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Material Safety Data Sheet: Creatine Anhydrous

Identification

Product Name: Creatine Anhydrous
Chemical Name: Methylguanidoacetic acid
SYNONYMS: N-(Aminoiminomethyl)-N-methyl glycine
CAS Number: 57-00-1
Recommended Uses: Nutraceutical, dietary supplement, research laboratory
Supplier: Manufacturer or distributor contact details according to packaging label
Emergency Contact: Emergency phone number located on product container, local poison control for immediate assistance

Hazard Identification

GHS Classification: Not classified as hazardous under GHS
Signal Word: None
Pictograms: None assigned
Hazard Statements: Product is considered of low acute toxicity; may cause minor irritation through eye or skin contact in sensitive individuals; dust generation may cause mild respiratory irritation
Precautionary Statements: Avoid direct inhalation of powders, prevent contact with eyes, do not eat or drink during handling
Other Hazards: May form combustible dust concentrations in air under certain handling conditions, keep away from ignition sources

Composition / Information on Ingredients

Chemical Identity: Creatine Anhydrous
CAS Number: 57-00-1
Purity: Typically >99% by weight
Other Ingredients: None intentionally added
Impurities: Trace amounts of related compounds possible, dependent on manufacturing process; not expected to pose a safety risk if used as intended

First Aid Measures

Inhalation: Move person to fresh air, seek medical advice if symptoms such as cough or shortness of breath develop
Skin Contact: Wash affected area with soap and plenty of water, seek medical attention if skin irritation persists
Eye Contact: Rinse eyes thoroughly with clean water for at least fifteen minutes, remove contact lenses, seek medical attention if irritation or discomfort continues
Ingestion: Rinse mouth with water, consult physician if large volume consumed or for persistent abdominal symptoms
Most Important Symptoms: Mild irritation or discomfort at sites of exposure, no specific systemic effects known
Notes to Physician: Treat symptomatically, no sudden systemic hazard expected under common workplace exposures

Fire-Fighting Measures

Suitable Extinguishing Media: Use dry chemical, carbon dioxide, water spray, or foam
Unsuitable Media: Do not use high pressure water streams which may cause powder to become airborne
Fire Hazards: Organic powders can present dust explosion risk in air; product itself is not highly flammable
Special Protective Equipment: Firefighters should wear full protective gear and self-contained breathing apparatus
Hazardous Combustion Products: Incomplete burning may produce carbon oxides, nitrogen oxides; ventilate area after fire
Instructions for Firefighters: Avoid inhaling smoke, prevent run-off from entering drains or watercourses

Accidental Release Measures

Personal Precautions: Evacuate area if dust becomes excessive, avoid contact with eyes and skin, use appropriate personal protective equipment such as gloves and dust mask
Environmental Precautions: Prevent powder from entering drains or surface waters, sweep up to avoid spread
Methods for Cleanup: Sweep or vacuum up spilled material, avoid raising dust, place recovered product into suitable closed containers for disposal, flush spill area with water if permitted
Reference to Other Sections: Use information on handling, exposure controls, and disposal for proper spill response

Handling and Storage

Precautions for Safe Handling: Minimize dust generation, handle with care to avoid spills, wash hands after use, avoid eating or drinking in processing areas, keep container tightly closed when not in use
Storage Conditions: Store in cool, dry, well-ventilated place away from strong acids, alkalis, and oxidizers; avoid heat, sparks, or open flame
Packaging Materials: Use original or compatible sealed packaging; do not transfer to unlabeled containers
Specific End Uses: Refer to product labeling for recommended use and storage practices; lab or supplement use only

Exposure Controls and Personal Protection

Occupational Exposure Limits: No specific exposure limits set for creatine anhydrous; maintain airborne dust levels as low as possible
Engineering Controls: Use local exhaust or general dilution ventilation to limit workplace dust concentrations
Personal Protective Equipment: Wear protective gloves, use safety glasses or goggles for eye protection, if dust is present use dust mask (P2 or N95 rated), wear protective clothing if risk of skin contact
Hygiene Measures: Wash hands after handling, remove contaminated clothing and protective equipment before eating or leaving work area

Physical and Chemical Properties

Appearance: White crystalline powder
Odor: Odorless
pH: Approximate 7 in aqueous solution
Melting Point: Above 292°C (decomposes)
Boiling Point: Not available
Solubility: Slightly soluble in water
Vapor Pressure: Not applicable
Partition Coefficient (log Kow): Not determined
Density: 1.34 g/cm³
Flash Point: Not applicable
Flammability: Not classified as flammable, but powdered form may contribute to dust hazards

Stability and Reactivity

Chemical Stability: Stable under recommended conditions of use and storage
Hazardous Reactions: No dangerous reactions expected with common substances under normal use
Conditions to Avoid: Excessive heat, sources of ignition, accumulation of dust in air
Incompatible Materials: Strong oxidizing agents, strong acids
Hazardous Decomposition Products: Under fire or decomposition, may emit toxic gases including carbon monoxide, nitrogen oxides

Toxicological Information

Acute Toxicity: Low oral toxicity; large single doses may cause mild gastrointestinal discomfort
Chronic Effects: Repeated oral exposure in recommended amounts not linked with adverse effects in scientific literature
Skin Irritation: Not expected with typical use, rare skin sensitization reported
Eye Irritation: Contact may cause minor mechanical irritation
Respiratory Effects: Prolonged inhalation of dust can irritate airways
Mutagenicity, Carcinogenicity, Reproductive Toxicity: Not classified; existing evidence supports low concern for these endpoints at workplace exposures
Reference to Data: See peer-reviewed sources such as the National Institutes of Health (NIH) and peer-reviewed toxicology reports

Ecological Information

Aquatic Toxicity: Low toxicity based on available data, not expected to bioaccumulate significantly in aquatic organisms
Mobility: Slight solubility in water indicates potential for migration in soil and water, but rapid biodegradation likely
Persistence and Degradability: Expected to degrade readily in environment through natural processes
Bioaccumulation: Not likely to concentrate in organisms from environmental exposure
Other Ecological Effects: Low overall environmental impact based on current usage and studies

Disposal Considerations

Disposal Methods: Dispose of in accordance with local, state, and federal regulations; product can be sent to landfill or incineration after confirming with relevant authority
Hazardous Waste: Not classified as hazardous waste under most jurisdictions
Container Disposal: Empty containers can be recycled or discarded as local regulations require; avoid uncontrolled dumping in environment
Contaminated Packaging: Rinse and recycle or dispose of safely

Transport Information

UN Number: Not regulated for transport
Transport Hazard Class: Not classified as hazardous
Packing Group: Not applicable
Special Precautions: Keep containers secure to prevent dust release or moisture exposure
Transport Labeling: No special markings required
Bulk Transportation: Follow good industrial hygiene and transport practices; minimize dust emission during loading/unloading

Regulatory Information

Regulatory Status: Product not subject to specific chemical regulatory reporting in major markets; regarded as a nutraceutical or dietary ingredient
Labelling Requirements: Must comply with food and supplement labeling laws where sold for human consumption
TSCA Inventory: Listed
REACH Registration: Meets requirements for substances used in food or food supplements in Europe
Other Relevant Regulations: Occupational exposure monitoring may be required if handled in bulk, local workplace safety regulations apply
Workplace Controls: Employers maintain Safety Data Sheets and provide employee training per OSHA Hazard Communication Standard or regional equivalent