Material Safety Data Sheet (MSDS): Beta-Cyclodextrin

Identification

Product Name: Beta-Cyclodextrin
Synonyms: β-Cyclodextrin, Cycloheptaamylose, Cyclodextrin B
CAS Number: 7585-39-9
Molecular Formula: C42H70O35
Recommended Use: Pharmaceutical excipient, food additive, encapsulating agent
Manufacturer/Supplier: See packaging or purchase documentation for full distributor information
Emergency Contact: Refer to local poison control center and emergency medical services

Hazard Identification

GHS Classification: Not classified as hazardous according to current global classification criteria
Health Hazards: May cause mild skin or eye irritation after direct contact, inhalation of dust can irritate respiratory tract
Physical Hazards: Not flammable; stable under typical conditions
Target Organs: Eyes, skin, respiratory system
Label Elements: No signal word, hazard pictograms, or precautionary statements required
Routes of Exposure: Inhalation, skin contact, ingestion
Chronic Effects: No known significant effects

Composition / Information on Ingredients

Chemical Identity: Beta-Cyclodextrin
Purity: Typically >98% by HPLC
Impurities: Trace monosaccharides, water
Ingredient Percentages: Beta-Cyclodextrin (100%)
Additives/Stabilizers: None
Allergenic Components: Produced from starch sources; contact supplier regarding allergen control practices

First Aid Measures

Skin Contact: Wash with plenty of soap and water, remove contaminated clothing, seek medical advice if irritation persists
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, seek attention if irritation does not cease
Inhalation: Move person to fresh air, seek medical attention if symptoms persist
Ingestion: Rinse mouth with water, give water to drink if conscious, seek medical advice if large quantity ingested or symptoms develop
Expected Symptoms: Irritation, redness, discomfort

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide for surrounding fire
Unsuitable Extinguishing Media: None known under normal storage
Hazards from Combustion: Possible carbon monoxide and carbon dioxide formation
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Special Procedures: Avoid inhalation of smoke and combustion products

Accidental Release Measures

Personal Precautions: Use suitable protective gear as needed to prevent skin and eye contact
Environmental Precautions: Avoid runoff into sewers, drains or waterways
Containment Methods: Sweep up without creating dust, collect in approved containers for disposal
Cleaning Methods: Clean affected area thoroughly with water
Spillage Response: Ventilate area, remove sources of ignition

Handling and Storage

Handling: Avoid contact with eyes and skin, minimize dust generation, wash hands after handling
Storage: Store in well-ventilated, cool, dry location, keep container tightly closed when not in use
Incompatible Materials: Strong oxidizers may cause degradation
Special Requirements: Protect from moisture and extreme heat

Exposure Controls and Personal Protection

Exposure Limits: No established occupational exposure limit for Beta-Cyclodextrin
Ventilation: Use general or local exhaust ventilation to control airborne dust levels
Eye Protection: Safety goggles recommended for bulk handling
Skin Protection: Protective gloves and long-sleeved garments can limit contact
Respiratory Protection: Use dust mask or respirator if dust formation likely
Hygiene Measures: Implement routine workplace hygiene; no eating, drinking, or smoking during use

Physical and Chemical Properties

Appearance: White crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH (1% solution): 5.0–8.0
Boiling Point: Decomposes before boiling
Melting Point: Decomposes above 270°C
Solubility in Water: 18.5 g/l at 25°C
Solubility in Solvents: Practically insoluble in ethanol, ether, chloroform
Vapor Pressure: Not applicable
Density: 1.46 g/cm³
Partition Coefficient: Not available
Decomposition Temperature: >270°C
Flash Point: Not flammable

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Reactivity: Low under normal handling
Hazardous Polymerization: Will not occur
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide on combustion
Conditions to Avoid: Excessive heat, moisture, strong oxidizers
Incompatible Materials: Strong acids and oxidizing agents

Toxicological Information

Acute Toxicity: LD50 (oral, rat) >12,800 mg/kg (low acute toxicity)
Chronic Toxicity: No significant chronic effects documented in animal studies
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, OSHA
Mutagenicity: Tests indicate negative results for mutagenicity
Reproductive Toxicity: Animal data does not show adverse reproductive effects
Irritation: Mild irritation possible with direct contact
Sensitization: Not reported to cause sensitization in humans
Likely Routes of Exposure: Inhalation, eye and skin contact

Ecological Information

Environmental Mobility: Biodegradable, breaks down in natural environments
Aquatic Toxicity: Low toxicity to aquatic organisms
Terrestrial Toxicity: No signs of significant soil accumulation
Bioaccumulation Potential: Does not bioaccumulate
Persistence and Degradability: Readily biodegradable by microorganisms
Other Adverse Effects: No significant ecosystem impacts expected from normal use

Disposal Considerations

Disposal Methods: Dispose as non-hazardous organic waste in accordance with local, regional, and national regulations
Packaging Disposal: Clean empty containers may be recycled or disposed of as regular waste
Special Precautions: Prevent release in bulk quantities to water systems
Incineration: Permitted in facilities equipped to manage organic materials

Transport Information

UN Number: Not regulated for transport
Transport Hazard Class: Not classified as hazardous for ground, sea, or air transport
Packing Group: No assignment
Shipping Label: No special label required
Special Transport Precautions: Keep packaging intact and secure against rupture during movement
IMDG/IATA/ADR Classification: Not subject to international transport regulations

Regulatory Information

TSCA Status: Listed or approved for use
REACH Registration: Registered under EC regulatory framework
SARA Title III: Not listed as a hazardous substance
California Prop 65: Not listed
DSL/NDSL (Canada): Listed
WHMIS Classification: Non-controlled
Other Regulations: Meets requirements for use in pharmaceuticals and foods as set by recognized global authorities