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Bifidobacterium Animalis: Story, Science, and Opportunity

Historical Development

More than a century of research has turned this humble bacterium into a cornerstone of modern probiotic science. French microbiologist Henri Tissier discovered the first strains from a healthy breastfed baby early in the 20th century, kicking off a wave of curiosity about gut health and bacteria. Through the mid-to-late 1900s, the drive for safer, natural fermenters for dairy production sparked focused trials with Bifidobacterium animalis. Culture collections and identification techniques matured, especially with advances in molecular biology. This species, with its noted stability and compatibility with industrial processes, slowly took the lead in commercial products, setting new expectations for quality control and reliability.

Product Overview

Supermarkets now overflow with foods, dietary supplements, and even animal nutrition additives using Bifidobacterium animalis. Consumers sort through names like BB-12 or DN-173 010, more familiar from yogurt labels than from scientific lists. Branding from companies such as Chr. Hansen or Danisco has helped put this probiotic on the public’s radar. Many of these products tout immunity and digestive regularity as key benefits. Product developers rely on its resilience through processing and storage, which appeals to manufacturers looking for shelf-stable and predictable cultures in their lines.

Physical & Chemical Properties

This bacterium appears as Gram-positive, rod-shaped cells. Its colonies start out creamy to white on selective agar, a sign it can flourish in both human guts and industrial tanks. Bifidobacterium animalis thrives at around 37°C, with a pH drop signaling lactic and acetic acid generation, key to maintaining a healthy microflora. It resists oxygen slightly better than its cousins, but still prefers low-oxygen, nutrient-rich environments. Its stability marks a big technical win—proteins and cell walls stay intact under moderate heat and air exposure, so it survives many food matrices better than other bifidobacteria.

Technical Specifications & Labeling

Accurate strain names carry weight in the probiotics realm. Labels require the full binomial name plus strain ID for credibility and traceability. Labels in the US or EU must indicate live CFU (colony-forming units) count at end-of-shelf-life, not at manufacture. Regulators also want allergen and storage information spelled out clearly, including refrigeration needs. Specifications usually cover moisture content, viable count, and absence of common contaminants such as Salmonella and Staphylococcus aureus. Companies list these details in Certificates of Analysis, which must match on-packed labeling.

Preparation Method

Factories start with a single colony, multiply it in rich fermentation media, and ramp up culture volumes to large stainless tanks. Once the bacteria finish fermenting, teams harvest and concentrate them—usually through centrifugation—then mix with cryoprotectants like skim milk powder or trehalose. Next comes freeze-drying, which locks cells into a dormant, shelf-stable form. Labs keep master cell banks stored at -80°C for traceability and rapid replenishment. No secret sauce here, just rigor and tight environmental controls to limit unwanted microbes and genetic drift.

Chemical Reactions & Modifications

Inside the gut, Bifidobacterium animalis gets to work fermenting oligosaccharides, fibers, and sometimes sugars like lactose. The main end-products are lactic and acetic acids, which lower intestinal pH and keep many pathogens at bay. Some strains help break down resistant starches, giving an extra advantage to hosts with less efficient digestion. Geneticists sometimes tweak strains to improve acid or oxygen resistance—it’s a tricky road, facing both technical limits and regulatory scrutiny. For most products, modifications stay within the range of natural strain selection and adaptive training, rather than genetic engineering.

Synonyms & Product Names

In research, Bifidobacterium animalis goes by several tags. Subspecies such as B. animalis subsp. lactis and B. animalis subsp. animalis trace back to strain-level genetic differences. Food companies stick with trade names like BB-12, DN-173 010, or BLC1, each pointing to a deposit in an international culture bank. Researchers and product managers need this clarity. Strain-to-strain differences in immune stimulation or survival rates call for precise naming to avoid misleading health claims.

Safety & Operational Standards

Safety sits at the top for any probiotic used in food or supplements. Decades of studies show Bifidobacterium animalis rarely causes harm in healthy people, meeting Qualified Presumption of Safety status in the EU and GRAS recognition in the US. Probiotic production happens in near-surgical clean rooms with frequent batch testing for pathogens and toxin genes. Teams pull regular environmental samples around their facilities, keeping an eye out for unexpected cross-contamination. Documentation at every step—strain origin to fermentation logs—supports safety audits and recall readiness.

