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Product name: Collagen
Chemical name: Collagen, hydrolyzed collagen
Synonyms: Gelatin, hydrolyzed gelatin
CAS Number: 9007-34-5
Recommended use: Skin-care formulations, supplements, biomedical materials
Manufacturer contact: [Contact information as found on actual supplier package]
Emergency contact information: [Supplier emergency line provided on shipment documents]
Classification: Collagen does not classify under hazardous categories in accordance with GHS
Signal word: None
GHS pictograms: None
Hazard statements: Not regarded as flammable, toxic, or corrosive
Precautionary statements: Minimize inhalation of dust and avoid direct eye contact; keep away from ignition sources when in powdered form
Ingredient: Collagen (Type I, bovine or porcine source)
Percent purity: 90%-98%
Impurities: Trace mineral salts, water content (up to 10%), possible presence of glycine and proline peptides as breakdown products
Other components: None expected above 1% threshold
Inhalation: Move person outdoors, provide fresh air, monitor for persistent coughing or throat irritation
Skin contact: Wash thoroughly using soap and water, remove contaminated clothing if irritation develops
Eye contact: Rinse carefully with plenty of water for 10-15 minutes, remove contact lenses if present, seek eye examination for persistent discomfort
Ingestion: Rinse mouth with water; collagen is low hazard but seek attention for prolonged gastrointestinal symptoms
Advice to physician: Treat based on symptoms, no specific antidote, monitor allergic responses
Suitable extinguishing media: Foam, dry chemical, water spray, or carbon dioxide
Unsuitable extinguishing media: Direct water jet may scatter dust
Specific hazards: Combustion yields carbon monoxide, carbon dioxide, nitrogen oxides
Protective equipment: Firefighters should use self-contained breathing apparatus and full protective gear
Explosion hazard: Fine powder can form explosive dust-air mixtures in confined spaces
Advice: Cool surrounding containers, prevent firewater from contaminating environment
Personal precautions: Evacuate area for large spills, ventilate; use mask or respirator in dust-rich environments
Protective equipment: Gloves, goggles, dust mask recommended
Environmental precautions: Prevent entry into drains or natural waterways; sweep up spilled powder
Spill response: Avoid generating dust, use dampened absorbent materials, collect in labeled waste container, wash contaminated area thoroughly
Safe handling: Avoid breathing dust, minimize contact with eyes and skin, clean work area regularly
Technical measures: Use local exhaust ventilation if making or processing large volumes
Storage requirements: Store in tightly-closed containers in a cool, dry, well-ventilated area; shield from sunlight and moisture
Incompatible materials: Strong oxidizers, strong acids
Special notes: Keep away from food and beverages to avoid accidental ingestion
Exposure limits: No specific OSHA or ACGIH exposure limits assigned for collagen; treat as nuisance dust, 10 mg/m3 total dust limit recommended
Engineering controls: Local exhaust ventilation and/or dust collection for bulk handling
Personal protection: Gloves, lab coat or apron, safety glasses or goggles, dust mask for airborne particulates
Hygiene measures: Wash hands after handling, do not eat or drink in processing areas
Environmental controls: Prevent product from entering drains and natural waterways
Appearance: Off-white to light yellow powder or granules
Odor: Faint, characteristic protein smell
Odor threshold: Not determined
pH: Neutral (for 6.67% solution: 6–7.5)
Melting point/freezing point: Decomposes before melting
Initial boiling point: Not applicable
Flash point: Not determined
Evaporation rate: Not volatile
Flammability: Dust may ignite above 400°C
Explosive limits: Not determined, dust suspension risk
Vapor pressure: Not applicable
Solubility: Partially soluble in cold water, fully soluble in hot water
Partition coefficient: Not determined
Auto-ignition temperature: 450–500°C
Decomposition temperature: 180–200°C
Viscosity: Forms viscous solution in water
Molecular weight: Ranges widely, typically 50,000–300,000 Da
Chemical stability: Stable under typical storage and handling conditions
Reactivity: Not reactive with common substances under ambient conditions
Conditions to avoid: Sources of intense heat, sparks, open flames, strong acids or bases
Incompatible materials: Strong oxidizers, strong reducing agents
Hazardous decomposition products: Combustion produces carbon monoxide, carbon dioxide, nitrogen compounds
Polymerization: Will not occur spontaneously
Acute toxicity: Low toxicity by ingestion, inhalation, and dermal routes; typical LD50 values above 5,000 mg/kg oral (rat)
Chronic exposure: No known adverse health effects from prolonged or repeated use in approved food and cosmetic applications
Skin irritation: Rare, mild irritation may occur on sensitive skin
Eye irritation: Can cause discomfort or irritation
Sensitization: Rare reports of allergic reactions among sensitive individuals
Carcinogenicity: Not classified as carcinogenic by WHO, IARC, NTP, or OSHA
Mutagenicity: No known mutagenicity
Reproduction toxicity: No known effects on reproduction based on available data
Other health effects: Inhalation of large dust quantities can cause respiratory discomfort
Ecotoxicity: No acute or chronic hazard to aquatic life identified; biodegradable protein-based substance
Persistence and degradability: Readily broken down by microorganisms over days to weeks
Bioaccumulation potential: Does not bioaccumulate in organisms
Mobility in soil: Dissolves and disperses in water, binds to organic matter in soil
Other adverse effects: Large spills may increase nutrient load in water, promoting algal growth
Product: Collect and dispose as non-hazardous waste in approved landfill or by composting; comply with local regulations
Contaminated packaging: Clean for recycling or dispose alongside product
Special instructions: Avoid disposal in natural waterways, prevent excessive dust from entering air
UN Number: Not regulated
Proper shipping name: Not hazardous for transport
Shipping class: Not regulated
Packing group: Not assigned
Environmental hazards: None as transported
Transport label requirements: No special markings required
OSHA status: Not classified as hazardous under US hazard communication rules
TSCA inventory: Listed
REACH registration: Not required for natural origin products in many cases
DSL/NDSL (Canada): Listed
FDA: Recognized as GRAS (Generally Recognized as Safe) for food and supplement uses in the USA
SARA 313: Not listed
California Prop 65: Not listed as a chemical known to cause cancer or reproductive harm
WHMIS status: Non-controlled product
Other regulations: Subject to local regulation when handled in food, cosmetic, or biomedical manufacturing
