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Product Name: Bifidobacterium longum
Synonyms: B. longum, probiotic microorganism
Recommended Use: Dietary supplement, probiotic ingredient, microbiota research
Company Details: Manufacturer and distributor contact information available on packaging
Emergency Contact: Refer to supplier; local poison control center for accidental exposure
CAS Number: 15697-26-0
Formula: Not applicable (microbial culture, not a chemical compound)
Classification: Not classified as hazardous under GHS criteria
Main Hazards: Non-pathogenic in healthy individuals; immunocompromised individuals may face infection risk after inhalation or ingestion
Label Elements: No official hazard pictogram, warning, or signal word required by standard regulations
Health Effects: May irritate eyes, skin, or respiratory tract in sensitive people
Environmental Impact: Little to no known toxic impact according to available studies
Component: Bifidobacterium longum (live or lyophilized cells)
Component Concentration: 5 × 109 - 5 × 1011 CFU/g typical in commercial powder
Carrier Materials: Maltodextrin, lactose, skim milk powder—percentages vary by supplier
Impurities: Trace protein, carbohydrate, moisture from fermentation
Ingredient Purity: Typically ≥95% identified viable cell content
Inhalation: Remove exposed person to fresh air; seek medical attention if respiratory discomfort persists
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing if irritation occurs
Eye Contact: Rinse immediately with water for at least 15 minutes; consult medical professional if irritation continues
Ingestion: Rinse mouth; not expected to cause adverse effects for healthy individuals; monitor and consult physician if symptoms arise
Symptoms: Redness, irritation, cough possible, particularly in sensitive or immunocompromised persons
Suitable Extinguishing Media: Water, CO2, foam, or dry chemical extinguisher
Special Hazards: Organic dust can form explosive mixtures with air in rare, poorly ventilated storage
Protective Equipment: Standard firefighting gear: gloves, goggles, positive-pressure self-contained breathing apparatus
Combustion Products: May release carbon monoxide, carbon dioxide, nitrogen oxides, trace volatile organic compounds
Personal Precautions: Avoid breathing dust, use proper protective gear such as gloves, mask, goggles
Spill Cleanup: Moisten powder to limit airborne spread; sweep up and collect in closed containers for disposal
Environmental Precautions: Prevent large amounts from entering water systems; bacteria can disrupt natural microbial balance if discharged in heavy concentration
Surface Decontamination: Clean thoroughly with soap and water; avoid dry sweeping to minimize dust
Handling: Use with adequate ventilation; avoid inhalation and direct contact; do not eat, drink, or smoke during handling
Technical Measures: Work in clean, controlled areas; consider HEPA filtration in production
Storage Conditions: Store in original, sealed container at 2–8°C (refrigerated); avoid moisture and direct sunlight
Incompatible Materials: Do not store with strong acids, strong oxidizers, or high humidity
Packaging Materials: Use airtight, food-grade containers; avoid permeable plastics in humid environments
Occupational Exposure Limits: None established for B. longum
Engineering Controls: Local exhaust ventilation or containment recommended for large-scale handling
Personal Protective Equipment (PPE): Disposable gloves, laboratory coat, eye protection, dust mask or P3 respirator for powder
Hygiene Measures: Wash hands after use; keep work clothing separate from street clothing; avoid hand-to-mouth contact in work area
Environmental Controls: HEPA filtration, surface disinfection with suitable bactericidal solution
Appearance: Fine, off-white to beige powder
Odor: Faintly dairy, sometimes sour
pH (10% suspension): 5.5–7.5
Solubility: Disperses in water; inactive residues remain suspended
Bulk Density: 0.2–0.5 g/cm3
Melting Point: Not applicable
Boiling Point: Not applicable
Explosive Properties: Dust may be combustible under specific conditions
Chemical Stability: Stable under recommended storage conditions
Conditions to Avoid: High heat, moisture, exposure to sunlight, air exchange; improper closure of packaging
Materials to Avoid: Strong acids, strong oxidizers, caustic agents
Hazardous Reactions: No known dangerous reactions
Decomposition Products: Breakdown creates organic residues and gases
Acute Toxicity: Not known to cause toxic effects in healthy individuals
Chronic Effects: No chronic toxicity reported in literature for standard ingestion
Allergenicity: Individuals with milk allergy may react to carrier matrix (such as lactose or skim milk powder)
Routes of Exposure: Inhalation may cause symptoms in sensitive people; ingestion typically harmless, but may be harmful to the immunocompromised
Carcinogenicity, Mutagenicity, Reproductive Toxicity: Not classified, no evidence of risk
Sensitization: Low probability unless carrier or excipient is a known allergen
Ecotoxicity: Risk to aquatic and terrestrial environments is low, natural soil/intestinal microorganism
Mobility in Soil: Limited migration; survives poorly outside host or laboratory conditions
Persistence: Returns to natural baseline levels without noticeable impact
Bioaccumulation: Not expected to accumulate in food chain
Other Adverse Effects: No significant harmful impact documented in public scientific resources
Waste Generation: Dispose of in accordance with local, regional, and national regulations
Product Disposal: Biological waste (autoclave, incinerate, or treat with disinfectant before landfill)
Packaging Disposal: Rinse, if possible, before recycling; treat as laboratory waste if heavily contaminated
Precautions: Avoid uncontrolled discharge to drain or watercourses
UN Number: Not classified as dangerous goods for transport
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Labeling Requirements: None required beyond standard supplier labeling
Special Precautions: Store and transport refrigerated to maintain viability; minimize exposure to shocks, pressure, or moisture
Handling During Transport: Seal containers well; keep upright and avoid crushing or piercing packaging
Global Regulatory Status: Generally Recognized as Safe (GRAS) for food applications in many regions
OSHA: Not listed as a hazardous substance
TSCA: Registered by manufacturers as microbial commercial product
EU Regulations: Bifidobacterium longum is approved as a novel food ingredient, subject to member state notifications
Other Standards: Complies with ISO and FAO/WHO probiotic safety standards, as documented in technical dossiers; labeling must follow national probiotic guidelines
Label Claims: Efficacy, health claims, and shelf life must be substantiated and approved by local regulatory authorities before market release