Application Area

Manufacturers add Bifidobacterium animalis to everything from infant formula to cultured milks, soft cheeses to meal replacement bars. Its role in non-dairy beverages and plant-based foods is picking up, especially where brands chase digestive health benefits. In veterinary and pet health, some products address issues like diarrhea in puppies or foals, using this bacterium’s track record for gentle restoration of gut flora. Food processors value its resilience during pasteurization or storage, translating to fewer rejected batches and longer-lasting activity in the final product.

Research & Development

Academic labs and industry consortia keep refining ways to define genetic stability, survivability in simulated digestion, and precise health effects. Human clinical trials now focus on conditions like irritable bowel syndrome, travel-related discomfort, or even mood modulation through the gut-brain axis. Metagenomic sequencing reveals how this bacterium interacts with the entire microbiome, sparking ideas for custom blends or even “precision probiotics.” Teams exploring feedstocks beyond dairy, such as oat milk or pea protein, work to find the right balance of food technology and biological performance.

Toxicity Research

Bifidobacterium animalis stands out for its absence of toxin production in published toxicological screens. Animal models rarely show side effects outside of rare, extreme immune suppression. Surveillance in hospital settings, especially with vulnerable patients, tracks any incidence of sepsis or adverse reaction, but numbers remain negligible. Regulators demand full reporting of safety data from both industry-funded and independent trials, resetting allowable intake levels and usage limits if new evidence emerges. Vigilance continues, reinforced by stricter post-market monitoring programs in major countries.

Future Prospects

The field buzzes with plans to push Bifidobacterium animalis into new territories—both in products and science. As consumers ask tougher questions about microbiome effects on whole-body and mental health, researchers explore tailored synbiotic combinations, pairing this bacterium with specific dietary fibers. Teams build improved delivery systems that target the colon more reliably. In genetic research, greater insight into host-microbe interactions suggests the future will bring regulatory pressure to document each probiotic strain’s precise actions. This push nudges companies toward full genomic transparency, pushing research data directly onto labels and promotional material. As climate, supply chains, and consumer expectations shift, this one-time humble gut neighbor keeps earning its marquee spot in health and nutrition.




What are the health benefits of Bifidobacterium animalis?

Simple Science Behind Bifidobacterium animalis

Bifidobacterium animalis sounds like a mouthful, but it’s one of the stranger helpers in our digestive tracts. Years ago, I started paying attention to probiotics after battling stomach cramps and inconsistent “gut feelings”—literally. Bifidobacterium animalis happens to be a well-studied strain in the world of gut microbes. Most folks know probiotics help digestion, but Bifidobacterium animalis has some perks that go beyond the basics.

Gut Balance Makes Life Smoother

Bloating, irregularity, and that nagging discomfort usually point to an off-kilter gut population. Bifidobacterium animalis shines in putting our gut flora back in order. The strain’s been studied in products like Activia yogurt, which I tried out daily for much of last year. What I found was less unpredictability in the morning—science backs this up with research showing improved stool regularity and transit time for folks adding this microbe to their diet. A study published in the World Journal of Gastroenterology found that individuals taking this probiotic experienced relief from constipation and a general improvement in bowel movement patterns.

Strengthening Your Defenses

Gut health and immune strength go hand in hand. Over 70% of our immune activity sits in the gut, so a sturdy microbial army keeps the bad bugs at bay. Bifidobacterium animalis bolsters that defense. I rarely got colds the winter I started eating probiotic yogurt, and a meta-analysis in the journal Beneficial Microbes pointed out that this bacteria can support immune response by reducing the risk of gut and respiratory infections. The research isn’t hype—these effects matter most for people with weaker immune systems or kids picking up every bug at school.

Digesting Dairy With Less Drama

Lactose intolerance causes a lot of discomfort for people who love milk but hate the after-effects. Bifidobacterium animalis helps break down lactose more efficiently, which means less grumbling after ice cream or pizza. Clinical trials show that participants who took this probiotic before dairy meals saw fewer symptoms like cramping and bloating. If you’re sensitive to dairy, making this microbe part of your routine might ease some of the frustration.

