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Product Name: Butafosfan
Synonyms: Tetrahydroxybutylphosphonium phosphate, Butafosfan Injection
Chemical Formula: C7H18O2P
CAS Number: 17316-67-5
Recommended Use: Veterinary injectable solution to support metabolism in animals, often administered for phosphorus deficiency
Manufacturer/Supplier: Refer to shipment label or regulatory documentation from supplier
Emergency Contact: Emergency medical services or local poison control center
Product Description: Clear, colorless to slightly yellow liquid with negligible odor, used commonly in veterinary medicine for its metabolic effects
Product Code: Reference supplier or packaging for code information
GHS Classification: Not classified as hazardous under GHS; always consult latest regulatory listings
Main Risks: Mild irritation possible on contact with eyes or skin; ingestion may cause gastrointestinal discomfort such as nausea or vomiting; inhalation in high concentrations may cause mild respiratory irritancy
Signal Word: None required, based on acute toxicity data
Pictograms: None required
PPE (Personal Protective Equipment): Standard laboratory gloves, splash goggles, lab coat
Precautionary Statements: Avoid direct contact with skin and eyes; prevent ingestion or inhalation during handling; maintain adequate ventilation during transfer and preparation; follow good hygiene practices after handling
Symptoms of Exposure: Redness, itching, mild irritation to skin or eyes, mild respiratory discomfort if inhaled
Component: Butafosfan
Chemical Name: Butylphosphonic acid anhydride
Concentration: 10% in most injectable veterinary formulations, with remaining composition being sterile water
Impurities: Trace sodium chloride and excipients, based on specific veterinary preparation specifications
CAS Registry Number: 17316-67-5
Other Ingredients: Sterile water for injection (CAS 7732-18-5), potential stabilizers depend on formulation
Inhalation: Move individual to fresh air, get medical attention if symptoms persist. Symptoms typically resolve shortly.
Skin Contact: Remove contaminated clothing, rinse affected skin with soap and water. Seek medical attention if irritation or allergic response develops.
Eye Contact: Rinse eyes slowly and gently with plenty of water for at least 15 minutes, keeping eyelids open. Obtain medical attention if irritation continues.
Ingestion: Rinse mouth thoroughly, seek prompt medical attention. Do not induce vomiting unless instructed by medical professionals.
Advice for Physicians: Treat symptomatically, monitor vital signs, provide supportive therapy for allergic or respiratory symptoms
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: High-powered water jet may spread liquid contamination
Hazardous Combustion Products: Phosphorus oxides, carbon monoxide, carbon dioxide
Special Precautions: Wear full protective gear including self-contained breathing apparatus; stay upwind of fire and prevent runoff
Flammability: Product itself is not highly flammable but may support combustion of other materials
Explosion Risk: None identified in typical use or storage conditions
Personal Precautions: Wear gloves, goggles, lab coat or protective suit. Limit access to area.
Environmental Precautions: Prevent product from entering drains, surface water, soil or groundwater; contain spills with inert absorbent material like sand or vermiculite
Clean-Up Methods: Absorb liquid spills with inert materials, place in labeled chemical waste container. Wash contaminated area with soap and water after clean-up.
Disposal Considerations: See Disposal Considerations section; ensure all waste is managed according to local guidelines
Handling: Use in well-ventilated area, avoid direct contact with eyes, skin, or clothing. Practice good hygiene by washing hands after use. No eating, drinking, or smoking during handling.
Storage Conditions: Store in tightly closed original container, in a cool, dry, dark, and well-ventilated area, away from incompatible chemicals like strong oxidizers.
Temperature Recommendations: Between 15°C and 25°C (59°F–77°F). Avoid freezing and excessive heat.
Incompatibilities: Strong oxidizing or reducing agents. Prevent contact with foodstuffs and animal feed.
Recommendation: Segregate from chemicals that could cause dangerous reactions.
