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Product Name: Clostridium butyricum
Chemical Family: Bacterial culture
Recommended Uses: Microbial food additive, probiotic supplement, agricultural microbial inoculant, research laboratory culture
Supplier Details: Contact information for manufacturer or distributor (phone, address, email required on original document)
Emergency Contact: Refer to 24-hour emergency telephone number provided by supplier
SDS Number: Specific number from manufacturer documentation
Date Issued: Latest revision date, should be present for tracking updates
Classification: Biological material, typically not hazardous in routine handling for trained personnel. Not classified as hazardous according to GHS criteria, as C. butyricum is non-toxic and used in human and animal applications.
Primary Hazards: Potential cause of mild eye, skin, or respiratory irritation in susceptible individuals; risk of allergic response in some users;
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Label Elements: No standard pictogram required; cautionary statements for sensitive individuals;
Other Hazards: Not genetically modified—environmental risk minimal with standard lab/industrial protocols
Signal Word: Not applicable
Ingredient: Live Clostridium butyricum bacteria, commonly strain specific (e.g., CGMCC0313-1, MIYAIRI 588, DSM 10702)
Concentration: Ranges up to 1 x 109 CFU/g in commercial powders and liquids
Chemical Formula: Not applicable—living microorganism
Impurities: Typical growth medium residues, carrier agents such as maltodextrin or silica, moisture less than 10%
Additives: None unless specified for preservation; may include stabilizers depending on product
CAS Number: 19398-08-0 for C. butyricum isolate
Inhalation: Move exposed person to fresh air. Seek medical advice if respiratory symptoms arise.
Skin Contact: Wash affected skin with soap and water. Remove contaminated clothing.
Eye Contact: Flush eyes immediately with water for at least ten minutes. If irritation persists, obtain medical attention.
Ingestion: Rinse mouth; drink water to aid dilution. Seek medical care if adverse symptoms develop.
Notes for Medical Staff: Treat symptomatically. Allergic reactions are possible in rare cases, especially in immunocompromised people.
Protection for First Responders: Standard PPE such as gloves recommended.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam; product itself not flammable, but carriers or packaging may burn.
Unsuitable Extinguishing Media: Strong water jets directly on product residue
Special Hazards: Thermal decomposition of packaging can produce irritant fumes (carbon oxides, nitrogen compounds)
Protective Equipment: Wear self-contained breathing apparatus and protective clothing in enclosed areas.
Specific Methods: Cool container with water spray. Prevent runoff into drains. Remove possible ignition sources.
Personal Precautions: Avoid inhalation, minimize skin and eye contact, use gloves and mask in case of large spill. Wash hands after handling.
Protective Equipment: Lab coat, nitrile or latex gloves, safety goggles or face shield.
Environmental Precautions: Prevent release into surface waters, soil, or drains in excess amounts.
Spill Handling: Scoop or vacuum spilled powder. Dampen area to minimize dust. Dispose of according to local regulations.
Decontamination: Use standard detergent solutions to clean up residues, followed by disinfectants if required.
Handling: Open only in well-ventilated conditions. Use with proper PPE. Do not eat, drink, or smoke during handling. Follow biosafety protocols suitable for non-pathogenic bacterial cultures.
Storage Conditions: Store in original, airtight container at 2-8°C, away from direct sunlight, humidity, and sources of ignition.
Incompatibilities: Strong acids, oxidizers, or disinfectants may destroy the viability of the culture.
Special Requirements: Rotate stock, use oldest product first to maintain efficacy. Keep container tightly closed when not in use.
Occupational Exposure Limits: Not assigned for this bacterium; minimize exposure using engineering controls.
Engineering Controls: Local exhaust ventilation or use in biosafety cabinet preferable during large-scale or laboratory handling.
Eye/Face Protection: Safety glasses or chemical goggles
Skin Protection: Nitrile or latex gloves, long-sleeved lab coat or coveralls
Respiratory Protection: Dust mask or N95 particulate respirator if risk of airborne dust or aerosols
Hygiene Measures: Wash hands thoroughly after handling or before breaks and meal periods.