Supporting Mental Clarity and Mood

Science moves slowly in linking gut health to brain function, but it doesn’t take much to notice how a troubled stomach drags down the mood. Studies published in Frontiers in Psychiatry have examined the “gut-brain axis” and highlighted how a steady supply of Bifidobacterium animalis may support reductions in stress and improved mood balance. My own experience suggests that better digestion leads to fewer distraction headaches and foggy days.

Toward Everyday Solutions

Adding more live cultures like Bifidobacterium animalis comes down to eating more probiotic-rich foods. Yogurt, kefir, and fortified drinks are simple options. Homemade yogurt and fermented vegetables work just as well, as long as the label mentions specific strains. For those who shy away from dairy, non-dairy probiotic supplements offer a similar boost. Always check product labels and consult a healthcare provider before making major changes, especially for individuals with chronic health issues. Regular consumption pays off only with consistency, not sporadic splurges.

Is Bifidobacterium animalis safe for daily consumption?

What Bifidobacterium animalis Does in Food and the Body

Bifidobacterium animalis shows up in many probiotic yogurts, drinks, and supplements at the store. Heartburn, bloating, and diarrhea bring people to the pharmacy. Companies promise benefits like a stronger gut and smoother digestion. Research over the last two decades covers the ways this microbe supports that cause. The World Health Organization defines probiotics as living organisms that, when taken in the right amounts, support health. Major yogurt brands choose B. animalis subsp. lactis for a reason. Studies suggest this strain resists stomach acid, so it sticks around longer and reaches your intestines alive. That means a real shot at rebalancing gut bacteria after stress, travel, or antibiotics.

Researchers from Finland and the United States tested the ability of B. animalis to reduce the duration of diarrhea in children and adults. Their studies found reduced episodes in those given yogurt or supplements compared to people without it. Researchers in the Netherlands documented moderate benefits for people with irritable bowel syndrome. Shoppers read labels promising immune system support as well. A review from “Nutrients” in 2022 backed the idea that B. animalis may help reduce inflammation by nudging immune cells with molecules called short-chain fatty acids.

Looking for the Downsides

Some people feel suspicious reading “bacteria” on a food label. Research has set consumers’ minds at ease. Healthy adults and children have taken B. animalis—sometimes by the billions of colony-forming units—every day. No studies turned up dangerous effects or toxic reactions when used this way, even for months on end. The European Food Safety Authority, the FDA, and Health Canada recognize this species as safe for general use in food. Outliers exist. Anyone with a significant immune system problem or severe illness may need tighter guidance from a doctor, since any “good” bacteria in very rare cases could cause issues.

Side effects rarely crop up for the average person. A handful of users report gas or mild bloating after starting probiotics such as B. animalis, but this fades for most folks after a week or two. Ingredients blended with the probiotics (like sweeteners or added fibers) show up far more often in consumer complaints than the bacteria themselves.

Sifting Through Claims and Making Choices

Product labels carry bold promises about gut balance and digestion. Many companies use clinical terms, but individual reactions vary. B. animalis appears in successful studies, but not everyone feels better immediately. No yogurt or pill takes the place of meals rich in fiber, vegetables, and whole grains. Bacteria need food to flourish—without prebiotics, probiotics eventually run out of fuel. I often try to remind friends who ask about gut health that a routine menu of fresh produce brings as much benefit as any daily bottle.

Smart Habits and Gut Health Solutions

Adding a cup of probiotic yogurt won’t make up for poor eating or little sleep. Real improvements in digestion usually arrive when probiotic foods join a line-up with fiber-rich snacks, less sugar, plenty of water, and a good stretch of sleep. Safe probiotic use also means reading ingredient lists and avoiding megadoses. Science supports B. animalis daily for most people who eat a typical Western diet, but it pays to monitor how your body feels, talk with a professional before major changes, and avoid multitasking with several new supplements at once.

Does Bifidobacterium animalis help with digestion or gut health?

Reality Check on Bifidobacterium animalis

Walk down any supplement aisle and you’ll hit a parade of probiotic bottles. Bifidobacterium animalis pops up on plenty of those labels. Scientists first isolated this friendly bacterium from dairy products, and it’s still widely added to yogurt and kefir. All those claims about smoother digestion and happier guts sound great. Yet, the real world keeps trying to pull us back to earth. Not everything that looks good on packaging translates to magic inside the body.

