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Material Safety Data Sheet (MSDS) for Astaxanthin

Identification

Product Name: Astaxanthin
Chemical Formula: C40H52O4
Synonyms: 3,3′-Dihydroxy-β,β-carotene-4,4′-dione
CAS Number: 472-61-7
Recommended Use: Dietary supplement, pigment in feed, antioxidant
Manufacturer: Contact manufacturer or supplier for complete information
Contact Details: Emergency phone number and address should be provided by supplier

Hazard Identification

GHS Classification: Eye irritation (Category 2B), Skin irritation (Category 3); Not classified as hazardous for ingestion at typical exposure levels
Signal Word: Warning
Hazard Statements: May cause mild eye or skin irritation; Dust may cause respiratory discomfort
Precautionary Statements: Avoid breathing dust, wash hands after handling, use in well-ventilated area
Pictograms: Exclamation mark (for irritant effects)

Composition / Information on Ingredients

Chemical Name: Astaxanthin
Concentration: Pure substance or various concentrations in blends
Impurities: Minor byproducts from algae or yeast sources, depending on origin; trace residual solvents below legal limits
Ingredient Disclosure: No other hazardous components above regulatory thresholds

First Aid Measures

Inhalation: Move to fresh air, seek medical attention if symptoms such as coughing or wheezing persist
Eye Contact: Rinse opened eye for several minutes under running water, do not rub eyes, remove contact lenses if present
Skin Contact: Wash skin thoroughly with soap and water; seek medical attention if dermatitis develops
Ingestion: Rinse mouth with water, seek medical advice in case of discomfort or large ingestion
Most Important Symptoms: Eye or skin redness, respiratory tract irritation for sensitive individuals

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: High pressure water streams may spread powder
Hazardous Combustion Products: Carbon dioxide, carbon monoxide, and possibly acrid smoke
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective clothing
Advice for Firefighters: Prevent buildup of dust, as fine dust can form explosive mixtures with air

Accidental Release Measures

Personal Precautions: Avoid generation of dust, provide adequate ventilation, use protective gloves and eyewear
Environmental Precautions: Prevent entry into drains, soil, or watercourses
Methods for Clean Up: Sweep up and place in sealed container for disposal; avoid dry sweeping if dust clouds can form; use HEPA-filtered vacuum for fine particles
Other Information: Report significant spills to regulatory authorities as required

Handling and Storage

Safe Handling: Avoid inhaling dust, wear appropriate PPE, wash thoroughly after handling, avoid eating or drinking where powder is handled
Storage Conditions: Store in tightly closed container in cool, dark, and dry place; protect from sunlight and moisture; keep away from oxidizing agents
Incompatible Materials: Strong acids, bases, oxidizers, and reducing agents
Specific Use Recommendations: For intended industrial or research uses only, keep out of reach of children

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established limits for astaxanthin; treat as nuisance dust (10 mg/m3 total dust, 3 mg/m3 respirable fraction)
Engineering Controls: Use local exhaust ventilation or process enclosure
Eye Protection: Safety goggles or face shield
Skin Protection: Protective gloves, lab coat, or coveralls
Respiratory Protection: NIOSH-approved dust mask if engineering controls are inadequate
Hygiene Measures: Wash thoroughly after handling, remove contaminated clothing, avoid smoking in work area

Physical and Chemical Properties

Appearance: Dark red to reddish-brown powder or crystals
Odor: Odorless or faint, characteristic odor
pH: Insoluble in water, not applicable
Melting Point: 215–216°C
Solubility: Insoluble in water, soluble in oils, lipids, acetone, chloroform
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Negligible at ambient temperature
Flash Point: Not established for solids; product not highly flammable
Partition Coefficient (log Kow): Estimated at 13.77 due to high lipophilicity
Stability: Sensitive to heat, light, and oxygen

Stability and Reactivity

Chemical Stability: Stable in unopened container under recommended storage conditions
Conditions to Avoid: Heat, light, oxygen, moisture; avoid generating airborne dust
Incompatible Materials: Strong oxidizing agents, acids, alkalis
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, possibly irritant organic fumes on thermal decomposition
Possibility of Hazardous Reactions: None under normal processes; vigorous oxidation with strong reagents

Toxicological Information

Acute Toxicity: Oral LD50 for rat >2000 mg/kg; considered low toxicity
Skin Corrosion/Irritation: May cause mild irritation with prolonged exposure
Serious Eye Damage/Irritation: Can lead to temporary irritation, redness
Respiratory Sensitization: Not a known sensitizer at ambient exposure
Germ Cell Mutagenicity: No evidence in available studies
Carcinogenicity: Not listed by IARC, NTP, OSHA
Reproductive Toxicity: No known effects in animal studies at normal dosage
Chronic Effects: Unlikely at typical exposure

Ecological Information

Ecotoxicity: No significant hazard to aquatic life at expected concentrations
Persistence and Degradability: Readily biodegradable as a natural carotenoid
Bioaccumulation: Low potential in the environment; quickly metabolized
Mobility in Soil: Strongly adsorbed, minimal leaching potential
Other Adverse Effects: No known significant environmental impact in food chain

Disposal Considerations

Waste Treatment Methods: Dispose of in accordance with local, regional, and national regulations; do not release into surface waters or sewers
Contaminated Packaging: Empty containers should be cleaned and reused or disposed of following legal requirements
Special Precautions: Handle contaminated material as chemical waste; consult waste management authority for large quantities

Transport Information

UN Number: Not classified as dangerous for transport
UN Proper Shipping Name: Astaxanthin, not regulated
Transport Hazard Class: Not applicable
Packing Group: Not assigned
Environmental Hazards: Not a marine pollutant
Transport in Bulk: Not defined under Annex II of MARPOL 73/78
Special Precautions for User: Protect from direct sunlight, from moisture, and avoid rough handling that may create dust

Regulatory Information

OSHA Status: Not classified as hazardous under US OSHA Hazard Communication Standard
EPA Status: Not listed specifically under TSCA
WHMIS (Canada): Not a controlled product
EU Directives: Not classified as hazardous under Regulation (EC) No 1272/2008
FDA Status: Approved in the US for food, feed, and supplement use as specified
Other Regulations: Maximum permissible levels may be regulated by local or state authorities; always check the latest local rules
Inventory Status: Listed or exempted in major chemical inventories worldwide