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Material Safety Data Sheet for Co-Enzyme Q10

Identification

Product Name: Co-Enzyme Q10
Chemical Name: Ubiquinone-10
Synonyms: CoQ10, Ubidecarenone
CAS Number: 303-98-0
Recommended Uses: Dietary supplement, pharmaceutical ingredient, cosmetic additive
Supplier Details: Manufacturers commonly provide company name, address, and emergency contact number for rapid response during incidents.

Hazard Identification

GHS Classification: Not classified as hazardous under GHS criteria
Signal Word: None
Hazard Statements: Substance typically presents low acute toxicity, little risk of irritation or sensitization. Obvious hazards such as flammability and dust formation may be relevant in bulk handling.
Precautionary Statements: Use recommended safeguards for dust inhalation, possible combustible risk in powder form, and eye protection.

Composition / Information on Ingredients

Chemical Identity: Ubiquinone-10 (C59H90O4)
Purity: Usually provided at over 98% pure for supplements or pharmaceuticals
Impurities: Trace residual solvents or related quinone impurities, generally present at very low concentrations
Physical Form: Bright yellow to orange crystalline powder
Concentration: Commercial lots range from pharmaceutical-grade 10-100%.

First Aid Measures

Inhalation: Remove to fresh air, monitor for respiratory discomfort, medical advice if symptoms persist
Skin Contact: Wash off with soap and water, medical attention for persistent irritation
Eye Contact: Rinse immediately with plenty of water, seek medical help if discomfort remains
Ingestion: Rinse mouth, drink water if conscious, medical attention as a precaution
Note for Physicians: Treat symptomatically; no specific antidote known.

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, CO2, dry chemical powder, foam
Specific Hazards: Combustible dust hazard, may form dust clouds which ignite
Hazardous Combustion Products: Carbon oxides (CO, CO2) released during fire
Personal Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective gear
Advice: Remove containers from fire area if safe, avoid inhalation of smoke and fumes.

Accidental Release Measures

Personal Precautions: Avoid dust formation, use local ventilation, wear protective gloves and goggles
Environmental Precautions: Prevent runoff to drains or environment
Cleanup Methods: Collect gently, scoop up without raising dust, store in appropriate waste container
Disposal: Dispose of contaminated materials according to local, regional, and national guidelines
Notes: Sweep spills with non-sparking tools on anti-static mats; minimize airborne particles.

Handling and Storage

Precautions for Safe Handling: Ground containers, minimize dust generation, wash hands before eating
Conditions for Safe Storage: Keep in tightly sealed containers, cool, well-ventilated spots away from ignition sources
Incompatible Materials: Keep away from oxidizers, strong acids and bases
Special Considerations: Avoid excessive heat, sunlight, and moisture which may degrade compound
Storage Class: Often stored with other non-hazardous organic compounds, pharmaceutical excipients.

Exposure Controls and Personal Protection

Occupational Exposure Limits: Not established for CoQ10, control dust using best practices
Engineering Controls: Use local exhaust ventilation to minimize airborne concentrations
Personal Protective Equipment: Safety glasses with side shields, protective gloves, suitable dust mask or respirator for bulk handling
Hygiene Measures: Wash hands and equipment after use, avoid eating or smoking in work areas
Environmental Controls: Implement routine checks of waste and air filtration systems to limit environmental release.

Physical and Chemical Properties

Appearance: Yellow to orange crystalline powder
Odor: Odorless, sometimes almost neutral in scent
Odor Threshold: Not detectable or relevant
pH: Insoluble in water, typically not applicable
Melting Point: About 48-52°C
Boiling Point: Decomposes before boiling
Flash Point: Over 113°C (closed cup)
Flammability: Combustible in fine dust
Solubility: Insoluble in water, soluble in organic solvents like ethanol, oils
Partition Coefficient (log Pow): High lipophilicity, around 20
Vapor Pressure: Negligible under ambient conditions
Relative Density: Approx. 1.0-1.1 (water = 1)
Explosive Properties: Dust explosion risk exists with airborne powder
Other Data: Moisture sensitive, degrades in strong light or heat.

Stability and Reactivity

Chemical Stability: Stable under recommended handling and storage
Conditions to Avoid: Extended exposure to heat, light, and air
Incompatible Materials: Strong oxidizing agents, acids, and bases
Hazardous Decomposition Products: Breakdown produces carbon oxides, particularly during burning
Possibility of Hazardous Reactions: No dangerous reactions known under normal conditions; avoid creating dust clouds.

Toxicological Information

Acute Toxicity: Low oral toxicity; LD50 in rats typically over 4000 mg/kg
Skin Corrosion/Irritation: Not classified as irritant
Serious Eye Damage/Irritation: No evidence of human or animal eye damage from accidental exposure
Respiratory/Skin Sensitization: Rare, but may cause mild irritation in sensitive individuals
Chronic Exposure: Evidence from supplement studies points to good tolerability, no evidence for carcinogenicity, mutagenicity, or reproductive toxicity at standard doses
Other Health Effects: Most human studies focus on benefits, but manufacturing and handling powders in bulk can cause mechanical irritation.

Ecological Information

Ecotoxicity: Detected low aquatic toxicity, not bioaccumulative in standard concentration exposures
Persistence and Degradability: Degrades slowly in environment, breaks down with sunlight and microbial activity
Bioaccumulation Potential: Highly lipophilic but not shown to build up significantly in environmental studies
Mobility in Soil: Strongly binds to soils, unlikely to contaminate groundwater significantly
Other Adverse Effects: Not expected to be harmful to wildlife or aquatic organisms based on research and analog data.

Disposal Considerations

Waste Treatment Methods: Dispose according to local regulations, incineration or controlled landfill for bulk waste
Packaging Disposal: Triple rinse and recycle containers where possible, hazardous waste procedures if contaminated
Contaminated Materials: Handle as chemical waste, use labeled and sealed waste bins
Water Disposal: Avoid disposal in drains or natural water sources
Advice: Engage certified chemical disposal vendors, keep up-to-date on regional guidelines to prevent environmental release.

Transport Information

UN Number: Not classified as a hazardous material for transport
UN Proper Shipping Name: None required
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Marine Pollutant: Not considered a marine pollutant
Special Precautions: Use sealed containers, label as non-hazardous, ship protected from heat and moisture, prevent spillage.

Regulatory Information

Safety, Health, and Environmental Regulations: Listed under dietary supplement and pharmaceutical ingredient standards in many countries
Regulatory Status: Not classified as a hazardous material under US OSHA, EU REACH, or Canadian WHMIS
Labeling Requirements: Standard chemical labeling, precautionary and hazard statements as per local law
Chemical Inventory Listing: Present on US TSCA, Canadian DSL, EU EINECS/ELINCS, and other country inventories
Consumer Product Restrictions: Subject to quality and purity standards under food and drug statutes, labeling for end-use required by agencies such as US FDA, EFSA, or Health Canada.