respiratory tract irritation on exposure; large amounts through injection or inhalation may cause allergic reaction or systemic symptoms in sensitive people
Chronic Exposure Risks: No known chronic health effects in typical handling situations, though rare hypersensitivity reactions may occur
Special Hazards: Dust may cause mild mechanical irritation
Label Elements: No pictogram required; precautionary statements encourage avoiding prolonged or repeated direct contact
Cyanocobalamin: 98-100%
Impurities: Trace amounts of related analogues, water (moisture), excipients by specific formulation
Other Ingredients: None generally present unless formulated with additives for tablets, capsules, or injectables by finished product specifications
Inhalation: Move person to fresh air, support breathing as needed, seek medical attention if symptoms develop
Skin Contact: Remove contaminated clothing, wash affected area thoroughly with soap and water, consult a doctor if irritation persists
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek medical advice in case of sustained irritation
Ingestion: Rinse mouth, do not induce vomiting, seek medical advice especially for large quantities or if symptoms occur
Notes for Doctors: Treat symptomatically, manage allergic or anaphylactic responses with appropriate protocols
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Specific Hazards: Material itself does not support combustion, but thermal decomposition or fire in surrounding area may release toxic fumes such as nitrogen oxides, carbon oxides, cobalt compounds, hydrogen cyanide
Protective Equipment: Use positive pressure self-contained breathing apparatus and full protective gear when fighting chemical fires
Firefighting Advice: Move containers from fire area if possible and safe; use water spray to cool exposed surfaces; avoid breathing dust, fumes, or smoke from decomposition
Personal Precautions: Wear approved protective clothing, gloves, goggles, and a dust mask or respirator; avoid generating dust
Environmental Precautions: Prevent uncontrolled entry into drains, waterways, or soil; contain and recover spill for disposal according to regulatory guidelines
Cleanup Methods: Sweep or vacuum up material carefully without generating dust, place in labeled, tightly sealed container for prompt disposal or reprocessing, ventilate area, wash spillage area with water if necessary
Handling: Avoid creating or breathing dust; handle with adequate ventilation; minimize direct contact with skin or eyes; practice good hygiene and wash hands after use
Storage Conditions: Store in tightly closed container in a cool, dry location away from direct sunlight, moisture, and incompatible materials such as strong oxidizers or acids
Incompatibilities: Strong oxidizing agents, strong acids, exposure to light and heat may degrade product
Special Requirements: Secure storage to keep out of reach of unauthorized personnel and incompatibles
Engineering Controls: Provide local exhaust or general ventilation to minimize airborne concentrations
Respiratory Protection: Use NIOSH-approved respirators if dust concentration exceeds occupational exposure limits or during clean-up of large spills
Skin Protection: Wear chemical-resistant gloves and lab coat or work clothing; minimize skin exposure
Eye Protection: Use safety glasses or goggles with side shields
Occupational Exposure Limits: No specific exposure limits established for cyanocobalamin; follow general guidelines for nuisance dusts
Hygiene Measures: Wash hands after handling, avoid eating or drinking in work area, remove and wash contaminated clothing before reuse
Appearance: Crystalline red powder or solid
Odor: Odorless or nearly odorless
Odor Threshold: Not applicable
pH (1% solution): 4.0 to 7.0
Solubility: Soluble in water, practically insoluble in chloroform, acetone, and ether
Melting Point: Decomposes above 230°C, does not have a precise melting point
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not available
Relative Density: Approximately 1.4 to 1.5 g/cm³
Vapor Pressure: Not applicable
Partition Coefficient (octanol/water): Not determined
Evaporation Rate: Not applicable
Viscosity: Not applicable
Form: Powder, crystalline
Chemical Stability: Stable under recommended storage conditions and normal temperatures
Reactivity: Not reactive under normal handling and storage
Hazardous Reactions: No dangerous reactions known under proper use; avoid strong oxidants, acids, and exposure to extreme heat, light, or moisture
Decomposition Products: May release carbon oxides, nitrogen oxides, hydrogen cyanide, and cobalt oxides on thermal decomposition
Polymerization: Not known to polymerize
Acute Toxicity: Oral LD50 in rats greater than 2000 mg/kg, indicating very low toxicity; not acutely toxic by dermal or inhalation routes in studies
Skin Irritation: Few reports of mild irritation in susceptible individuals; generally not considered a skin irritant
Eye Irritation: May cause transient irritation
Inhalation: Limited data, likely to cause minor irritation only with significant dust exposure
Chronic Toxicity: Not classified for chronic toxicity; vitamin B12 is widely used in nutritional supplements, no evidence of carcinogenicity or teratogenicity in humans from normal exposure levels
Sensitization: Rare cutaneous or systemic allergic responses reported in sensitive individuals
Other Effects: High doses may cause acneiform eruptions or rosacea-like dermatitis in rare cases; no evidence of reproductive toxicity in animal studies
Ecotoxicity: No evidence of acute environmental hazard; low toxicity to aquatic life based on available data
Persistence and Degradability: Expected to be biodegradable under environmental conditions, with breakdown into inorganic components
Bioaccumulative Potential: Not expected to bioaccumulate due to high water solubility and metabolic degradation
Mobility in Soil: Readily mobile in water, not likely to persist in sediment or soil
Other Adverse Effects: Large-scale untreated spills may cause localized changes in biochemical oxygen demand (BOD)
Waste Disposal: Dispose of unused material, contaminated sweepings, packaging, and washings in accordance with local, regional, and national regulations for laboratory chemicals, pharmaceuticals, or vitamins
Incineration: Suitable for high-temperature incineration with flue-gas scrubbing for controlling release of hazardous decomposition products
Do Not: Discharge to waterways, storm drains, or soil
Container Disposal: Rinse empty containers before recycling or landfilling as non-hazardous unless contaminated
UN Number: Not regulated for transport under United Nations, US DOT, IATA, or IMDG codes
Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions: Avoid simultaneous transport with incompatible substances or food products, maintain secure packaging, protect from physical damage and environmental extremes
Label Requirements: No hazardous labels required
Inventory Status: Listed under TSCA, EINECS, DSL, AICS, ENCS, and other regulatory chemical inventories
OSHA Status: Not considered hazardous under US OSHA Hazard Communication Standard
SARA Title III: Not listed as hazardous under Sections 302, 304, 313
California Proposition 65: Not listed as a carcinogen or reproductive toxin
Other Regulatory Information: Subject to standard chemical hygiene and occupational health requirements for laboratory and manufacturing workplaces; not subject to special restrictions on distribution or use for most jurisdictions
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