Engineering Controls: Provide local exhaust ventilation if risk assessment suggests high exposure levels; otherwise, general room ventilation is typically sufficient
Respiratory Protection: If risk of vapor or aerosol exposure exists, use appropriate respirator or mask certified for chemical vapors
Eye Protection: Chemical splash goggles or face shield
Skin Protection: Impermeable gloves such as nitrile, lab coat or coveralls
Hygiene Measures: Change contaminated clothing immediately, wash hands thoroughly, avoid touching face during use
Occupational Exposure Limits: No specific TLV or occupational limit established for butafosfan; use good industrial hygiene practices
Appearance: Clear, colorless to slightly yellow liquid
Odor: Odorless or very faint odor
pH: 7.0 to 8.0 (aqueous solution)
Boiling Point: Approx. 100°C
Melting Point: Not available; product is a liquid at room temperature
Solubility: Completely soluble in water
Density: 1.025–1.065 g/cm³ (at 20°C)
Vapor Pressure: Not significant at room temperature
Flash Point: Not flammable
Viscosity: Comparable to water; low viscosity
Partition Coefficient: Not determined; biologically active in aqueous phase
Chemical Stability: Stable if stored in tightly sealed container at recommended conditions
Conditions to Avoid: Extreme temperatures, direct sunlight, high humidity, contamination with incompatible substances
Incompatible Materials: Strong oxidizers, strong acids, reducing agents
Hazardous Decomposition Products: Phosphorus oxides, carbon dioxide, carbon monoxide on combustion
Polymerization: No hazardous polymerization reported
Reactivity: Product remains stable under ordinary conditions; non-reactive unless in contact with strong oxidizing agents
Acute Toxicity: LD50 (oral, rat): >2,000 mg/kg, low acute toxicity
Dermal Toxicity: No significant toxic effects in animal studies after skin exposure
Inhalation Toxicity: Negligible risk under normal handling; aerosol or vapor exposure may cause transient discomfort
Skin Irritation: Mild, transient redness or dryness possible
Eye Contact: Minor, temporary irritation possible with direct exposure
Chronic Effects: No evidence of long-term toxicity or carcinogenicity from available data
Sensitization: Not reported as a sensitizer
Other Information: Not classified as a reproductive toxin or teratogen; always observe good lab safety practices regardless of hazard severity
Ecotoxicity: Limited data, aquatic toxicity considered low due to rapid dilution and breakdown in the environment
Persistence and Degradability: Expected to biodegrade rapidly in soil and aqueous environments
Bioaccumulation Potential: Not expected to bioaccumulate or persist in biological systems
Mobility in Soil: High solubility in water tends to lead to ready dispersion, low retention in soil
Additional Ecological Data: Avoid intentional disposal into waterways to protect aquatic organisms; environmental risk grows with concentrated or large-volume accidental releases
Precautionary Recommendations: Limit environmental release, follow local water discharge and waste management guidelines
Waste Disposal Methods: Dispose of product and contaminated materials in accordance with local, regional, and national regulations.
Packaging Disposal: Empty containers should be triple rinsed before disposal; do not reuse packaging.
Environmental Caution: Do not flush into sewer, soil, or surface water; keep waste streams separated for proper hazardous waste processing.
Safe Practices: Label disposal containers clearly, maintain waste documentation for regulatory checks, and schedule regular hazardous waste collection with licensed disposal services
UN Number: Not regulated for transport under UN, ADR, IATA, IMDG classifications
Transport Hazard Class: Not classified as dangerous or hazardous for road, rail, sea, or air
Packing Group: Not assigned
Marine Pollutant Status: Not a marine pollutant under present guidelines
Special Precautions for User: Secure containers upright during transport, avoid rough handling or exposure to extreme temperatures. Provide emergency contact details in transit paperwork.
Shipping Name: Butafosfan Solution (non-hazardous)
International Inventories: Registered in compliance with most global veterinary product regulations
US Federal Regulation: Not listed by OSHA, SARA, or CERCLA as a hazardous substance
EU Regulation: Meets requirements under REACH for veterinary use; not a classified substance under CLP Regulation
Canadian Regulation: Canadian DSL/NDSL compliant; not a WHMIS controlled product
Other Regulation: Always follow local, national, or international workplace health and safety, packaging, and veterinary product approval requirements
Label Requirements: Veterinary application only, not for human use, storage safeguards and emergency contact supplied on primary labels
