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Material Safety Data Sheet (MSDS) for Canthaxanthin

Identification

Product Name: Canthaxanthin
Chemical Formula: C40H52O2
Synonyms: Food Orange 8, E161g, β,β-Carotene-4,4'-dione
Product Use: Colorant in food, pharmaceuticals, feed additives, cosmetics
Manufacturer: Contact supplier directly for up-to-date information
Emergency Telephone: Refer to national poison center or producer’s emergency number
CAS Number: 514-78-3
EC Number: 208-187-2
Molecular Weight: 564.85 g/mol

Hazard Identification

Classification: Not classified as dangerous under GHS; can irritate eyes and skin
Acute Effects: Dust may irritate respiratory tract; accidental ingestion could affect gastrointestinal system
Chronic Effects: High chronic intake tied to retinal deposits and skin discoloration in rare cases
Signal Word: None required under GHS
Pictograms: None mandated
Hazard Statements: Avoid inhaling dust; avoid contact with skin, eyes
Precautionary Statements: Store in tightly sealed containers; wash thoroughly after handling

Composition / Information on Ingredients

Chemical Name: Canthaxanthin
Concentration: Usually >96% in pure form; could be lower in blends
Impurities: May include trace solvents or stabilizers depending on source
Hazardous Components: No major hazardous impurities known in commercial grades

First Aid Measures

Eye Contact: Rinse with water for 10-15 minutes, hold eyelids open
Skin Contact: Wash with soap and water; remove contaminated clothing
Inhalation: Move individual into fresh air; seek medical attention if symptoms persist
Ingestion: Rinse mouth; drink water; seek medical support if sick or large quantities swallowed
Notes for Doctor: Treat symptomatically; monitor for allergic reaction in sensitive individuals

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, CO2, foam, or water spray
Specific Hazards: Dust may form a combustible mixture in air; toxic fumes possible
Protective Equipment: Use self-contained breathing apparatus and protective firefighting gear
Special Procedures: Cool containers with water spray; prevent run-off from entering drains

Accidental Release Measures

Personal Precautions: Avoid dust generation; ventilate area; wear respirator if exposure risk
Environmental Precautions: Prevent entry into sewers and water sources
Clean-Up Methods: Sweep up carefully; avoid creating airborne dust; transfer waste to a labeled container for disposal; wash spill site after collection

Handling and Storage

Safe Handling Practices: Use local exhaust where dust is generated; avoid contact with skin or eyes; do not eat, drink, or smoke while handling
Storage Conditions: Store in cool, dry, well-ventilated area
Container Requirements: Keep tightly closed; use light-resistant, food-grade containers
Incompatible Materials: Strong oxidizers, acids, light, heat, humidity

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established occupational limits in most countries
Engineering Controls: Work under local exhaust or fume hood; regular workplace monitoring
Personal Protective Equipment: Gloves: Nitrile or latex for prolonged use
Eye Protection: Safety goggles
Respiratory Protection: NIOSH-approved dust mask if dust threshold exceeded
Clothing: Laboratory coat or overalls

Physical and Chemical Properties

Appearance: Red-orange crystalline powder
Odor: Odorless
Melting Point: 210-215°C
Solubility: Insoluble in water; soluble in fat, oil, chloroform
pH Value: Not applicable (insoluble in water)
Vapor Pressure: Not measurable at room temperature
Density: About 1.5-1.6 g/cm³
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Partition Coefficient: High (log Kow approx. 8.4, lipid-soluble)

Stability and Reactivity

Chemical Stability: Stable under recommended conditions of storage
Conditions to Avoid: Exposure to light, elevated temperature, moisture
Incompatible Materials: Strong oxidizing agents
Hazardous Decomposition: Oxides of carbon, other toxic fumes possible with fire or thermal decomposition
Polymerization: Not expected under normal conditions

Toxicological Information

Routes of Entry: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: LD50 (oral, rat) >5000 mg/kg (low acute toxicity)
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, OSHA
Other Effects: Chronic high-dose exposure has caused retinal crystals and skin discoloration in rare, high-exposure cases
Signs and Symptoms: Mild irritation eyes/respiratory tract
Allergenic Effects: Rare; not a known skin sensitizer

Ecological Information

Ecotoxicity: Low environmental toxicity; naturally breaks down in sunlight
Bioaccumulation: Potential to bioaccumulate in aquatic systems due to fat solubility
Persistence / Degradability: Biodegradable under both aerobic and anaerobic conditions
Mobility: Strongly adsorbs to soils and sediment due to high log Kow
Water Hazard Class: Not classified as hazardous to water in most jurisdictions

Disposal Considerations

Waste Treatment: Dispose as non-hazardous waste following local, regional, national rules
Package Disposal: Triple rinse and offer for recycling or dispose in approved landfill
Special Instructions: Do not discharge concentrated product to waterways

Transport Information

UN Number: Not classified as dangerous for transport
Transport Hazard Class: Non-hazardous
Proper Shipping Name: Canthaxanthin
Packing Group: Not applicable
Environmental Hazards: None significant under normal transport conditions
Special Precautions: Protect from direct sunlight, moisture, and physical damage during shipment

Regulatory Information

TSCA: Listed in US Toxic Substances Control Act inventory
EINECS: Listed in European Inventory under number 208-187-2
REACH: Exempt or registered for intended uses
OSHA Status: Not regulated as a hazardous material
FDA: Approved as a color additive in food and feed at controlled limits
Other Regulations: Follow local country-specific rules for use in food, feed, or cosmetics