Does This Bacteria Change the Digestion Game?

After reading a fair share of research and watching trends, people tend to believe Bifidobacterium animalis can offer relief from problems like bloating or irregularity. Studies on folks with constipation report some improvement after taking supplements containing this strain. In my own life, after a round of antibiotics left my system in chaos, a carton of yogurt with Bifidobacterium animalis did seem to bring some relief. My digestion smoothed out and stomach grumbles lessened. That felt like proof, but not everyone notices major changes, and the effect can depend on personal gut chemistry.

Looking beyond personal stories, multiple studies point out this bacterium tends to survive the harsh conditions in the stomach, making it all the way to the large intestine, where it gets down to work. Once there, it helps break down fibers in foods and can crowd out less helpful bacteria. The body in turn cranks out more short-chain fatty acids, which nutrition experts tie to less inflammation and a tighter gut barrier. This all makes a pretty strong case for having a community of beneficial bacteria.

The Science Behind the Hype

It feels smart to keep expectations in check. The European Food Safety Authority found enough human and animal evidence to consider Bifidobacterium animalis a safe option for general use. Doctors often point out that, while it helps some people deal with mild digestive issues, it won’t cure deeper gut trouble on its own. Reviews in journals like Beneficial Microbes report that combinations of probiotics often outshine single-strain supplements. Adding in some fiber or “prebiotic” foods—like bananas, oats, or garlic—makes probiotics like Bifidobacterium animalis work better and stick around longer inside the gut.

Food quality can change how well probiotics work. Live cultures in yogurt or fermented vegetables often do more for the body than a shelf-stable capsule. The U.S. National Institutes of Health points out that not all products live up to their promises. Some don’t hold enough live cultures by the time you eat them, while others drop off fast if stored at room temperature.

What’s the Takeaway for Everyday Gut Health?

The modern diet, loaded with ultra-processed food and low in natural fiber, leaves many guts in rough shape. Adding in foods rich in Bifidobacterium animalis might ease mild issues and support a more robust digestive system but won’t fix everything. Acting on the advice of a registered dietitian or a doctor takes priority for anyone dealing with ongoing gut problems. Start by dialing up real, whole foods and look for yogurts boasting live cultures if you want to give this strain a shot.

Gut health shapes energy, mood, and even immunity. Building a thriving microbial community in the gut takes a steady supply of fermented foods, plenty of fiber, good hydration, and movement. Probiotics, including Bifidobacterium animalis, play a role—just not the starring one people sometimes hope for.

Are there any side effects of taking Bifidobacterium animalis?

Why People Turn to Probiotics

Gut health gets a lot of attention these days, and for good reason. Daily stress, antibiotics, processed foods, and changing diets can throw our digestive system out of balance. Bifidobacterium animalis, a probiotic found in some yogurts and supplements, promises a helping hand. Plenty of studies highlight its role in easing constipation, supporting regularity, and even helping with irritable bowel symptoms. Before adding any bacteria to your routine, questions about safety and side effects deserve answers grounded in real evidence and experience.

Common Side Effects: What You Might Notice

Most people don’t feel much at all—besides, perhaps, smoother digestion. Mild gas, bloating, and rumbling in the first few days show up for some. It’s a sign your gut bacteria are shifting, not necessarily a bad thing, though it can be uncomfortable. For folks starting a probiotic like Bifidobacterium animalis for the first time, slow and steady seems best. Large clinical studies, including one from the Journal of Clinical Gastroenterology, show these early symptoms tend to resolve in a week.

Serious side effects rarely come up for healthy adults. The American Gastroenterological Association and Mayo Clinic both note that for the average person, probiotics don’t introduce much risk. Most commercial supplements go through rigorous screening and quality tests, especially those found in mainstream yogurts and pharmacy shelves.

Who Needs to Watch Out?

Not everyone has the same experience. People with weakened immune systems, whether from chemotherapy, immune diseases, or recent surgery, need to talk to a doctor before jumping in. There have been sparse case reports where probiotics traveled from the gut and caused infections in vulnerable individuals. These cases stand out as exceptions, not the rule, but the message is clear: for some, expert guidance before trying Bifidobacterium animalis matters.

