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Product Name: Caffeine
Chemical Formula: C8H10N4O2
CAS Number: 58-08-2
EC Number: 200-362-1
Recommended Use: Stimulant, pharmaceutical, research chemical
Supplier Details: Information should come directly from the supplier used by each facility for traceability, including address and contact details.
Emergency Phone Number: Refer to site-specific emergency contacts used by facility.
Classification: Acute Toxicity (Oral) Category 4, Eye Irritation Category 2A
Signal Word: Warning
Hazard Statements: Harmful if swallowed; causes serious eye irritation
Precautionary Statements: Avoid breathing dust; wash hands thoroughly after handling; do not eat, drink or smoke when using the product; wear eye protection
Hazard Symbols: Exclamation mark
Other Hazards: Dust can irritate respiratory system; individuals with heart conditions face greater risk from excessive exposure
Chemical Name: Caffeine
Purity: 98–100%
Common Impurities: Trace moisture, minor organic residues below 1%
Ingredient: Caffeine Anhydrous
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing; seek medical advice if irritation persists
Skin Contact: Remove contaminated clothing; wash with soap and water; seek medical attention if irritation develops
Ingestion: Rinse mouth; call poison control if large amount is swallowed; drink water if conscious, do not induce vomiting unless instructed
Inhalation: Move to fresh air; seek medical attention if symptoms occur, such as coughing or shortness of breath; support breathing as needed
Symptoms of Exposure: Nausea, headache, irritability, tachycardia, dizziness, tremors, seizures at high doses
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam for small fires
Unsuitable Media: Avoid high pressure water jets
Specific Hazards: May produce irritating fumes such as oxides of carbon and nitrogen under fire conditions
Protective Equipment: Firefighters require self-contained breathing apparatus, full protective turnout gear
Special Procedures: Keep exposed containers cool with water; prevent run-off from entering drains or watercourses; evacuate nonessential personnel
Personal Precautions: Avoid inhalation of dust, wear suitable protective clothing, gloves, and eye protection
Environmental Precautions: Prevent from entering water systems and drains
Clean-up Methods: Sweep up and collect into suitable container for disposal without raising dust; ventilate area after clean-up
Reporting: Notify authorities if significant spill affects drainage or waterways
Handling: Use in a well-ventilated, low-dust area; avoid contact with skin, eyes, and clothing; do not eat or smoke while using; wash hands after use
Storage: Store in tightly closed container in a cool, dry, well-ventilated area; keep away from incompatible materials such as strong oxidizers; keep out of reach of children; label clearly with hazard information
Special Requirements: Protect from light, moisture, and physical damage
Occupational Exposure Limits: No specific OSHA or ACGIH exposure limits established; general dust limits apply (OSHA PEL–15 mg/m³ for total dust)
Engineering Controls: Ventilation systems to reduce airborne dust; handle in fume hood or under local exhaust when possible
Personal Protection: Use safety glasses with side-shields or chemical goggles, nitrile gloves, lab coat; dust mask or NIOSH-approved respirator for high concentrations
Hygiene Measures: Remove contaminated clothing and wash before reuse; wash hands after handling
Monitoring: Use workplace monitoring to measure caffeine dust levels in high-use settings
Appearance: White, odorless crystalline powder
Molecular Weight: 194.19 g/mol
Melting Point: 234°C–238°C
Boiling Point: Sublimes at 178°C
Solubility in Water: 22 g/L at 25°C
Vapor Pressure: Negligible at room temperature
pH: Slightly acidic in solution
Flash Point: Not flammable under normal use
Explosion Properties: Dust-air mixtures may form explosive combinations in rare cases
Chemical Stability: Stable under storage conditions recommended (dry, cool, shielded from light)
Reactivity: Not considered reactive under normal conditions
Incompatible Materials: Strong oxidizers (e.g., peroxides, permanganates), acids, reducing agents
Decomposition Products: Toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides at high temperatures
Conditions to Avoid: Moisture, excessive heat, ignition sources
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Acute Toxicity (Oral LD50): 192 mg/kg (rat), can be lower in some animal models
Symptoms of Overexposure: Restlessness, insomnia, tremors, palpitations, gastrointestinal upset; very high doses can cause seizures or death
Chronic Toxicity: Extended exposure may worsen anxiety, cause heart palpitations or digestive problems
Carcinogenicity: Not listed by NTP, IARC, OSHA as carcinogenic
Other Data: Increased sensitivity for pregnant individuals, those with heart conditions
Eco-Toxicity: Low acute toxicity to aquatic life based on available testing; slow biodegradation in the environment
Persistence and Degradability: Moderately persistent in water; breaks down slowly in soil
Bioaccumulation Potential: Low; not likely to build up in aquatic organisms
Mobility in Soil: Moderate; caffeine can travel short distances in moist soil
Other Environmental Hazards: In large quantities, runoff may present hazard to small water bodies; improper disposal could disrupt microbial ecosystems
Waste Disposal Methods: Dispose of through licensed chemical disposal contractor; follow local, regional, and national regulations
Packing Contaminated Material: Place in sealed, labelled containers for incineration or landfill; avoid dust formation
Special Precautions: Never flush large amounts into sewer; avoid release to environment; consult authorities for significant spills
Disposal of Containers: Decontaminate before recycling or dispose of as hazardous waste if contaminated
UN Number: Not classified as hazardous for ground, sea, or air transport
Transport Hazard Class: Not regulated according to most international guidelines
Packing Group: None assigned
Special Transport Precautions: Ship in sturdy containers; keep away from moisture; label with contents and hazard warnings if applicable
Environmental Hazards During Transport: Spill risks; dust clouds must be avoided
U.S. Regulations: Not listed as a hazardous substance under CERCLA, SARA, or TSCA; food additive status regulated by FDA
EU Regulations: Classified as non-hazardous substance according to Regulation (EC) No 1272/2008; subject to REACH registration if imported above certain tonnage
Labeling Requirements: Container must display hazard warnings and usage guidance
Workplace Controls: OSHA-compliant labelling, safety procedures, and staff training expected in occupational settings
Other Country-Specific Regulations: Local environmental controls and workplace limits can apply based on use scenario, consult national inventory databases for legal requirements
