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Product Name: Biotin
Chemical Name: D-Biotin
Synonyms: Vitamin H, Coenzyme R
CAS Number: 58-85-5
Recommended Use: Dietary supplement, laboratory reagent
Supplier: Contact details available from the manufacturer
Emergency Phone: Refer to local poison control or manufacturer’s help desk
GHS Classification: Not classified as hazardous
Signal Word: Not required
Hazard Statements: Material does not meet criteria for classification as hazardous
Precautionary Statements: Avoid inhalation of dust. Minimize skin and eye contact. Practice good industrial hygiene.
Potential Health Effects: May cause mild irritation on contact with eyes or skin; ingestion of large amounts could possibly lead to digestive discomfort.
Environmental Hazards: No known significant environmental hazards.
Chemical Name: Biotin
CAS Number: 58-85-5
Percent (%): ≥ 98% (commercial preparations typically contain minimal excipients)
Impurities: Trace amounts of related substances possible depending on manufacturer
Inhalation: Move to fresh air, seek medical attention if symptoms persist such as cough, dizziness, or shortness of breath.
Skin Contact: Wash affected area with soap and water; if irritation or rash develops, get medical advice.
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes, lift eyelids to flush thoroughly; get medical attention for persistent discomfort.
Ingestion: Rinse mouth with water, obtain medical attention if feeling unwell or large amounts swallowed.
Most Important Symptoms/Effects: Slight irritation possible, no known acute or chronic toxicity under normal conditions.
Medical Attention and Special Treatment: Symptomatic treatment only.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Media: Avoid high-pressure water streams which may spread powder
Hazardous Combustion Products: May include carbon oxides, nitrogen oxides, and sulfur oxides
Special Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective clothing
Specific Hazards: Dust can form explosive mixtures with air, handle powders carefully to reduce dust formation
Firefighting Instructions: Use water spray to cool containers exposed to fire, avoid breathing smoke or vapors
Personal Precautions: Avoid breathing dust, ventilate area, use personal protective equipment such as gloves, goggles, and dust mask
Environmental Precautions: Prevent material from entering drains, sewers, or water bodies
Methods for Cleanup: Sweep or vacuum up material and place in a suitable container for disposal; minimize dust generation
Spill Response: Wash spill site after material pickup is complete
Handling: Avoid dust generation, wash hands after handling, ensure proper ventilation in work areas, do not eat, drink, or smoke while using product
Storage: Store in a tightly sealed container, keep in a cool, dry, well-ventilated place, protect from direct sunlight and moisture, temperature recommendations typically below 25°C
Incompatibilities: Strong oxidizers, strong acids or bases may affect stability
Hygiene Practices: Practice routine good housekeeping and hygiene
Occupational Exposure Limits: No occupational exposure limits established for Biotin
Engineering Controls: Use local exhaust ventilation to minimize airborne dust
Eye Protection: Safety goggles or face shield
Skin Protection: Chemical-resistant gloves, lab coats, or protective clothing
Respiratory Protection: Dust mask or respirator if dusty conditions are encountered
Work Practices: Avoid handling powder in the presence of ignition sources, wash exposed areas thoroughly after handling
Environmental Exposure Control: Prevent bulk entry into water systems
Physical State: White or off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Not determined in water (poor solubility)
Melting Point: 232°C–233°C (decomposes)
Boiling Point: Not determined, decomposes at high temperatures
Flash Point: Not available
Evaporation Rate: Not applicable
Flammability: Not highly flammable but can burn under fire conditions
Vapor Pressure: Negligible
Vapor Density: Not available
Relative Density: 1.3–1.4 (water = 1)
Solubility: Slightly soluble in water; soluble in hot water; soluble in alkali solutions; practically insoluble in most organic solvents
Partition Coefficient: log Pow -0.07 (estimated)
Auto-ignition Temperature: Not available
Decomposition Temperature: Above 233°C
Viscosity: Not applicable
Molecular Formula: C10H16N2O3S
Molecular Weight: 244.31 g/mol
Chemical Stability: Stable under normal conditions and storage recommendations
Reactivity: Non-reactive with common materials
Conditions to Avoid: High humidity, exposure to strong light, heat, or open flame
Incompatible Materials: Strong oxidizing agents, strong acids, or alkali
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, sulfur oxides on decomposition
Hazardous Reactions: No dangerous reactions known under recommended conditions
Acute Toxicity: Oral LD50 (rat) >10,000 mg/kg
Skin Corrosion/Irritation: No data indicating significant skin irritation
Serious Eye Damage/Irritation: Mild irritation may occur from dust contact
Respiratory Sensitization: Not classified as a respiratory sensitizer
Skin Sensitization: Not classified as a skin sensitizer
Germ Cell Mutagenicity: No available data suggesting mutagenic effects
Carcinogenicity: Not listed by IARC, ACGIH, NTP, or OSHA as a carcinogen
Reproductive Toxicity: No evidence of reproductive toxicity at nutritional exposures
Specific Target Organ Effects: No effects reported at normal levels; excessive exposure rarely reported to cause adverse effects
Aspiration Hazard: Not applicable due to physical form
Additional Information: Widely used in food and pharma products; well-tolerated at dietary doses
Ecotoxicity: No evidence of significant toxicity to aquatic organisms based on available data
Persistence and Degradability: Readily biodegradable in the environment
Bioaccumulative Potential: Low potential for bioaccumulation (log Pow -0.07)
Mobility in Soil: Limited data; likely moderate mobility associated with organic matter
Other Adverse Effects: None known, not identified as causing ozone depletion or significant environmental problems
Waste Disposal Methods: Dispose of contents in compliance with local, regional, and national regulations; avoid release into the environment
Contaminated Packaging: Triple rinse containers, offer for recycling or disposal with a licensed waste facility
Special Precautions: Do not incinerate in closed containers, do not dispose of in household trash if large amounts present
Regulatory Status: Typically not regulated as hazardous waste; always confirm with local legislation
UN Number: Not classified as dangerous goods
UN Proper Shipping Name: Not regulated for transport
Transport Hazard Class(es): None
Packing Group: None
Environmental Hazards: Not considered a marine pollutant
Special Precautions for Transport: Protect from moisture and excessive heat; ensure containers remain sealed to minimize dust release
Regulatory Status: Not subject to ADR, IMDG, IATA, or DOT regulations
OSHA Status: Not considered hazardous under US Occupational Safety and Health Administration (OSHA) regulations
TSCA Status: Listed on the US Toxic Substances Control Act (TSCA) Inventory
SARA Title III: Not subject to SARA 302, 304, 311/312, or 313 reporting requirements
California Proposition 65: Not listed as a substance known to cause cancer or reproductive toxicity
WHMIS (Canada): Not controlled product
REACH Status (Europe): Listed or exempt from registration; verify supplier’s REACH compliance
Other Regulatory Notes: FDA recognized as dietary ingredient (food, supplements); pharmaceutical grade product must adhere to pharmacopeial standards
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