Ingredient Quality and Labeling Issues

One area worth calling out—quality control. Supplements sold in the U.S. aren’t always tested to the same standard as prescription drugs. A study published in Frontiers in Microbiology found some probiotic brands overstated their colony counts or mixed up the strains listed. That makes it harder for consumers to know what’s really inside the bottle. Choosing brands that use third-party testing or certifications, and seeking advice from a registered dietitian or pharmacist, cuts down on the risk of picking the wrong product or getting less than promised.

Can Beneficial Bacteria Cause Allergic Reactions?

Allergic reactions to probiotics rarely happen, but some people react to other ingredients in capsules or flavored yogurt, like dairy, soy, or gluten. Checking ingredient labels, especially for those with food sensitivities, matters just as much as picking the right bacterial strain.

Is Bifidobacterium animalis Worth It?

Doctors and dietitians point to growing evidence on the gut-brain connection and the overall role of certain probiotics in health. For most, the odds of running into trouble remain low. Listening to your body, starting with a lower dose, and staying in touch with your healthcare provider build confidence and cut down anxiety. Products change and new science emerges, so staying informed counts for a lot if you want your gut—and the rest of you—to work at its best.

How should Bifidobacterium animalis products be stored?

Why Storage Conditions Matter for Bifidobacterium animalis

Anyone who has spent time reading the label on a supplement bottle has probably wondered if all those instructions really make a difference. With probiotics like Bifidobacterium animalis, it becomes clear that storage is far from a marketing afterthought. This probiotic brings real benefits—for example, research in Frontiers in Microbiology points to improved digestive health and support for the immune system—but those benefits depend on keeping the bacteria alive until you need them.

Too often, people leave these supplements on the kitchen counter or in a steamy bathroom. Warm, humid environments create the perfect conditions for bacteria to lose viability. Studies from the International Probiotics Association report that improper storage drops the number of living cells in a product, and that means less benefit when you take them. Nothing feels worse than trusting a health product, only to find out it lost its punch because of simple mistakes at home.

Refrigeration: Friend or Foe?

Manufacturers often give mixed messages on whether refrigeration is necessary. Some products arrive in daily blister packs and claim to be shelf-stable. Others ask you to find a spot in the fridge right away. My own experience matches what experts recommend: unless a product package clearly says it can handle room temperature, better play it safe and store it in the fridge.

Cold slows down microbial activity. With Bifidobacterium animalis, that means a longer shelf life and a better shot at getting the advertised dose. According to published reviews from the Journal of Dairy Science, refrigerated storage keeps probiotic populations stable for months, allowing families to trust the contents inside their yogurt, capsules, or sachets.

Humidity and Light: Two Hidden Enemies

Refrigeration alone won't solve every problem. Just ask anyone who lives in a humid area—the inside of a fridge can be surprisingly damp. Some people, including myself, store probiotic capsules in the fridge door or in containers exposed to air every day. Moisture sneaks in and can ruin the whole batch. To avoid that, it helps to keep the container tightly sealed. Silica gel packs come with some products for a reason. Keeping them inside the bottle helps soak up extra moisture.

Light breaks down live bacteria. Transparent jars or bags let in more UV rays, which slowly reduce the live cell count. I always stick with brands that use dark glass bottles or foil blister packs, and I keep them away from direct sunlight—even inside the fridge.

What Works for Everyday Users

Most people don’t have the time or desire to become storage experts. Simple habits go a long way. I keep my probiotics on a middle fridge shelf, tightly sealed, away from food that might leak. For those who travel or need to take their supplements to work, buying smaller bottles means less time exposed to heat and light once opened. Remember, not every product is created equal; always check the storage info on the package and look for third-party seals showing the manufacturer’s commitment to potency.

Supporting Quality with the Right Choices

Probiotics promise a lot, but only live strains can deliver those health boosts. Choosing trusted brands, reading storage instructions, and taking simple steps to avoid heat, moisture, and light go a long way toward making sure Bifidobacterium animalis products work as promised. A little extra care in the fridge easily beats disappointment at the bottom of an ineffective pill bottle.

