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Material Safety Data Sheet: Citrus Bioflavonoids

Identification

Product Name: Citrus Bioflavonoids
Synonyms: Citrus Extract, Citrus Flavanone Complex
CAS Number: 520-26-3 (representative for hesperidin component)
Manufacturer: Supplier-specific information required
Recommended Use: Nutritional supplement, food additive, cosmetic ingredient
Contact Information: Manufacturer address and phone required for emergencies

Hazard Identification

Classification: Not classified as hazardous under GHS for typical concentrations; rare cases of dust irritants
Signal Word: None required
Hazard Statements: Dust may cause mild respiratory irritation and temporary discomfort if inhaled
Precautionary Statements: Avoid breathing dust; wash hands after handling; prevent eye contact to avoid irritation
Potential Health Effects: Inhalation may trigger coughing or sore throat; eye contact can cause redness or tearing; ingestion unlikely to cause toxic effects at anticipated exposure; no chronic toxicity known from standard use
Environmental Hazards: Not expected to result in significant hazard to aquatic or terrestrial systems

Composition / Information on Ingredients

Active Ingredient: Citrus Bioflavonoids (60-100%)
Common Components: Hesperidin, Naringin, Diosmin, Eriocitrin, Rutin
Impurities: Trace levels of residual citrus essential oils, water (<5%)
Additives: None typically added; check supplier’s full ingredient list for exceptions
Purity: Typically exceeds 90% active material; remaining content is natural plant matter

First Aid Measures

Inhalation: Move to fresh air; seek medical help if persistent respiratory symptoms develop
Skin Contact: Wash with mild soap and water; discontinue contact if rash or persistent irritation occurs
Eye Contact: Rinse carefully with water for several minutes; remove contact lenses if present and continue rinsing
Ingestion: Rinse mouth, drink water for comfort, contact poison control or healthcare provider for large exposures or sensitivities
Advice for Physicians: Symptomatic treatment only; no antidote necessary

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, foam, dry chemical, or CO2
Specific Hazards: Combustible dust can build up and may combust if exposed to strong ignition
Special Protective Equipment: Firefighters need full protective gear including self-contained breathing apparatus
Hazardous Combustion Products: Carbon dioxide, carbon monoxide, volatile organic compounds may form upon burning
Precautions: Avoid dust formation; use procedures to avoid breathing smoke or fumes

Accidental Release Measures

Personal Precautions: Use dust mask and safety goggles if high airborne dust; limit skin contact
Environmental Precautions: Prevent contamination of water streams in case of large spill
Methods for Clean Up: Shovel or vacuum spill into suitable, labelled containers; minimize airborne dust by gentle sweeping and wetting material
Cleaning Procedure: Clean area with mild detergent and water; ventilate if dust forms

Handling and Storage

Handling: Use local exhaust if working with large volumes or powders; avoid generating dust; keep away from ignition sources
Storage: Store in tightly sealed containers; keep in cool, dry locations; prevent exposure to sunlight and moisture
Incompatibilities: Avoid strong oxidizing agents, acids, and bases to maintain stability
Hygiene Practices: Wash hands before eating or drinking; launder contaminated clothing before reuse

Exposure Controls and Personal Protection

Engineering Controls: Ensure workplace has adequate ventilation, especially where dust could build up
Eye Protection: Wear chemical safety goggles if airborne dust risk present
Respiratory Protection: Dust mask or respirator (NIOSH approved) for heavy dust or confined areas
Hand Protection: Standard protective gloves for sensitive skin
Other Protective Equipment: Protective work clothing if prolonged exposure is likely

Physical and Chemical Properties

Appearance: Fine yellow to brown powder
Odor: Characteristic faint citrus aroma
Odor Threshold: Not established
pH: 4-7 (aqueous solution)
Melting Point/Freezing Point: Not applicable for multicomponent powder, individual flavonoids range from 250°C - 270°C
Boiling Point: Not relevant as material decomposes before boiling
Flash Point: Not available
Evaporation Rate: Not applicable
Flammability: Contains organic powder, so may present risk of dust explosion if suspended
Vapor Pressure/Density: Negligible under normal conditions
Solubility: Slightly soluble in water, soluble in alcohols
Partition Coefficient (n-octanol/water): No data
Decomposition Temperature: Above 250°C
Viscosity: Not applicable

Stability and Reactivity

Chemical Stability: Stable under ambient conditions, best kept dry and out of direct sunlight
Possibility of Hazardous Reactions: No dangerous reactions expected under normal use
Conditions to Avoid: Excess heat, strong oxidizers, open flame, moisture
Materials to Avoid: Strong acids and bases, oxidizing agents
Hazardous Decomposition Products: Burning or thermal decomposition forms carbon oxides and minor organic byproducts

Toxicological Information

Acute Toxicity: Oral LD50 for humans and rodents exceeds 2,000 mg/kg; practically non-toxic at normal exposure
Skin Corrosion/Irritation: Not an irritant based on available data; persons with citrus allergies may experience reactions
Serious Eye Damage/Irritation: Mild, transient irritation possible if dust contacts eyes
Respiratory or Skin Sensitization: No evidence of long-term sensitization, though citrus allergies are relevant
Carcinogenicity, Mutagenicity, Reproductive Toxicity: Not listed by IARC, NTP, OSHA as carcinogen; studies show no relevant risk in typical applications
Other Effects: Large oral doses may cause mild digestive upset

Ecological Information

Ecotoxicity: Not expected to harm aquatic or land environments at anticipated exposure levels
Persistence and Degradability: Biodegradable over time; breaks down through microbial action
Bioaccumulation Potential: No accumulation expected due to plant origin and natural biodegradation
Mobility in Soil: Moves with surface water if released, but breaks down under sunlight and microbial activity
Other Adverse Effects: None identified from environmental monitoring of flavonoids

Disposal Considerations

Waste Treatment Methods: Small amounts can go in regular landfill waste; larger volumes handled as non-hazardous organic material
Container Disposal: Empty and triple-rinse all containers before recycling or disposal
Special Precautions: Prevent large quantities from entering watercourses or open soil
Safe Handling: Dust control measures and good personal hygiene reduce waste hazards significantly

Transport Information

UN Number: Not regulated under ADR/RID, IMDG or IATA
UN Proper Shipping Name: Not classified as a dangerous good
Transport Hazard Class: None assigned
Packing Group: Not regulated
Marine Pollutant: Not considered harmful to the environment for shipping
Special Precautions: Secure containers to avoid dust dispersal and physical damage during transport

Regulatory Information

US TSCA Status: Exempt as a naturally occurring material
EU REACH Registration: Individual flavonoids may be registered as food ingredients
SARA Title III (Section 313): Not listed
OSHA Status: Not regulated as hazardous material
Canada DSL/NDSL: Components are listed or exempt
Label Requirements: Comply with local, state, and national laws for labeling food, supplement, or cosmetic materials