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Product Name: Carnosic Acid
Chemical Formula: C20H28O4
CAS Number: 3650-09-7
Synonyms: Rosemary extract acid, Rosemarinic diterpene
Recommended Use: Natural antioxidant in cosmetics, food preservatives, dietary supplements
Supplier: Manufacturer’s details to be verified per shipment
Emergency Contact: In case of spill, exposure, or accident, contact regional poison control or emergency response center
Classification: Irritant to eyes, skin, and respiratory tract; Hazardous to aquatic environment
GHS Label Elements: Exclamation mark, aquatic hazard, health hazard signs
Signal Word: Warning
Hazard Statements: May cause allergic skin reaction. Causes serious eye irritation. Toxic to aquatic life with long lasting effects. Inhalation may produce respiratory tract irritation in dust or powdered forms.
Precautionary Statements: Wear gloves, protective clothing, avoid breathing dust, wash exposed skin thoroughly after handling, avoid release into waterways or the environment
Main Ingredient: Carnosic Acid
Concentration: 70%~98% (based on supplier specification)
Other Components: Plant extracts, trace solvents from processing, minor phenolic diterpenes such as carnosol and rosmarinic acid
Impurities: Composition varies by source, possible trace ethanol, water
Inhalation: Move affected person to fresh air, provide oxygen if breathing is difficult, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, flush skin with soap and plenty of water for at least 15 minutes, seek medical advice if rash or irritation persists
Eye Contact: Rinse cautiously with water for several minutes, remove contacts if possible, continue rinsing, seek medical attention for persistent irritation
Ingestion: Rinse mouth, drink plenty of water, avoid inducing vomiting unless instructed by medical personnel, obtain medical help if large amount swallowed or symptoms occur
Important Symptoms and Effects: Eye and skin irritation, coughing, nausea, may provoke allergic responses in sensitive individuals
Suitable Extinguishing Media: Dry chemical, water spray, foam, carbon dioxide
Unsuitable Media: Direct jet of water may spread powder and cause contamination
Specific Hazards: Produces smoke, carbon oxides, possible phenolic fumes when heated
Protective Equipment: Wear full protective gear, self-contained breathing apparatus; avoid inhaling fumes
Advice for Firefighters: Approach fire from upwind, contain spillage, avoid runoff into drains
Personal Precautions: Use personal protective equipment such as gloves, goggles, dust mask
Environmental Precautions: Prevent leakage into waterways, soil, sewage systems
Clean-Up Methods: Sweep up powder carefully, avoid generating dust, transfer to sealed container for disposal, ventilate affected area
Precautions for Safe Handling: Use only in well-ventilated areas, avoid contact with eyes and skin, do not eat, drink, or smoke during use
Hygiene Measures: Wash hands after handling, remove protective gear before eating
Storage Conditions: Store in cool, dry location, away from sunlight, heat sources, acids, or oxidizing agents
Packaging: Keep tightly closed in original packaging, protect from humidity and contamination
Storage Life: Typically stable for at least 24 months unopened at controlled temperature; follow supplier guidance for best durability
Exposure Limits: No established occupational exposure limits; take precautions to minimize dust
Engineering Controls: Ensure adequate local exhaust or general ventilation, use dust extraction systems for large-scale handling
Personal Protection: Wear chemical-resistant gloves, safety glasses with side shields, dust mask or NIOSH-approved respirator when handling powders
Hygiene Practices: Wash hands and face thoroughly after use, avoid touching eyes and mouth
Form: Fine powder, sometimes crystalline or amorphous
Color: Light brown to off-white
Odor: Faint herbal, characteristic of rosemary
Melting Point: 198–202°C (decomposition may occur)
Boiling Point: Decomposes before boiling
Solubility: Insoluble in water, soluble in ethanol, acetone, oils
pH: Not applicable as solid, slightly acidic when dissolved in ethanol
Vapor Pressure: Negligible at room temperature
Flash Point: >180°C
Partition Coefficient (log Kow): Approximately 6.03
Auto-ignition Temperature: Not determined
Chemical Stability: Stable under normal storage conditions and recommended handling
Conditions to Avoid: Excessive heat, sunlight, open flames, exposure to strong acids or oxidizers
Materials to Avoid: Strong acids, strong oxidizers, bases can break down or degrade carnosic acid
Hazardous Decomposition Products: Oxides of carbon, phenolic compounds, potential trace irritant fumes
Reactivity: Not highly reactive, but may react slowly with incompatible materials over time
Acute Toxicity: Data from animal studies indicate low acute oral and dermal toxicity
Routes of Exposure: Inhalation, ingestion, skin, eye contact
Symptoms: Irritation to eyes, skin, mucous membranes, allergic reactions may develop in some individuals
Chronic Effects: Long-term exposure in large quantities may affect liver or kidneys in animals; no clear evidence for human carcinogenicity
LD50 (oral, rat): >5000 mg/kg (low acute toxicity)
Mutagenicity: Not observed in Ames test and in vivo studies
Reproductive Toxicity: No indication of reproductive harm at levels encountered in food use
Additional Data: Safe in typical food additive concentrations based on regulatory reviews
Ecotoxicity: Harmful to aquatic organisms; possible long-term adverse effects in aquatic environments
Bioaccumulation Potential: High log Kow suggests possible bioaccumulation in aquatic species
Persistence: Moderately persistent, slowly biodegradable
Mobility: Low mobility in soil, binds to organic matter
Environmental Fate: Use away from open water bodies, observe local regulations for plant extracts
Aquatic Toxicity (LC50, fish): Data not fully established, extrapolated to be in low ppm range for sensitive species
Waste Treatment: Dispose according to regional, national, and local laws
Unused Product: Place in container for hazardous or special waste collection; do not discharge into drains, soil, or surface water
Contaminated Packaging: Rinse, treat as hazardous waste if contaminated, recycle if allowed
Additional Methods: Incinerate in authorized facilities, avoid landfill disposal to protect waterways
UN Number: Not classified as hazardous for transport
Transport Hazard Class: Non-dangerous according to most countries’ regulations
Packing Group: Not regulated
Special Precautions: Prevent dust formation, keep dry during storage and shipping
Environmental Hazard: Transport in sealed containers to avoid leakage, label as hazardous to aquatic environment if applicable
Labeling: Conforms to GHS, CLP, OSHA, WHMIS when applicable
Inventory Status: Listed or exempted on major chemical inventories (TSCA, EINECS, DSL, etc.)
Restrictions: Use in food and cosmetic applications must meet WHO, FDA, EFSA requirements; maximum levels apply in dietary supplements
Hazard Symbols: Irritant, environmental hazard
SARA Title III, California Proposition 65 Status: Not listed as carcinogen or reproductive toxicant
Worker Protection: Employees handling in bulk covered by safety protocols and regular training