Bifidobacterium Animalis
Names
Preferred IUPAC name Bifidobacterium animalis
Other names Bifidobacterium lactis
Bifidobacterium animalis subsp. lactis
Pronunciation /ˌbɪf.ɪ.doʊ.bækˈtɪə.ri.əm ˌæn.ɪˈmæl.ɪs/
Preferred IUPAC name Bifidobacterium animalis
Other names Bifidobacterium animalis subsp. lactis
Bacillus bifidus
Bifidobacterium lactis
Bifidobacterium animalis DN-173 010
Bifidobacterium animalis BB-12
Bifidus
Pronunciation /ˌbɪf.ɪ.doʊ.bækˈtɪə.ri.əm əˈnɪm.ə.lɪs/
Identifiers
CAS Number ["9001-42-7"]
Beilstein Reference 3408310
ChEBI CHEBI:81132
ChEMBL CHEMBL1742953
ChemSpider 21591227
DrugBank DB15661
ECHA InfoCard 100000011072
EC Number EC 2.7.1.69
Gmelin Reference 23946
KEGG T01041
MeSH D044702
PubChem CID 25245574
RTECS number TD9610700
UNII 6K3W7V7Q3A
UN number UN3332
CompTox Dashboard (EPA) Bifidobacterium Animalis CompTox Dashboard (EPA) string: **DTXSID1022522**
CAS Number “115622-36-7”
Beilstein Reference 4279158
ChEBI CHEBI:83751
ChEMBL CHEMBL4298598
ChemSpider 21591055
DrugBank DB15661
ECHA InfoCard echa-info-card-100000000605
EC Number 322-415-1
Gmelin Reference 98198
KEGG T01039
MeSH D018895
PubChem CID 25250253
RTECS number TD9636680
UNII HN3W9445BG
UN number UN1993
Properties
Chemical formula C5H9NO4
Appearance White or off-white powder
Odor Odorless
Density 0.86 g/cm3
Solubility in water Soluble in water
log P 3.14
Acidity (pKa) 4.5
Basicity (pKb) 4.5
Magnetic susceptibility (χ) Diamagnetic
Refractive index (nD) 1.345
Viscosity Viscous liquid
Dipole moment 0 D
Chemical formula C5H9NO4
Molar mass Bifidobacterium animalis is a bacterium, not a chemical compound, so it does not have a defined molar mass like small molecules.
Appearance White or off-white powder
Odor No characteristic odor
Density 0.08 g/cm3
Solubility in water Soluble in water
log P 2.7
Magnetic susceptibility (χ) −9.6 × 10⁻⁶ cm³/mol
Refractive index (nD) 1.335
Dipole moment 0 D
Pharmacology
ATC code A07FA01
ATC code A07FA03
Hazards
Main hazards No significant hazards identified.
GHS labelling GHS labelling for Bifidobacterium animalis: `"Not classified as hazardous according to GHS"`
Pictograms 'fermented-milk-products'
Signal word Warning
Hazard statements No known significant effects or critical hazards.
Precautionary statements IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
NFPA 704 (fire diamond) NFPA 704: 0-0-0
NIOSH Bifidobacterium animalis
PEL (Permissible) 10 mg/m³
REL (Recommended) 0.5-2 × 10^10 CFU
IDLH (Immediate danger) Not established
Main hazards May cause allergic reactions, respiratory irritation, or infection in immunocompromised individuals.
GHS labelling GHS labelling: Not classified as hazardous according to GHS.
Pictograms fermented-milk, milk
Signal word No signal word
Hazard statements Hazard statements: The product does not meet the criteria for classification in accordance with Regulation (EC) No 1272/2008.
Precautionary statements IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
NFPA 704 (fire diamond) NFPA 704: "Health: 0, Flammability: 0, Instability: 0, Special: -
LD50 (median dose) > 6.6×10¹⁰ CFU/kg
NIOSH RNZ2A7H13A
PEL (Permissible) PEL (Permissible Exposure Limit) for Bifidobacterium animalis: Not established
REL (Recommended) 0.083 mg
IDLH (Immediate danger) Not listed
Related compounds
Related compounds Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium longum
Bifidobacterium lactis
Bifidobacterium adolescentis
Related compounds Bifidobacterium lactis
Bifidobacterium longum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium bifidum
Bifidobacterium adolescentis