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Product Name: Chromium Polynicotinate
Synonyms: Chromium Nicotinate Glycinate; Chromium(III) trinicotinate
Chemical Class: Chromium Compound, Organic Salt
Molecular Formula: C18H12CrN3O6
Molecular Weight: Approximately 418.3 g/mol
Manufacturer Information: Refer to current supplier registry or local distributor for details.
Recommended Uses: Used as a nutritional supplement, ingredient in health and wellness products.
Restrictions on Use: Intended for research or supplement manufacturing purposes only; not for direct ingestion in raw form.
Classification: May cause respiratory irritation; Eye and skin irritant; Suspected of causing genetic defects through chronic exposure.
Signal Word: Warning
GHS Hazard Pictograms: Exclamation mark; Health hazard
Hazard Statements: May be harmful if swallowed or inhaled; Causes eye irritation; May cause long term adverse effects in the aquatic environment.
Precautionary Statements: Avoid dust generation; Wear protective gloves and safety goggles; Wash hands thoroughly after handling; Store in well-ventilated, dry area.
Chemical Name: Chromium Polynicotinate
CAS Number: 64452-96-6
Chromium (III): Trace amount, roughly 2-3% by weight
Nicotinic Acid: About 95–97% by rest mass
Impurities: May contain small amounts of water, trace metals from manufacturing, not exceeding standardized thresholds.
Inhalation: Move exposed individual to fresh air; seek medical attention if breathing becomes difficult; provide oxygen if trained and required.
Skin Contact: Remove contaminated clothing immediately; wash affected area under running water for at least 15 minutes; call physician if irritation persists.
Eye Contact: Rinse eyes cautiously with lukewarm water for at least 15 minutes while keeping eyelids open; seek medical attention promptly.
Ingestion: Rinse mouth; do not force vomiting; provide water if victim is alert; contact medical personnel immediately.
Note to Physicians: Provide supportive treatment; monitor respiratory and cardiovascular functions.
Suitable Extinguishing Media: Use foam, dry chemical, or carbon dioxide; avoid water jets.
Unsuitable Media: Direct water spray may spread material.
Hazardous Combustion Products: Thermal decomposition can release oxides of chromium and nitrogen, possibly toxic.
Protective Equipment: Wear self-contained breathing apparatus and full firefighting gear.
Firefighting Advice: Move containers from fire area if safe; prevent runoff from entering drains or waterways.
Personal Precautions: Wear mask, gloves, goggles; avoid dust formation.
Environmental Precautions: Prevent further leakage or spillage; avoid entry into sewers, surface or groundwater.
Cleanup Methods: Scoop up spilled product into suitable container; wipe area with damp cloth to reduce dust; ventilate area.
Disposal of Cleanup Materials: Place waste in tightly sealed container for proper disposal per regulatory recommendations.
Precautions for Safe Handling: Handle in well-ventilated spaces; avoid generating dust; prevent contact with skin and eyes; keep containers tightly closed when not in use.
Safe Storage Conditions: Store away from direct sunlight, heat sources, and incompatible substances; preferred temperature below 25°C; keep substance in sealed original packaging.
Storage Incompatibilities: Keep away from strong oxidizers, bases, and acids.
Occupational Exposure Limits: No established OSHA, NIOSH, or ACGIH TLV for chromium polynicotinate as a whole; for Chromium (III) compounds: ACGIH TLV 0.5 mg/m³ (as Cr).
Engineering Controls: Ensure local exhaust ventilation or use enclosed processes where feasible.
Respiratory Protection: Wear NIOSH-approved dust respirator in situations of potential dust formation.
Eye Protection: Chemical splash goggles recommended.
Skin Protection: Impermeable gloves and protective clothing advised.
Hygiene Measures: Refrain from eating or drinking in work area; wash hands and face before breaks and after work.
Physical State: Fine, odorless powder
Color: Reddish to violet
Odor Threshold: Not established
pH (1% solution): 5-7
Melting Point/Range: Decomposes above 200°C
Boiling Point: Not applicable
Flash Point: Not flammable under standard conditions
Vapor Density: Not applicable
Solubility: Slightly soluble in water; insoluble in organic solvents
Partition Coefficient (log Kow): Not determined
Auto-ignition Temperature: Not determined
Decomposition Temperature: 200°C (approximate)
Evaporation Rate: Not relevant for solid
Chemical Stability: Stable under standard handling and storage conditions.
Conditions to Avoid: High temperature, exposure to strong acids and bases, contact with oxidizing agents.
Incompatible Materials: Concentrated acids, alkalis, oxidizers.
Decomposition Products: Chromium oxides, nitrogen oxides, possibly irritating fumes.
Polymerization Risk: No hazardous polymerization under normal circumstances.
Acute Toxicity: Oral LD50 (rat): Data limited; not considered highly toxic in small dietary amounts.
Skin/Eyes: Possible irritant to mucous membranes; can cause redness, itching, swelling.
Inhalation: Dust may cause irritation of respiratory tract.
Chronic Effects: Prolonged high-level exposure might contribute to kidney or liver effects, based on chromium data.
Mutagenicity: Limited evidence in animal studies—monitoring advised.
Carcinogenicity: No direct evidence for chromium polynicotinate; hexavalent chromium compounds are known carcinogens, but not relevant here.
Reproductive Toxicity: No direct evidence found in available research.
Sensitization: Possible allergic reaction, especially in sensitive individuals.
Ecotoxicity: May cause harm to aquatic organisms if significant quantities reach waterways.
Persistence and Degradability: Not readily biodegradable; regulated disposal recommended.
Bioaccumulation: Data limited; unlikely to bioaccumulate due to low water solubility.
Mobility in Soil: Tends to bind to soil particles, minimizing migration.
Other Adverse Effects: Avoid uncontrolled release; follow best environmental practices.
Waste Disposal Methods: Dispose in accordance with federal, state, and local regulations for chromium compounds.
Contaminated Packaging: Triple rinse containers and dispose of as hazardous waste if required.
Environmental Precautions: Do not discard into drains or natural water bodies.
Recommended Disposal Route: High-temperature incineration in permitted facility or chemical landfill following pretreatment.
UN Number: Not assigned for this compound.
Proper Shipping Name: Not regulated for ground, air, or sea transport.
Transport Hazard Class: Not classified as dangerous goods under current transport regulations.
Packing Group: Not applicable.
Special Precautions: Protect from moisture and physical damage during shipping.
Environmental Hazards: Not designated as a marine pollutant.
US TSCA: Registered
DSL/NDSL (Canada): Listed
REACH (EU): Registration under process or required for bulk manufacturing
SARA Title III: Not listed as an extremely hazardous substance
RCRA Status: May be considered hazardous waste if chromium concentration exceeds limits
WHMIS Classification: Not classified as hazardous in small pure supplement use, but consult local authority.
Other International Regulations: Check compliance status under regional environmental, workplace safety, and food additive codes.
Labeling Requirements: All packaging should clearly display chemical name, hazard pictograms, manufacturer contact, batch, and safety instructions.
