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Product Name: Citrus Aurantium Extract – Synephrine
Chemical Name: 4-[1-hydroxy-2-(methylamino)ethyl]phenol
CAS Number: 94-07-5
Common Names: Bitter Orange Extract, p-Synephrine
Recommended Use: Dietary supplement ingredient, research chemical
Supplier: [Supplier Information Needed]
Contact for Emergency: Emergency phone number based on global regulations
Classification: Acute oral toxicity (Category 4), Eye irritation (Category 2A), Skin irritation (Category 2)
Label Elements: Warning symbol (exclamation mark), Signal word: Warning
Hazard Statements: May cause moderate eye and skin irritation, Harmful if swallowed, May result in gastrointestinal disturbances, Potential for allergic reactions in sensitive individuals
Precautionary Statements: Avoid breathing dust, Use personal protective equipment, Wash thoroughly after handling, Do not eat, drink, or smoke when using this product
Main Ingredient: Citrus Aurantium Extract (Synephrine) 95% min by HPLC
Other Components: Cellulose, dextrin, trace flavonoids, and glycosides
Impurities: Less than 2%, typically residual plant matter and moisture
Hazardous Components: No components present at levels classified as hazardous beyond synephrine itself
Inhalation: Remove to fresh air, keep at rest, seek medical attention on persistent irritation.
Skin Contact: Wash area with soap and plenty of water, remove contaminated clothes, consult physician on persistent redness.
Eye Contact: Rinse cautiously with water for 10-15 minutes, remove contact lenses if present, consult doctor if irritation continues.
Ingestion: Rinse mouth with water, seek medical advice if symptoms such as nausea or abdominal discomfort appear.
Symptoms of Overexposure: Irritation to eyes, skin, mucous membranes, stomach pain, palpitations possible with large ingestion
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical, or foam.
Hazards from Combustion: Emits toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides under fire conditions.
Protective Equipment: Firefighters should use self-contained breathing apparatus and protective clothing to prevent contact.
Special Precautions: Avoid inhalation of combustion by-products, ventilate area after extinguishing
Personal Precautions: Ventilate area, use appropriate protective equipment such as gloves and safety goggles.
Environmental Precautions: Prevent further leakage or spillage if safe to do so, avoid discharge into the environment.
Cleanup Measures: Sweep up and place in a suitable container for disposal, wash spill site after material pickup, avoid generating dust
Handling: Handle in a well-ventilated place, wear personal protection, avoid formation of dust, do not get in eyes or on skin.
Storage: Keep container tightly closed in a dry, cool, well-ventilated area, protect from moisture and direct sunlight, keep away from incompatible substances such as strong oxidizers.
Special Storage Conditions: Store away from food, beverages, and animal feed
Engineering Controls: Use local exhaust ventilation or process enclosure to control airborne levels below recommended exposure limits.
Personal Protection: Wear protective gloves (nitrile, latex), chemical safety goggles, laboratory coat, dust mask if airborne particles possible.
Hygiene Measures: Wash hands, forearms and face thoroughly after handling, do not eat, drink or smoke during use.
Exposure Limits: No specific local occupational exposure limits established for this compound, general dust limit guidelines recommended
Appearance: Pale yellow to brown fine powder
Odor: Faint citrus, slightly bitter
pH (1% solution): 4.0 – 6.0
Melting Point: Not exactly defined, decomposes above 100°C
Boiling Point: Decomposition occurs before boiling
Solubility: Moderately soluble in water, soluble in ethanol
Flash Point: Not applicable (solid powder)
Auto-ignition Temperature: Not established
Vapor Pressure: Negligible at ambient temperatures
Density: 0.5 – 0.7 g/cm³
Partition Coefficient (n-octanol/water): Not available
Chemical Stability: Stable under normal conditions of storage and handling
Reactivity: Incompatible with strong acids, strong bases, and oxidizing agents
Decomposition: Thermal decomposition can produce carbon oxides and nitrogen oxides
Conditions to Avoid: Exposure to moisture, excessive heat, open flames, direct sunlight
Acute Toxicity: Oral LD50 (rat) estimated greater than 350 mg/kg body weight for synephrine
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Potential Effects: May cause irritation to eyes, skin, respiratory tract; high oral doses linked with increased blood pressure and palpitations
Chronic Exposure: May aggravate existing cardiovascular conditions, not listed as a known carcinogen, mutagen, or reproductive toxin by ACGIH, IARC, NTP, or OSHA
Sensitization: Possible allergic responses, particularly in individuals sensitive to citrus
Ecotoxicity: No data for synephrine; expected to present low risk at typical environmental concentrations
Mobility in Soil: Moderate mobility due to water solubility
Persistence and Degradability: Biodegradable under typical environmental conditions
Bioaccumulation: Not expected to bioaccumulate significantly
Aquatic Toxicity: Not classified due to lack of relevant data; caution recommended to prevent major spills in waterways
Waste Treatment Methods: Dispose of contents/container in accordance with national and local regulations
Contaminated Packaging: Rinse well and dispose of as non-hazardous chemical waste
Incineration: Suitable for material destruction at approved facilities
Prevent Release: Do not discharge into drains, waterways, or soil
UN Number: Not classified as dangerous goods for transport under ADR, IMDG, IATA, RID regulations
Proper Shipping Name: Not regulated
Hazard Class: Not applicable
Packing Group: Not applicable
Marine Pollutant: No
Special Precautions: Protect from moisture, pack in tightly sealed containers
TSCA Status: Not listed specifically, but plant-derived compounds may be subject to review
EU Regulation: Not classified as hazardous under EU CLP Regulation (EC) No 1272/2008
Other Regulations: Subject to dietary supplement and food additive regulations as per region
Workplace Regulations: General chemical handling requirements apply, not classified as controlled substance
Labeling Requirements: Safety and risk phrases, supplier contact details where necessary
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
