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Product Name: Tributyrin
Chemical Name: Glyceryl tributyrate
CAS Number: 60-01-5
Synonyms: Glyceryl tri-n-butyrate, Butanoic acid, glycerol ester
Recommended Use: Laboratory chemicals, industrial processing, food additive, pharmaceutical applications
Supplier: Name, address, and emergency phone number available on purchase documentation or shipping papers according to source region laws
Emergency Contact: Refer to regional emergency hotline (for example, CHEMTREC, +1-800-424-9300 in U.S.)
Classification: Not classified as hazardous under OSHA 29 CFR 1910.1200
Physical Hazards: Not flammable under normal handling conditions
Health Hazards: Low acute toxicity; may cause mild skin or eye irritation on contact; ingestion of large amounts may lead to gastrointestinal discomfort
Environmental Hazards: Not classified as hazardous to aquatic environments based on available data
Label Elements: No pictogram or signal word required, but standard safe handling and personal hygiene practices advised
Precautionary Statements: Avoid direct eyes and skin contact, avoid inhalation of vapor or mist, wear suitable PPE during handling
Chemical Name: Tributyrin
CAS Number: 60-01-5
EC Number: 200-451-0
Concentration: 98%–100%
Impurities: Trace amounts of mono- and diglycerides possible, do not contribute to overall hazard
Additives: None reported
Inhalation: Move exposed person to fresh air, seek medical attention if symptoms such as coughing or shortness of breath develop
Skin Contact: Wash affected skin with soap and water, remove contaminated clothing; medical attention for persistent irritation
Eye Contact: Rinse eyes with water for several minutes, remove contact lenses, seek medical attention if irritation continues
Ingestion: Rinse mouth with water; do not induce vomiting, consult medical professional if large amount swallowed or symptoms appear
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, or foam
Unsuitable Extinguishing Media: Do not use high pressure water stream that could spread burning liquid
Specific Hazards: Decomposition can emit acrid smoke, carbon monoxide, and carbon dioxide
Personal Protective Equipment: Wear self-contained breathing apparatus, full protective gear recommended in case of major fire
Special Procedures: Cool containers with water spray from safe distance to prevent pressure build-up or rupture
Personal Precautions: Wear protective gloves, goggles, and clothing to avoid skin/eye contact; ensure adequate ventilation
Environmental Precautions: Contain spill to avoid entry into waterways, drains, or soil; prevent contamination of ground and surface water
Methods for Clean-Up: Soak up with inert absorbents (sand, earth, vermiculite), collect in labeled leak-proof containers for disposal; clean residual area with detergent and water
Reporting: Notify authorities as required by local, regional, and national regulations
Handling: Avoid inhalation of vapor or mist, wear recommended PPE (gloves, goggles, laboratory coat); wash hands thoroughly after handling, prevent spills and splashes
Storage Conditions: Store in tightly closed original container below 30°C (86°F), away from heat sources and incompatible materials (strong oxidizers, acids)
Incompatibilities: Strong oxidizing agents, strong acids
Packaging Materials: Compatible with glass, high-density polyethylene, stainless steel containers
Occupational Exposure Limits: No specific national or international exposure limits established
Engineering Controls: Use in a well-ventilated area, employ local exhaust ventilation when handling bulk amounts
Personal Protection: Nitrile or latex gloves for prolonged exposure, safety goggles for splash risk, lab coat or chemical-resistant apron; use approved respirator if ventilation is poor or aerosol generation expected
Hygiene Practices: Avoid eating, drinking, and smoking during use; frequent handwashing recommended
Appearance: Clear, oily liquid
Odor: Faint, buttery or fruity
Odor Threshold: Not determined
pH: Not applicable (practically insoluble in water)
Melting Point/Freezing Point: -75°C (-103°F)
Boiling Point: 305°C (581°F) at 101.3 kPa
Flash Point: 183°C (361°F) (closed cup)
Evaporation Rate: Negligible
Flammability: Not flammable at room temperature
Vapor Pressure: 2.6 x 10-4 mmHg at 25°C
Vapor Density: Not established
Relative Density: 1.03–1.06 (water = 1) at 20°C
Solubility: Slightly soluble in water, miscible with ether and alcohol
Partition Coefficient n-octanol/water: Log Kow ≈ 4.22
Auto-Ignition Temperature: 386°C (727°F)
Decomposition Temperature: Above 220°C, forms acrid fumes
Viscosity: 29–32 mPa·s at 25°C
Chemical Stability: Stable under normal temperatures and recommended handling conditions
Reactivity: Not reactive under normal use conditions
Incompatible Materials: Oxidizing materials, strong acids
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, acrolein under fire or thermolysis
Polymerization: Does not occur
Acute Toxicity: Oral LD50 (rat): >5000 mg/kg; low hazard by ingestion in laboratory animals
Skin Corrosion/Irritation: May cause mild, reversible irritation on prolonged skin contact
Eye Damage/Irritation: Mild, temporary irritation possible
Respiratory Irritation: Mist or vapor may cause coughing and discomfort
Sensitization: No evidence of sensitization in laboratory studies
Mutagenicity and Carcinogenicity: No evidence of mutagenicity, carcinogenicity, or reproductive toxicity in available studies
Repeated Dose Toxicity: No adverse effects seen in dietary studies in animals over several weeks
Toxicity to Aquatic Life: Very low acute toxicity expected; 96h LC50 (fish): >100 mg/L
Persistence and Degradability: Readily biodegradable in standard aerobic tests (OECD guidelines demonstrate breakdown in soil/water)
Bioaccumulative Potential: Moderate potential for bioaccumulation (Log Kow > 4)
Mobility in Soil: Low, due to limited water solubility and high partition coefficient
Other Adverse Effects: None identified in environmental studies
Waste Disposal Methods: Dispose in accordance with local, regional, and national environmental regulations; incineration preferred if permitted
Waste Code: Non-hazardous under RCRA (U.S.); follow local rules for oily organic liquids
Container Disposal: Triple-rinse, then recycle or dispose of in qualified facility; remove identifying labels before recycling
Precautions: Do not pour into drains, surface water, or soil
UN Number: Not regulated under ADR, IMDG, or IATA for road, sea, or air transport
Proper Shipping Name: Tributyrin, not dangerous goods
Transport Hazard Class: None assigned
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Special Transport Precautions: Avoid excessive heat and direct sunlight; keep container upright and securely closed during transit
Inventory Status: Listed in TSCA (U.S.), EINECS (EU), DSL (Canada), AICS (Australia), ENCS (Japan), other major inventories
GHS Labeling: Not required as hazardous under current GHS criteria
SARA Title III: Not subject to reporting under Sections 302, 304, or 313
California Proposition 65: Product not known to contain substances listed
REACH Status (EU): Registered, polymer exemption or pre-registered as required
Other Regulatory Remarks: Not subject to specific workplace exposure limits or restrictions under major international regulations
