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Product Name: Closantel Sodium
Chemical Name: Sodium 2-chloro-4-(1-oxo-2-(4-chlorophenyl)ethyl)phenoxyacetate
Synonyms: Closantel sodium salt, Flukiver
Molecular Formula: C22H13Cl2IN2NaO2
Molecular Weight: 566.19 g/mol
Manufacturer Information: Provided on label or packaging
Intended Use: Veterinary anthelmintic agent, used in parasite control
Hazard Classification: Harmful if swallowed, irritant to eyes and skin, may cause respiratory irritation
GHS Label Elements: Warning symbol, exclamation mark
Signal Word: WARNING
Health Hazards: Risk of serious damage to eyes, skin sensitization noted in sensitive individuals, respiratory discomfort on inhalation
Environmental Hazards: Hazardous to aquatic life with long lasting effects
Emergency Overview: White or pale yellow powder, avoid dust formation, handle using protection
Chemical Identity: Closantel sodium
CAS Number: 61438-64-0
Concentration: 100% (pure substance)
Impurities or Additives: None significantly affecting classification
Inhalation: Move exposed person to fresh air, monitor breathing, seek medical attention for difficulty in breathing
Skin Contact: Remove contaminated clothing immediately, rinse skin with soap and water for at least 15 minutes, seek medical guidance if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek care immediately
Ingestion: Rinse mouth thoroughly, do not induce vomiting unless advised by medical personnel, seek immediate medical attention if large quantities swallowed
Emergency Notes: Symptoms may include headache, dizziness, abdominal pain; medical professionals should treat symptomatically
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, foam
Specific Hazards: Emits toxic fumes under fire conditions (hydrogen chloride, sodium oxides, nitrogen oxides, carbon oxides)
Firefighter Protection: Self-contained breathing apparatus, full protective suit
Explosion Data: Not considered to have explosive properties
Fire Response: Avoid inhalation of smoke, keep containers cool with water spray if safe to do so
Personal Precautions: Avoid dust formation, use personal protective equipment, evacuate unnecessary staff
Environmental Precautions: Prevent material from entering drains or watercourses
Methods for Cleanup: Sweep up using non-sparking tools, collect into suitable containers for disposal, ventilate the area, clean spill area with plenty of water
Handling: Use only with adequate ventilation, avoid contact with skin and eyes, do not breathe dust, wash thoroughly after handling, keep away from incompatible materials like acids and oxidizers
Storage: Store in tightly closed container, in a cool, dry, well-ventilated area, keep away from food, feedstuffs, and drinking water, protect from light, store away from children and unauthorized personnel
Occupational Exposure Limits: No established limits for closantel sodium
Engineering Controls: Local exhaust ventilation recommended, safety shower and eyewash available
Personal Protection: Chemical-resistant gloves, safety goggles, laboratory coat, approved respirator if dust or aerosols are generated, avoid ingestion and inhalation by good hygiene practices
Environmental Controls: Keep away from surface water sources, handle with care to prevent environmental contamination
Appearance: White to pale yellow powder
Odor: Faint, characteristic
Odor Threshold: Not determined
pH: 9-11 (10% aqueous solution)
Melting Point/Freezing Point: Decomposes above 250°C (482°F)
Boiling Point: Not applicable (decomposes)
Flash Point: Non-flammable
Evaporation Rate: Not determined
Flammability: Not flammable
Upper/Lower Flammability Limits: Not applicable
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable
Specific Gravity/Density: 1.6 – 1.8 g/cm³
Solubility: Slightly soluble in water and organic solvents
Partition Coefficient (n-octanol/water): 6.4
Auto-ignition Temperature: Not determined
Decomposition Temperature: Above 250°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Possibility of Hazardous Reactions: No hazardous polymerization expected
Conditions to Avoid: Excessive heat, incompatible chemicals, moisture
Incompatible Materials: Strong acids, strong oxidizers
Hazardous Decomposition Products: Toxic gases such as hydrogen chloride, sodium oxides, carbon oxides
Acute Toxicity: Oral LD50 (rat) 118-240 mg/kg; may cause symptoms such as incoordination, depression, ataxia, CNS disturbances
Chronic Toxicity: Prolonged or repeated exposure may affect liver, eye, and nervous system
Skin Corrosion/Irritation: Mild to moderate irritant
Serious Eye Damage/Irritation: Causes severe eye damage
Respiratory or Skin Sensitization: May cause allergic reactions in sensitive individuals
Carcinogenicity: No data suggesting carcinogenic effects
Mutagenicity: Not classified as mutagenic based on available data
Reproductive Toxicity: Studies in animals indicate possible effects on embryo development at high exposures
STOT (Specific Target Organ Toxicity): Can affect the nervous system, liver, and eyes
Toxicity to Aquatic Life: Highly toxic; LC50 (fish, 96h) 0.47 mg/L; EC50 (daphnia, 48h) 0.20 mg/L
Persistence and Degradability: Not readily biodegradable, may persist in soil and water
Bioaccumulative Potential: High potential for bioaccumulation (log Kow 6.4)
Mobility in Soil: Tends to bind with soil particles, limited movement
Other Adverse Effects: Toxic to birds and invertebrates, avoid discharge to environment
Disposal Methods: Collect spilled material in suitable containers for approved chemical waste disposal
Hazardous Waste Classification: May be considered a hazardous waste based on local legislation
Contaminated Packaging: Clean containers before recycling or disposal, dispose of as hazardous waste if residue remains
Disposal Precautions: Do not dispose in household refuse, do not allow material to reach sewage system or water bodies, follow governmental regulations regarding chemical waste
UN Number: UN 3077
UN Proper Shipping Name: Environmentally hazardous substance, solid, n.o.s. (contains closantel sodium)
Transport Hazard Class: 9 (Miscellaneous dangerous substances)
Packing Group: III
Environmental Hazards: Marine pollutant
Transport Precautions: Prevent packaging damage, avoid spillage during transport, observe relevant local and international transport regulations
Safety, Health, and Environmental Regulations: Product classified under GHS for acute toxicity and environmental hazard; comply with national/international regulations such as OSHA, REACH, TSCA
Labeling Requirements: Appropriate hazard pictograms, warning statements as per GHS and local rules
Inventory Status: Listed or exempted under key regulatory inventories
Restrictions: Veterinary use only, sale and handling restricted by regional health agencies
Other Regulatory Information: Consult country-specific and state-specific regulations for handling, exposure limits, usage, and disposal rates
