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Choline Chloride Material Safety Data Sheet (MSDS)

Identification

Product Name: Choline Chloride
Chemical Formula: C5H14ClNO
Synonyms: Choline hydrochloride, Vitamin B4
CAS Number: 67-48-1
Recommended Use: Used in animal feed, as a nutrient supplement, chemical reagent
Supplier Details: Manufacturer or supplier address, contact number for questions regarding product safety, emergency phone numbers listed

Hazard Identification

GHS Classification: Eye Irritant Category 2A, Skin Irritant Category 3
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, may cause mild skin irritation, dust can lead to respiratory discomfort
Pictograms: Exclamation mark
Precautionary Statements: Avoid dust formation, wash exposed skin thoroughly, wear protective gloves and eye protection, avoid breathing in dust
Potential Health Effects: Inhalation can irritate mucous membranes, eyes may water and turn red, ingestion may cause abdominal cramps and diarrhea

Composition / Information on Ingredients

Choline Chloride: 98–99%
Other Components: Water 0.5–1.5%, possible trace impurities including dimethyl ethanolamine
Impurities: Does not contain hazardous stabilizers or solvents, meets typical purity standards for feed additives

First Aid Measures

Inhalation: Remove person to fresh air, provide rest and warmth, seek medical attention for any breathing difficulties
Eye Contact: Rinse with plenty of water for 10–15 minutes, lift eyelids to ensure thorough rinsing, seek further medical help if irritation continues
Skin Contact: Remove contaminated clothing, wash skin with soap and plenty of water, consult doctor if irritation develops
Ingestion: Give water to drink if conscious, do not induce vomiting, obtain medical advice immediately

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, foam, dry powder, carbon dioxide
Unsuitable Media: Avoid direct water jet on product dust which may spread the fire
Hazards from Combustion: May release toxic fumes including hydrogen chloride, nitrogen oxides, and carbon monoxide in a fire
Protective Equipment: Firefighters need self-contained breathing apparatus and full protective clothing
Firefighting Instructions: Cool containers exposed to heat with water, prevent runoff into drains and sewers where feasible

Accidental Release Measures

Personal Precautions: Avoid raising dust, wear protective gloves, safety goggles, NIOSH-approved respirator in case of significant dust
Environmental Precautions: Prevent entry into drains, sewers, watercourses, and soil
Cleanup Methods: Sweep up and shovel into suitable container for disposal, clean spill area with water
Disposal: Dispose of collected material at a licensed facility in compliance with local, regional, and national regulations

Handling and Storage

Handling: Use in well-ventilated area, avoid contact with skin, eyes, and clothing, minimize dust generation, avoid eating, drinking, or smoking when handling this product, wash hands thoroughly after use
Storage: Keep container tightly closed, store in a cool, dry and well-ventilated place, protect from moisture, keep away from incompatible substances like strong oxidizers and acids, label storage area with hazard warnings

Exposure Controls and Personal Protection

Occupational Exposure Limits: No published exposure limits, use workplace dust exposure limits as guidance
Engineering Controls: Provide local exhaust ventilation if dust is generated, maintain good general ventilation in working area
Personal Protective Equipment: Respiratory mask in case of insufficient ventilation, safety goggles, chemical resistant gloves, protective clothing to prevent skin exposure
Hygiene Measures: Change and wash clothing after handling, do not eat or drink in the work area

Physical and Chemical Properties

Physical State: Fine crystalline powder or colorless to pale yellow flakes
Odor: Mild, fishy smell
Molecular Weight: 139.62 g/mol
pH (1% Solution): 5.0–7.0
Melting Point: 302°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Highly soluble in water, slightly soluble in ethanol
Density: Approximately 1.1 g/cm³
Vapor Pressure: Not significant at ambient temperature

Stability and Reactivity

Stability: Stable under normal conditions, sensitive to moisture
Reactivity: No hazardous reactions under storage and handling as recommended
Incompatible Materials: Strong oxidizing agents, acids, water exposure may cause caking
Decomposition: On heating, generates hazardous gases including hydrogen chloride, carbon monoxide, nitrogen oxides
Polymerization: Not known to occur

Toxicological Information

Acute Toxicity: Oral LD50 (rat): > 3000 mg/kg (relatively low toxicity)
Skin Contact: May cause mild irritation, no known cases of sensitization
Eye Contact: Causes moderate to severe eye irritation similar to exposure to many dusts
Inhalation: Irritation to respiratory tract, coughing, sore throat if inhaled in quantity
Chronic Effects: No evidence of chronic toxicity at levels typically found in occupational exposure or supplementation
Carcinogenicity: Classified as not carcinogenic, not listed by IARC, NTP, OSHA
Mutagenicity: Not found to be mutagenic in established tests

Ecological Information

Ecotoxicity: Not expected to be harmful to aquatic organisms at typical release quantities, high concentration or spills could cause nutrient enrichment in water systems
Persistence and Degradability: Readily biodegradable in the environment, low bioaccumulation potential
Mobility in Soil: Highly mobile, dissolves and disperses easily in moist environments
Other Adverse Effects: May contribute to algal blooms in water due to nutrients if significant release occurs

Disposal Considerations

Product Disposal: Dispose of through a licensed chemical waste disposal contractor, incinerate or landfill only where local regulations permit
Packaging Disposal: Triple rinse empty containers, render unusable, recycle or dispose according to regional guidelines
Environmental Precautions: Prevent uncontrolled release to the environment, avoid disposal into surface water, storm drains, or soil

Transport Information

UN Number: Not classified as hazardous for transport under UN, IMDG, IATA, DOT
Proper Shipping Name: Choline Chloride
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Special Precautions: Protect from moisture and physical damage during transport, keep containers clearly labeled
Environmental Hazards: Not regulated as marine pollutant

Regulatory Information

US Regulations: Not listed as a hazardous substance under CERCLA, EPCRA, SARA Title III Sections 302, 311/312, or 313
OSHA: Not specifically regulated
TSCA: Listed on TSCA Inventory
EU Regulations: Complies with REACH for substances manufactured or imported in the EU, not classified as dangerous according to CLP Regulation
Other National/International: Included in relevant chemical inventories in Canada, Australia, Japan, China, Korea, Philippines, supports compliance with local PTA and Safety Regulations
Labeling Requirements: Ensure all containers carried hazard warnings, reference safety instructions for users