Appearance: Off-white to tan powder or beige liquid suspension depending on the formulation
Odor: Slightly musty to neutral
Odor Threshold: Not established
pH: Typically neutral in suspension (pH 6.5 to 7.5)
Melting/Freezing Point: Not applicable
Boiling Point: Not applicable
Flash Point: Not flammable
Evaporation Rate: Not applicable
Flammability: Not flammable as bacteria, but powders may support combustion of packaging
Vapor Pressure: Not relevant
Relative Density: Varies with carrier material, usually 0.6 - 0.8 g/cm³ for powder
Solubility: Dispersible in water
Partition Coefficient: Not established
Decomposition Temperature: Above 60°C for live bacteria
Other Data: Product contains living organisms, viability diminishes with temperature, moisture, and time
Chemical Stability: Stable under recommended storage conditions. Deactivation likely at temperatures over 40°C or in extreme humidity.
Reactivity: Low reactivity; product is inert aside from microbial metabolic activity.
Conditions to Avoid: Heat, moisture, direct sunlight, exposure to disinfectants or strong chemicals
Incompatible Materials: Strong acids, alkalis, oxidizing agents
Hazardous Decomposition: Breakdown of packaging can produce CO2, NOx gases
Polymerization: Not applicable
Acute Toxicity: Recognized as safe for use in food and feed applications at intended doses; LD50 not established, no reports of systemic toxicity from exposure in healthy subjects.
Skin/Eye Irritation: Can cause minor irritation in sensitive individuals. Rinse thoroughly on contact.
Sensitization: Rare allergic reactions, mainly in immunocompromised populations or with chronic exposure.
Chronic Effects: No known long-term toxicity associated with correct use.
Carcinogenicity/Mutagenicity: No evidence for carcinogenic or mutagenic activity.
Reproductive Toxicity: Not expected based on available data.
Epidemiology: Used in probiotics and livestock without documented harm in healthy hosts.
Ecotoxicity: Low—strain is part of soil microbiome, utilized in silage production and bioremediation. Risks minimal at normal use concentrations.
Persistence/Degradability: Bacteria do not persist outside favorable environments; rapidly die-off in adverse conditions.
Bioaccumulation Potential: Not relevant; does not bioaccumulate.
Mobility in Soil: Moderate; may temporarily colonize soil or water but returns to background levels promptly.
Other Adverse Effects: No significant effect on non-target organisms under appropriate agricultural use.
Disposal May:** Biodegrade with standard treatment.
Product Disposal: Small quantities may be disposed as normal laboratory waste. Large amounts should go to special bio-waste treatment plants or incineration, respecting local laws.
Packaging Disposal: Decontaminate by autoclave or chemical disinfectant before disposal as general solid waste.
Contaminated Materials: Disposable gloves, wipes or clothing possibly exposed to high loads must be disposed in sealed, labeled biohazard bags.
Precautions: Prevent contamination of water sources and natural environments.
UN Number: Not classified as dangerous goods under UN, ADR, IMDG, IATA criteria.
Proper Shipping Name: Non-hazardous bacterial culture
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Special Transport Precautions: Protect from extreme temperatures and moisture during transit. Ship in sealed, leak-proof containers.
Environmental Hazards: No documented risks. Avoid releases outside intended applications.
Relevant Regulations: Registered as safe for human and animal consumption in many countries (e.g., FDA GRAS status, EFSA QPS List, China’s National Food Safety Standard).
Labeling Requirements: Must list strain designation, manufacturer/supplier, batch number, use-by date, storage instructions.
International Inventories: Included in major chemical inventories as non-hazardous biological substance.
Other Safety Standards: Adhere to national workplace biohazard handling requirements, food safety guidelines for probiotics and feed additives.
Worker Training: Mandate basic biosafety and hygiene training for handlers and users.
